Results 51 to 60 of about 29,410 (210)

A new venue of TNF targeting [PDF]

, 2018
The first Food and Drug Administration-(FDA)-approved drugs were small, chemically-manufactured and highly active molecules with possible off-target effects, followed by protein-based medicines such as antibodies.
Libert, Claude, Steeland, Sophie, Vandenbroucke, Roosmarijn   +2 more
core   +1 more source

GRN Activates TNFR2 to Promote Macrophage M2 Polarization Aggravating Mycobacterium Tuberculosis Infection

Frontiers in Bioscience-Landmark
Background: The polarization of macrophages plays a critical role in the immune response to infectious diseases, with M2 polarization shown to be particularly important in various pathological processes.
Bingling Zhang, Lan Xiang, Jun Chen, Jun Zhang, Renliu Dong, Guolun Mo, Feng Wu   +6 more
doaj   +1 more source

TNFR2 deficiency impairs the growth of mouse colon cancer

International Journal of Biological Sciences, 2023
Objective: Tumor necrosis factor (TNF) receptor type II (TNFR2) is expressed by a wide spectrum of tumor cells including colon cancer, non-Hodgkin lymphoma, myeloma, renal carcinoma and ovarian cancer, and its exact role remains to be fully understood. In this study, we examined the effect of genetic ablation of TNFR2 on in vitro and in vivo growth of ...
Li, Ping, Yang, Yang, Yang, Xinyu, Wang, Yifei, Chou, Chon-Kit, Jiang, Mengmeng, Zheng, Jingbin, Chen, Fengyang, Chen, Xin   +8 more
openaire   +2 more sources

Targeting Lactate and Lactylation in Cancer Metabolism and Immunotherapy

Advanced Science, EarlyView.
Lactate, once deemed a metabolic waste, emerges as a central regulator of cancer progression. This review elucidates how lactate and its epigenetic derivative, protein lactylation, orchestrate tumor metabolism, immune suppression, and therapeutic resistance.
Jiajing Gong, Yuhang Xie, Zhijie Weng, Yongzhi Wu, Longjiang Li, Bo Li   +5 more
wiley   +1 more source

Молекулярно-генетические характеристики пациенток с гиперплазией и полипами эндометрия [PDF]

, 2018
Гиперпластические процессы эндометрия (ГПЭ) являются одними из наиболее частых гинекологических заболеваний, приводят к потере репродуктивной функции и снижению качества жизни женщин, являются основой для формирования злокачественных опухолей эндометрия.
Демакова, Н. А.
core   +2 more sources

RENAL‐CHIP: Rejection Evaluation via Non‐Invasive Analysis of Circulating Podocytes With Herringbone‐Chip Isolation Platform

Advanced Science, EarlyView.
RENAL‐CHIP converts 1 mL of peripheral blood into a biopsy‐equivalent readout of renal‐allograft fate. By magnetic capture and release of donor‐derived circulating podocytes through a herringbone microfluidic chip, 84% capture, 96% release and single‐cell RNA evidence of rejection‐specific immunity are achieved.
Juan Song, Yilong Liu, Zeyuan Zheng, Ming Zhu, Yuning Zou, Pei Liu, Yue Zheng, Xiyuan Yu, Jianzhong Zheng, Chen Shao, Huimin Zhang, Chaoyong Yang   +11 more
wiley   +1 more source

Novel strategies to mimic transmembrane tumor necrosis factor-dependent activation of tumor necrosis factor receptor 2

Scientific Reports, 2017
Tumor necrosis factor receptor 2 (TNFR2) is known to mediate immune suppression and tissue regeneration. Interestingly, the transmembrane form of tumor necrosis factor (tmTNF) is necessary to robustly activate TNFR2. To characterize the stoichiometry and
Roman Fischer, Jessica Marsal, Cristiano Guttà, Stephan A. Eisler, Nathalie Peters, John R. Bethea, Klaus Pfizenmaier, Roland E. Kontermann   +7 more
doaj   +1 more source

T Cell Exhaustion in Cancer Immunotherapy: Heterogeneity, Mechanisms, and Therapeutic Opportunities

Advanced Science, EarlyView.
T cell exhaustion limits immunotherapy efficacy. This article delineates its progression from stem‐like to terminally exhausted states, governed by persistent antigen, transcription factors, epigenetics, and metabolism. It maps the exhaustion landscape in the TME and proposes integrated reversal strategies, providing a translational roadmap to overcome
Yang Yu, Xiaoyu Yao, Qingyang Wang, Mengrui Yang, Runze Li, Jiangjiang Qin, Jing Zhuang, Changgang Sun   +7 more
wiley   +1 more source

Stimulation of microglial metabotropic glutamate receptor mGlu2 triggers tumor necrosis factor alpha-induced neurotoxicity in concert with microglial-derived fas ligand [PDF]

, 2005
Activated microglia may be detrimental to neuronal survival in a number of neurodegenerative diseases. Thus, strategies that reduce microglial neurotoxicity may have therapeutic benefit.
Jones, F, Kubota, ESFCS, Pocock, JM, Taylor, DL   +3 more
core  

TNFR2-NIK-cAbl axis for neurodegeneration

, 2023
According to the current view, tumor necrosis factor (TNF) receptor 2 (TNFR2) provides neuroprotection and regeneration by activating both canonical and noncanonical NF-κB pathways when activated by paracrine membrane-bound TNF (mTNF). A careful analysis of the literature reveals, however, that mTNF-mediated TNFR2 stimulation only stimulates canonical ...
openaire   +1 more source