Results 1 to 10 of about 29,410 (210)

TNFR2: Role in Cancer Immunology and Immunotherapy

ImmunoTargets and Therapy, 2021
Yang Yang, Md Sahidul Islam, Yuanjia Hu, Xin Chen State Key Laboratory of Quality Research in Chinese Medicine, Institute of Chinese Medical Sciences, University of Macau, Macau, SAR, 999078, People’s Republic of ChinaCorrespondence: Xin ChenState ...
Md Sahidul Islam, Xin Chen
exaly   +6 more sources

Targeting TNFR2 in Cancer: All Roads Lead to Rome [PDF]

Frontiers in Immunology, 2022
TNF receptor 2 (TNFR2) has become one of the best potential immune checkpoints that might be targeted, mainly because of its vital role in tumor microenvironments (TMEs).
Jingchao Bai, Hui Li
exaly   +5 more sources

Novel nanobody-161 binds tumor necrosis factor receptor 2 (TNFR2) to exert an anti-tumor effect but does not block TNFα-binding [PDF]

Frontiers in Immunology
BackgroundTumor necrosis factor receptor 2 (TNFR2) is expressed on regulatory T cells (Tregs) and many cancer cells indicating its potential as a therapeutic target.
Liang Huang, Chao Kong, Chao Kong, Yuhao Hu, Michael Zhang, Shuangqi Li, Wanjing Wang, Hui Guan, Mei Ling Lim, Zhen Zhang, Wenhai Zhang, Hailiang Zheng, Xintian Yan, Xinglu Sun, Pan Lei, Shanshan Dai, Wenrong Wang, Linlin Lu, Junma Zhou, Shilong Fan, Guojun Lang   +20 more
doaj   +2 more sources

TNFR2+ regulatory T cells protect against bacteremic pneumococcal pneumonia by suppressing IL-17A-producing γδ T cells in the lung

Cell Reports, 2023
Summary: Streptococcus pneumoniae is a pathogen of global morbidity and mortality. Pneumococcal pneumonia can lead to systemic infections associated with high rates of mortality.
Neil French, Aras Kadioglu
exaly   +3 more sources

A novel TNFR2 agonist peptide for the expansion of CD4+Foxp3+ regulatory T cells [PDF]

Frontiers in Immunology
CD4+Foxp3+ regulatory T cells (Tregs) are essential for maintaining immune tolerance, and selective expansion of Tregs via TNFR2 signaling represents a promising therapeutic approach for autoimmune and inflammatory diseases.
Ping Liao, Zhonghao Chen, Yang Gao, Yang Yang, Yibo Chen, Jiamin Chen, Yiru Wang, Chon-Kit Chou, Shaoyi Zhang, Xin Chen, Xin Chen, Xin Chen   +11 more
doaj   +2 more sources

Stress-Programmed Immune Niches Fuel TNFR2+ Treg Activation and Drive Neoadjuvant Chemotherapy Resistance in Breast Cancer. [PDF]

Adv Sci (Weinh)
Single‐cell sequencing reveals stress‐programmed immune states driving TNFα–TNFR2–mediated Treg activation and therapy resistance in breast cancer, while targeting this axis restores antitumor immunity. ABSTRACT The tumor microenvironment (TME) harbors diverse immune cell states that shape therapeutic outcomes in breast cancer.
Shao Z, Wang X, Zhu H, Yao L, Zhang Q, Zhai Z, Lv X, Xia X, Zhang Y, Lu X, Quan X, Yang J, Li X, Dong J, Shao ZM, Wang R, Xiu B, Wu J, Chen S.   +18 more
europepmc   +2 more sources

TNFR2 signaling shapes the sex-specific remyelinating properties of microglia after experimental stroke [PDF]

Neurotherapeutics
Microglial tumor necrosis factor receptor 2 (TNFR2) has emerged as a critical modulator of neuroinflammation and repair following ischemic stroke. Here, we investigated the sex-specific role of TNFR2 in regulating microglial responses during the acute ...
Stefano Raffaele, Francesca Carolina Mannella, Estrid Thougaard, Pernille Vinther Nielsen, Morten Blickfeldt-Eckhardt, Eva Tolosa, Justine Münsterberg, Tim Magnus, Jens D. Mikkelsen, Mathias Gelderblom, Helle Hvilsted Nielsen, Bettina Hjelm Clausen, Roberta Brambilla, Marta Fumagalli, Kate Lykke Lambertsen   +14 more
doaj   +2 more sources

TNFR2 Signaling Enhances ILC2 Survival, Function, and Induction of Airway Hyperreactivity

Cell Reports, 2019
Summary: Group 2 innate lymphoid cells (ILC2s) can initiate pathologic inflammation in allergic asthma by secreting copious amounts of type 2 cytokines, promoting lung eosinophilia and airway hyperreactivity (AHR), a cardinal feature of asthma.
Jennifer L Aron, Doumet Georges Helou, Omid Akbari   +2 more
exaly   +3 more sources

Mapping the TNFR2-targeting antibody patent landscape: Insights from macro trends to structural signatures [PDF]

Human Vaccines & Immunotherapeutics
Pharmacological modulation of TNFR2 function has emerged as an effective strategy for modulating immune responses in cancer and inflammatory diseases. Both academic and industrial efforts have pursued therapeutic approaches targeting TNFR2, leading to a ...
Shiyun Chen, Yibo Chen, Yexuan Zhang, Gengyuan Yao, Hong Cai, Xin Chen, Yuanjia Hu   +6 more
doaj   +2 more sources

TNFα Receptor 1 and Not Receptor 2 Affect Annulus Fibrosus and Nucleus Pulposus Response to Cytokine Challenge in a Rat Model [PDF]

JOR Spine
Background Painful intervertebral disc (IVD) degeneration (IVDD) involves chronic inflammation. Developing translational immunomodulatory strategies for IVDD is a priority with tumor necrosis factor alpha (TNFα) signaling an important target.
Timothy D. Jacobsen, S. Olga Yiantsos, Jennifer Gansau, James Meyers, Damien Laudier, James C. Iatridis   +5 more
doaj   +2 more sources