Results 1 to 10 of about 548,351 (161)

Tumor Necrosis Factor Alpha Signaling and Organogenesis

Frontiers in Cell and Developmental Biology, 2021
Tumor necrosis factor alpha (TNF-α) plays important roles in processes such as immunomodulation, fever, inflammatory response, inhibition of tumor formation, and inhibition of viral replication.
Kai You, Hui Gu, Zhengwei Yuan, Xuewen Xu, Xuewen Xu   +4 more
doaj   +2 more sources

Thalidomide selectively inhibits tumor necrosis factor alpha production by stimulated human monocytes.

Journal of Experimental Medicine, 1991
Thalidomide selectively inhibits the production of human monocyte tumor necrosis factor alpha (TNF-alpha) when these cells are triggered with lipopolysaccharide and other agonists in culture. 40% inhibition occurs at the clinically achievable dose of the
Elizabeth P Sampaio, Euzenir Nunes Sarno, Z A Cohn   +2 more
exaly   +2 more sources

Tumor necrosis factor-alpha-mediated inflammatory bone loss: Pathogenic mechanisms and therapeutic potential of its inhibitors [PDF]

Tzu Chi Medical Journal
Bone remodeling preserves skeletal integrity through the balanced actions of bone-resorbing osteoclasts and bone-forming osteoblasts, regulated by mechanical, endocrine, and immune signals.
Wen-Ying Lin, Yu-Jen Pan, Kuang-Ting Yeh, Kuei-Ying Su, Kameshwara Kumar Dharini, Ing-Ho Chen, Wen-Tien Wu, Ming-Der Lin, Cheng-Huan Peng   +8 more
doaj   +2 more sources

Tumor Necrosis Factor Alpha: A Link between Neuroinflammation and Excitotoxicity

Mediators of Inflammation, 2014
Tumor necrosis factor alpha (TNF-α) is a proinflammatory cytokine that exerts both homeostatic and pathophysiological roles in the central nervous system.
Gabriel Olmos, Jerònia Lladó
doaj   +2 more sources

Human keratinocytes are a source for tumor necrosis factor alpha: evidence for synthesis and release upon stimulation with endotoxin or ultraviolet light.

Journal of Experimental Medicine, 1990
Tumor necrosis factor alpha (TNF-alpha), in addition to being cytotoxic for certain tumor cells, has turned out as a multifunctional cytokine that is involved in the regulation of immunity and inflammation.
A Kock, Thomas Schwarz, R Kirnbauer
exaly   +2 more sources

Comparative Analysis of TNF-alpha, TNF-R1, and TNF-R2 in Patients with Low-impact Fractures Due to Osteoporosis [PDF]

Revista Brasileira de Ortopedia, 2023
Objective To analyze the serum levels of TNF-alpha and its TNF-R1 and TNF-R2 receptors in the blood of patients with low-impact fractures due to osteoporosis, comparing between genders and with healthy patients. Methods The present study was conducted
Abel Oliveira Marques Teixeira, Virmondes Rodrigues-Júnior, Bárbara Rocha Rodrigues, Danila Malheiros Souza, Leonardo Franco Pinheiro Gaia, Denise Bertulucci Rocha Rodrigues   +5 more
doaj   +1 more source

The Role of Tumor Necrosis Factor Alpha (TNF-α) in Autoimmune Disease and Current TNF-α Inhibitors in Therapeutics

International Journal of Molecular Sciences, 2021
Tumor necrosis factor alpha (TNF-α) was initially recognized as a factor that causes the necrosis of tumors, but it has been recently identified to have additional important functions as a pathological component of autoimmune diseases. TNF-α binds to two
Dan-in Jang, A-Hyeon Lee, Hye-Yoon Shin, Hyo-Ryeong Song, Jong-Hwi Park, T. Kang, Sang-Ryong Lee, Seung-Hoon Yang   +7 more
semanticscholar   +1 more source

Adverse events of tumor necrosis factor alpha inhibitors for the treatment of ankylosing spondylitis: A meta-analysis of randomized, placebo-controlled trials

Frontiers in Pharmacology, 2023
Objective: Tumor necrosis factor alpha inhibitors (TNFi) have shown substantial efficacy in alleviating and treating ankylosing spondylitis (AS). However, the heightened interest is accompanied by concerns over adverse events.
Haihuan Feng, Haihuan Feng, Ying Zhao, Weihong Kuang, Yanping Dai, Xiaobo Cen, Feng Qin, Feng Qin   +7 more
doaj   +1 more source

Harnessing Tumor Necrosis Factor Alpha to Achieve Effective Cancer Immunotherapy

Cancers, 2021
Simple Summary Inflammation has been acknowledged as one of the causes of increased cancer risk. Among the pro-inflammatory mediators, tumor necrosis factor alpha (TNFα) has been identified as an important player in cancer progression and metastasis.
M. Mercogliano, Sofía Bruni, F. Mauro, P. Elizalde, R. Schillaci   +4 more
semanticscholar   +1 more source

Phytochemicals as inhibitors of tumor necrosis factor alpha and neuroinflammatory responses in neurodegenerative diseases

Neural Regeneration Research, 2022
Inflammatory processes and proinflammatory cytokines have a key role in the cellular processes of neurodegenerative diseases and are linked to the pathogenesis of functional and mental health disorders.
Fatemeh Zahedipour, Seyede Atefe Hosseini, Neil C Henney, George E Barreto, Amirhossein Sahebkar   +4 more
doaj   +1 more source