TNFα induces Ca2+ influx to accelerate extrinsic apoptosis in hepatocellular carcinoma cells [PDF]
, 2018 BACKGROUND: Tumor necrosis factor-α has been proven an effective anticancer agent in preclinical studies. However, the translation of TNFα from research to clinic has been blocked by significant systemic toxicity and limited efficacy at maximal tolerated
Ji, Xiaoying +10 more
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Solution of the Structure of the TNF-TNFR2 Complex [PDF]
Science Signaling, 2010 Structural differences in the binding of tumor necrosis factor to its two receptors may aid in the development of receptor-specific therapeutics.
Yohei, Mukai +7 more
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Distinct contributions of TNF receptor 1 and 2 to TNF-induced glomerular inflammation in mice. [PDF]
PLoS ONE, 2013 TNF is an important mediator of glomerulonephritis. The two TNF-receptors TNFR1 and TNFR2 contribute differently to glomerular inflammation in vivo, but specific mechanisms of TNFR-mediated inflammatory responses in glomeruli are unknown. We investigated
Anela Taubitz +4 more
doaj +1 more source
Sh3bp2 Gain-Of-Function Mutation Ameliorates Lupus Phenotypes in B6.MRL-Faslpr Mice [PDF]
, 2019 SH3 domain-binding protein 2 (SH3BP2) is an adaptor protein that is predominantly expressed in immune cells, and it regulates intracellular signaling. We had previously reported that a gain-of-function mutation in SH3BP2 exacerbates inflammation and bone
Iseki, Masanori +9 more
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TNFR2 pathways are fully active in cancer regulatory T cells [PDF]
Bioscience, Biotechnology, and Biochemistry, 2022 ABSTRACTTumor necrosis factor receptor 2 (TNFR2), a membrane-bound tumor necrosis factor receptor expressed by regulatory T cells (Tregs), participates in Treg proliferation. Although a specific TNFR2 pathway has been reported, the signaling mechanism has not been completely elucidated.
Yuumi Okuzono, Yo Muraki, Shuji Sato
openaire +2 more sources
Annales Academiae Medicae SilesiensisIntroduction: Despite their promising anticancer properties, betulin derivatives may have serious side effects, including nephrotoxicity. Tumor necrosis factor (TNF) and its receptors may play crucial roles in renal cells’ reaction to these compounds ...
Joanna Gola +6 more
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Thoracic Cancer, 2019 Background Tumor necrosis factor receptor 2 (TNFR2) promotes tumor cell proliferation, activates immunosuppressive cells, and supports immune escape. However, its role in non‐small cell lung cancer (NSCLC) has not been reported. Methods Quantitative real‐
Yan Wen Zhang +7 more
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Chronic Inflammation Increases the Sensitivity of Mouse Treg for TNFR2 Costimulation
Frontiers in Immunology, 2017 TNF receptor type 2 (TNFR2) has gained attention as a costimulatory receptor for T cells and as critical factor for the development of regulatory T cells (Treg) and myeloid suppressor cells.
Tobias Schmid +12 more
doaj +1 more source
Relationship between serum tumor necrosis factor receptor-2 concentration and periodontal destruction in patients with type 2 diabetes: Cross-sectional study [PDF]
Srpski Arhiv za Celokupno Lekarstvo, 2016 Introduction. The role of tumor necrosis factor-α (TNFα) is well documented in pathogenesis of chronic periodontitis (CP) and type 2 diabetes (T2D).
Matić-Petrović Sanja +6 more
doaj +1 more source
Cellular and molecular basis of TNFa, IL-1ß and LPS mediated signaling in rat dorsal root ganglion [PDF]
, 2004 The proinflammatory cytokines TNFa and IL-1ß as well as bacterial lipopolysaccharide (LPS) are known to affect primary afferent functions related to pain and neurogenic inflammation.
Li, Yanzhang +1 more
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