Results 21 to 30 of about 6,142,230 (303)

Epigenetic Regulation of Tumor Necrosis Factor Alpha [PDF]

Molecular and Cellular Biology, 2007
Tumor necrosis factor alpha (TNF-alpha) is a potent cytokine which regulates inflammation via the induction of adhesion molecules and chemokine expression. Its expression is known to be regulated in a complex manner with transcription, message turnover, message splicing, translation, and protein cleavage from the cell surface all being independently ...
K E, Sullivan, A B M, Reddy, K, Dietzmann, A R, Suriano, V P, Kocieda, M, Stewart, M, Bhatia   +6 more
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Eicosanoids and tumor necrosis factor-alpha in the kidney [PDF]

Prostaglandins & Other Lipid Mediators, 2012
The thick ascending limb of Henle's loop (TAL) is capable of metabolizing arachidonic acid (AA) by cytochrome P450 (CYP450) and cyclooxygenase (COX) pathways and has been identified as a nephron segment that contributes to salt-sensitive hypertension. Previous studies demonstrated a prominent role for CYP450-dependent metabolism of AA to products that ...
Ferreri, Nicholas R., Hao, Shoujin, Pedraza, Paulina L., Escalante, Bruno, Vio, Carlos P.   +4 more
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Locally up-regulated lymphotoxin a, not systemic tumor necrosis factor a, is the principle mediator of murine cerebral malaria [PDF]

, 2002
Cerebral malaria (CM) causes death in children and nonimmune adults. TNF-{alpha} has been thought to play a key role in the development of CM. In contrast, the role of the related cyto-kine lymphotoxin {alpha} (LT{alpha}) in CM has been overlooked.
Sanjeet Sawhney, Mynott, T.L., Kaye, PM, De Souza, J Brian, Bickle, Quentin D, Kaye, P.M., Engwerda, C.R., Sawhney, Sanjeet, Engwerda, CR, Tracey L. Mynott, Paul M. Kaye, Christian R. Engwerda, Bickle, Q.D., Sawhney, S, Bickle, QD, Mynott, Tracey L, De Souza, JB, Mynott, TL, Engwerda, Christian R, Sawhney, S., J. Brian De Souza, Quentin D. Bickle, Kaye, Paul M, De Souza, J.B.   +23 more
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Alopecia secondary to anti-tumor necrosis factor-alpha therapy [PDF]

Anais Brasileiros de Dermatologia, 2015
Biologic drugs represent a substantial progress in the treatment of chronic inflammatory immunologic diseases. However, its crescent use has revealed seldom reported or unknown adverse reactions, mainly associated with anti-tumor necrosis factor (anti ...
Lara Beatriz Prata Ribeiro, Juliana Carlos Gonçalves Rego, Bruna Duque Estrada, Paula Raso Bastos, Juan Manuel Piñeiro Maceira, Celso Tavares Sodré   +5 more
doaj   +1 more source

Identification of a tumor necrosis factor-responsive element in the tumor necrosis factor alpha gene

Journal of Biological Chemistry, 1991
The regulation by tumor necrosis factor alpha (TNF) of its own promoter has been investigated by transient transfection and nuclear protein binding assays. In human K652 erythroleukemia cells TNF produced an 8-10-fold activation of the human TNF promoter linked to the chloramphenicol acetyltransferase gene.
D C, Leitman, R C, Ribeiro, E R, Mackow, J D, Baxter, B L, West   +4 more
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Tumor Necrosis Factor Alpha-Mediated Asthma? [PDF]

International Archives of Allergy and Immunology, 2012
Thus the pathophysiology of allergic asthma is traditionally explained by mast celland/or Th2 cell-mediated airway inflammation, which is a manifestation of the acquired immune response. On the other hand, recent studies have identified various other important molecules associated with phenotypes of asthma, including tumor necrosis factor (TNF)[2, 3] ,
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Development of low blood glucose readings in nine non-diabetic patients treated with tumor necrosis factor-alpha inhibitors: a case series

Journal of Medical Case Reports, 2012
Introduction Treatment with various biological agents in disease states such as rheumatoid arthritis has been associated with multiple side effects. Whereas many of these are frequently reported in the literature, hypoglycemia, a possible side effect of ...
Czajkowska Jadwiga B, Shutty Brandon, Zito Susan   +2 more
doaj   +1 more source

Evaluation of Tumor Necrosis Factor Alpha Polymorphism Frequencies in Endometriosis [PDF]

International Journal of Fertility and Sterility, 2015
Background The pro-inflammatory cytokine, tumor necrosis factor-alpha (TNF-α), is a pathogenic element for a number of disorders. Previous studies have reported that the -1031 T/C and -238 G/A polymorphisms in the promoter region of the TNF-α gene are ...
Roshanak Abutorabi, Azar Baradaran, Fatemeh Sadat Mostafavi, Yasaman Zarrin, Farahnaz Mardanian   +4 more
doaj   +1 more source

Tumor Necrosis Factor-α Contributes to Ischemia- and Reperfusion-Induced Endothelial Activation in Isolated Hearts [PDF]

, 1999
During myocardial reperfusion, polymorphonuclear neutrophil (PMN) adhesion involving the intercellular adhesion molecule-1 (ICAM-1) may lead to aggravation and prolongation of reperfusion injury.
Kelly, Ralph A., Stefan Zahler, Habazettl, Helmut, Goedecke, Axel, Becker, Bernhard F., Dieter A. Wolf, Christian Kupatt, Helmut Habazettl, Boekstegers, Peter, Bernhard F. Becker, Kupatt, Christian, Peter Boekstegers, Zahler, Stefan, Wolf, Dieter A., Ralph A. Kelly, Axel Goedecke   +15 more
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УГНЕТЕНИЕ ПРОТИВООПУХОЛЕВОЙ ЦИТОТОКСИЧЕСКОЙ АКТИВНОСТИ ДЕНДРИТНЫХ КЛЕТОК У БОЛЬНЫХ ЗЛОКАЧЕСТВЕННЫМИ ЛИМФОМАМИ, ОБУСЛОВЛЕННОЕ ИЗМЕНЕННОЙ ЭКСПРЕССИЕЙ ФАКТОРА НЕКРОЗА ОПУХОЛИ АЛЬФА [PDF]

, 2016
Recent research revealed dendritic cells (DCs) to have direct antitumor cytotoxic activity and to inhibit the growth and proliferation of tumor cells in vitro. The aim of the present study was to investigate the association between the cytotoxic activity
I. V. Kryuchkova, G. Yu. Ushakova, V. V. Sergeevicheva, И. В. Крючкова, М. А. Тихонова, D. S. Batorova, Д. С. Баторова, С. А. Сизикова, S. A. Sizikova, Т. В. Тыринова, Г. Ю. Ушакова, E. R. Chernykh, A. A. Ostanin, В. В. Сергеевичева, А. А. Останин, T. V. Tyrinova, M. A. Tikhonova, O. Yu. Leplina, Е. Р. Черных, О. Ю. Леплина   +19 more
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