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Role of Tumor Necrosis Factor in Tuberculosis [PDF]
BiomoleculesTumor necrosis factor (TNF) is a key immunoregulatory cytokine with a dual role in the host response to Mycobacterium tuberculosis. While essential for granuloma formation, macrophage activation, and containment of latent infection, TNF can also ...
Fedor D. Kireev +3 more
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Comparative Analysis of TNF-alpha, TNF-R1, and TNF-R2 in Patients with Low-impact Fractures Due to Osteoporosis [PDF]
Revista Brasileira de Ortopedia, 2023 Objective To analyze the serum levels of TNF-alpha and its TNF-R1 and TNF-R2 receptors in the blood of patients with low-impact fractures due to osteoporosis, comparing between genders and with healthy patients. Methods The present study was conducted
Abel Oliveira Marques Teixeira +5 more
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Cancer Letters, 2013 Tumor necrosis factor (TNF) is a critical cytokine, which contributes to both physiological and pathological processes. This mini-review will briefly touch the history of TNF discovery, its family members and its biological and pathological functions. Then, it will focus on new findings on the molecular mechanisms of how TNF triggers activation of the ...
F. Atzeni, P. Sarzi-Puttini
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Implication of Tumor Necrosis Factor - Alpha in Preeclampsia [PDF]
Applied Medical Informatics, 2008 Introduction: Preeclampsia is an exacerbation of a generalized inflammatory response, physiologically present in the third trimester of pregnancy.Aim: The aim of the study consists in the evaluation of proinflammatory cytokine TNF-α in the context of ...
Dan MIHU +4 more
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Tumor necrosis factor signaling [PDF]
Cell Death & Differentiation, 2003 A single mouse click on the topic tumor necrosis factor (TNF) in PubMed reveals about 50,000 articles providing one or the other information about this pleiotropic cytokine or its relatives. This demonstrates the enormous scientific and clinical interest in elucidating the biology of a molecule (or rather a large family of molecules), which began now ...
H, Wajant, K, Pfizenmaier, P, Scheurich
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Tumor necrosis factor, tumor necrosis factor inhibition, and cancer risk [PDF]
Current Medical Research and Opinion, 2015 Tumor necrosis factor (TNF) is a highly pleiotropic cytokine with multiple activities other than its originally discovered role of tumor necrosis in rodents. TNF is now understood to play a contextual role in driving either tumor elimination or promotion.
Hervé, Lebrec +5 more
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Tumor Necrosis Factor Alpha Signaling and Organogenesis
Frontiers in Cell and Developmental Biology, 2021 Tumor necrosis factor alpha (TNF-α) plays important roles in processes such as immunomodulation, fever, inflammatory response, inhibition of tumor formation, and inhibition of viral replication.
Kai You +4 more
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PLoS Biology, 2020 Tumor necrosis factor-alpha (TNF-α) plays an important pathogenic role in cardiac hypertrophy and heart failure (HF); however, anti-TNF is paradoxically negative in clinical trials and even worsens HF, indicating a possible protective role of TNF-α in HF.
Kun Miao +9 more
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Journal of the American Academy of Dermatology, 1991 Tumor necrosis factor is important in systemic and cutaneous defense, homeostasis, and many disease states. The numerous and diverse effects of tumor necrosis factor are best understood when considered as concentration-dependent, with normal homeostasis progressing to defense followed by toxic effects.
P E, Wakefield +3 more
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Scientific American, 1988 A century ago it was noted that a bacterial infection sometimes causes the regression of cancer. In 1975 the author found an explanation: the infection stimulates the secretion of tumor necrosis factor (TNF), which has anticancer activity. Now TNF, an important regulator of inflammation and immunity, is in clinical trials as an anticancer drug.
H F, Oettgen, L J, Old
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