Results 11 to 20 of about 725,440 (353)

Small tumor necrosis factor receptor biologics inhibit the tumor necrosis factor-p38 signalling axis and inflammation

Nature Communications, 2018
Anti-TNF therapy has improved the treatment of inflammatory disease but can predispose to infection and malignancy. Here the authors show an anti-TNF biologic peptide that functionally and selectively targets the TNF-p38 pathway in multiple models of ...
Violet R. Mukaro, Alex Quach, Michelle E. Gahan, Bernadette Boog, Zhi H. Huang, Xiuhui Gao, Carol Haddad, Suresh Mahalingam, Charles S. Hii, Antonio Ferrante   +9 more
doaj   +2 more sources

Tumor necrosis factor-alpha inhibitor treatment for sarcoidosis

Therapeutics and Clinical Risk Management, 2008
José Luis Callejas-Rubio, Lourdes López-Pérez, Norberto Ortego-CentenoUnit of Autoimmune Systemic Diseases, Hospital Clinico San Cecilio, Granada, SpainAbstract: Sarcoidosis is a chronic multisystem disease of unknown ...
José Luis Callejas-Rubio, Lourdes López-Pérez, Norberto Ortego-Centeno   +2 more
doaj   +1 more source

Comparison of drug survival rates for tumor necrosis factor antagonists in rheumatoid arthritis

Patient Preference and Adherence, 2013
Virginia Martínez-Santana,1 E González-Sarmiento,2 MA Calleja-Hernández,3 T Sánchez-Sánchez1 1Pharmacy Department, Hospital Clínico Universitario de Valladolid, Valladolid, Spain; 2Internal Medicine Department ...
Martínez-Santana V, González-Sarmiento E, Calleja-Hernández MA, Sánchez-Sánchez T   +3 more
doaj   +3 more sources

Non-tumor necrosis factor-based biologic therapies for rheumatoid arthritis: present, future, and insights into pathogenesis

Biologics: Targets & Therapy, 2013
Filipe Seguro Paula,1 José Delgado Alves1,2 1Immunomediated Systemic Diseases Unit, Department of Medicine 4, Fernando Fonseca Hospital, Amadora, 2Center for the Study of Chronic Diseases, Department of Pharmacology, Faculty of Medical Sciences ...
Paula FS, Delgado Alves J
doaj   +1 more source

There exists only one tumor necrosis factor

Медицинская иммунология, 2021
Tumor necrosis factor (TNF) is an important proinflammatory and immunoregulatory cytokine with several unique protective and homeostatic functions. Since TNF is a mediator of several pathologies and is a part of “cytokine storm”, its significance for ...
S. A. Nedospasov
doaj   +1 more source

Downregulation of Tumor Necrosis Factor Expression in the Human Mono-Mac-6 Cell Line [PDF]

, 1989
Mono-Mac-6 cells, but not U937 cells, can be Induced to rapidly express tumor necrosis factor (TNF) mRNA and protein when triggered with Ilpopolysaccharlde (LPS) at 1 pg/mI. Preincubatlon of the cells for 3 d with low amounts of LPS (10 ng/mI) results In
Thiel, Corinna, Haas, Jürgen G., Ziegler-Heitbrock, H. W. Löms, Blömer, Kathi, Weiss, Elisabeth H., Riethmüller, Gert   +5 more
core   +1 more source

Anti tumor necrosis factor induced focal myositis

Proceedings of Singapore Healthcare, 2022
Tumour necrosis factor inhibitors (TNFis) can trigger autoantibody formation and, in a small proportion of patients, result in symptomatic autoimmune diseases, including polymyositis and dermatomyositis. Focal myositis presents with localized muscle pain
Adrian Mark Masnammany, Wendy Lau, Peter Kee Kee Wong, Nicholas Manolios   +3 more
doaj   +1 more source

T lymphocytes from patients with primary biliary cirrhosis produce reduced amounts of lymphotoxin, tumor necrosis factor and interferon-gamma upon mitogen stimulation [PDF]

, 1992
Primary biliary cirrhosis (PBC) is considered an autoimmune disease characterized by destruction of small intrahepatic bile ducts by lymphocytes. Altered functions of these lymphocytes might reflect an abnormal immune response leading to tissue damage ...
Eisenburg, Josef, Spengler, Ulrich, Hoffmann, Robert M., Paumgartner, Gustav, Jung, Maria C., Messer, Gerald, Möller, Achim, Weiss, Elisabeth H., Zachoval, Reinhard, Riethmüller, Gert   +9 more
core   +1 more source

Tumor Necrosis Factor and Tuberculosis [PDF]

Journal of Investigative Dermatology Symposium Proceedings, 2007
Tumor necrosis factor (TNF) plays a major role in the initial and long-term control of tuberculosis. The mechanisms by which this cytokine contributes to the control of Mycobacterium tuberculosis infection are numerous and therefore difficult to dissect. TNF is important in macrophage activation as well as cell recruitment to the site of infection.
Lin, Philana Ling, Plessner, Hillarie L., Voitenok, Nikolai N., Flynn, JoAnne L.   +3 more
openaire   +2 more sources

Molecular cloning, expression analysis and assignment of the porcine tumor necrosis factor superfamily member 10 gene (TNFSF10) to SSC13q34 -> q36 by fluorescence in situ hybridization and radiation hybrid mapping [PDF]

, 2005
We have cloned the complete coding region of the porcine TNFSF10 gene. The porcine TNFSF10 cDNA has an ORF of 870 nucleotides and shares 85 % identity with human TNFSF10, and 75% and 72% identity with rat and mouse Tnfsf10 coding sequences, respectively.
Kemter, E., Kemter, E, Leeb, T., Kuiper, H., Klose, R., Boelhauve, M., Kuiper, H, Philipp, U., Philipp, U, Wolf, E, Distl, O., Wolf, E., Klose, R, Leeb, Tosso, Distl, O, Boelhauve, M   +15 more
core   +1 more source