TNF RECEPTOR 2 AND DISEASE: Autoimmunity and Regenerative Medicine [PDF]
Frontiers in Immunology, 2013 The regulatory cytokine tumor necrosis factor (TNF) exerts its effects through two receptors: TNFR1 and TNFR2. Defects in TNFR2 signaling are evident in a variety of autoimmune diseases.
Denise Louise Faustman +2 more
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Role of TNF–TNF Receptor 2 Signal in Regulatory T Cells and Its Therapeutic Implications [PDF]
Frontiers in Immunology, 2018 Tumor necrosis factor α (TNFα) is a pleiotropic cytokine which signals through TNF receptor 1 (TNFR1) and TNF receptor 2 (TNFR2). Emerging evidence has demonstrated that TNFR1 is ubiquitously expressed on almost all cells, while TNFR2 exhibits a limited ...
Sujuan Yang +4 more
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TNF Receptor 2 Makes Tumor Necrosis Factor a Friend of Tumors [PDF]
Frontiers in Immunology, 2018 Tumor necrosis factor (TNF) is widely accepted as a tumor-suppressive cytokine via its ubiquitous receptor TNF receptor 1 (TNFR1). The other receptor, TNFR2, is not only expressed on some tumor cells but also on suppressive immune cells, including ...
Yuqiao Sheng, Feng Li, Zhihai Qin
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Membrane lymphotoxin-α2β is a novel tumor necrosis factor (TNF) receptor 2 (TNFR2) agonist [PDF]
Cell Death and Disease, 2021 In the early 1990s, it has been described that LTα and LTβ form LTα2β and LTαβ2 heterotrimers, which bind to TNFR1 and LTβR, respectively. Afterwards, the LTαβ2–LTβR system has been intensively studied while the LTα2β–TNFR1 interaction has been ignored ...
Kirstin Kucka +5 more
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Activation of TNF Receptor 2 Improves Synaptic Plasticity and Enhances Amyloid-β Clearance in an Alzheimer's Disease Mouse Model with Humanized TNF Receptor 2. [PDF]
J Alzheimers Dis, 2023 Background: Tumor necrosis factor-alpha (TNF-α) is a master cytokine involved in a variety of inflammatory and neurological diseases, including Alzheimer’s disease (AD). Therapies that block TNF-α proved ineffective as therapeutic for neurodegenerative diseases, which might be explained by the opposing functions of the two receptors of TNF (TNFRs ...
Ortí-Casañ N +11 more
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Deletion of the non-adjacent genes UL148 and UL148D impairs human cytomegalovirus-mediated TNF receptor 2 surface upregulation [PDF]
Frontiers in Immunology, 2023 Human cytomegalovirus (HCMV) is a prototypical β-herpesvirus which frequently causes morbidity and mortality in individuals with immature, suppressed, or senescent immunity.
Vu Thuy Khanh Le-Trilling +4 more
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Distinct contributions of TNF receptor 1 and 2 to TNF-induced glomerular inflammation in mice. [PDF]
PLoS ONE, 2013 TNF is an important mediator of glomerulonephritis. The two TNF-receptors TNFR1 and TNFR2 contribute differently to glomerular inflammation in vivo, but specific mechanisms of TNFR-mediated inflammatory responses in glomeruli are unknown. We investigated
Anela Taubitz +4 more
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Colocalization of endogenous TNF with a functional intracellular splice form of human TNF receptor type 2 [PDF]
Journal of Inflammation, 2005 Background Tumor necrosis factor (TNF) is a pleiotropic cytokine involved in a broad spectrum of inflammatory and immune responses including proliferation, differentiation, and cell death.
Schütze Stephan +4 more
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Tumor necrosis factor-α and lymphotoxin-α mediate myocardial ischemic injury via TNF receptor 1, but are cardioprotective when activating TNF receptor 2. [PDF]
PLoS ONE, 2013 This study determines the roles of tumor necrosis factor-α (TNFα) and lymphotoxin-α (LTα) in post-myocardial infarction (post-MI) cardiac injury, and identifies the TNF receptor type responsible for TNFα- and LTα-mediated cardiac injury.Adult male wild ...
Yanqing Zhang +10 more
doaj +4 more sources
Forward and Reverse Signaling Mediated by Transmembrane Tumor Necrosis Factor-Alpha and TNF Receptor 2: Potential Roles in an Immunosuppressive Tumor Microenvironment [PDF]
Frontiers in Immunology, 2017 Tumor necrosis factor-alpha (TNF-α) is a pleiotropic inflammatory cytokine produced mainly by activated macrophages, lymphocytes and other cell types. Two distinct forms of TNF-α have been identified: soluble TNF-α (sTNF-α) and transmembrane TNF-α (mTNF ...
Yang Qu +8 more
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