Results 41 to 50 of about 689,362 (298)

Reduction of circulating cholesterol and apolipoprotein levels during sepsis [PDF]

, 1999
Sepsis with multiple organ failure is frequently associated with a substantial decrease of cholesterol levels. This decrease of cholesterol is strongly associated with mortality suggesting a direct relation between inflammatory conditions and altered ...
Alvarez C, Chajek-Shaul T, Engelmann H, Ettinger WH, Ettinger WH, Ettinger WH, Feingold KR, Feingold KR, Flegel WA, Gouni I, Graham A, Greenberg AS, Grove RI, Grunfeld C, Hubsch AP, Ishibashi S, Kipp HA, Moran CS, Netea MG, Pacelli F, Pak YK, Read TE, Semb H, Stopeck AT, Van Gameren MM, Weinstock C, Wilson DE, Yokoyama K   +27 more
core   +1 more source

Susceptibility to pulmonary tuberculosis: host genetic deficiency in tumor necrosis factor alpha (TNF-α) gene and tumor necrosis factor receptor 2 (TNFR2)

International Journal of Mycobacteriology, 2016
Objective/Background: The susceptibility to tuberculosis (TB) depends upon different factors, and the risk of developing diseases after infection with Mycobacterium tuberculosis ranges from 5% to 10%.
Ehsan Ghamari, Poopak Farnia, Shima Saif, Mehran Marashian, Jaladein Ghanavi, Payam Tabarsi, Parissa Farnia, Ali Akbar Velayati   +7 more
doaj   +1 more source

Distinctive roles of tumor necrosis factor receptor type 1 and type 2 in a mouse disc degeneration model

Journal of Orthopaedic Translation, 2021
Background: Elevated tumor necrosis factor alpha (TNF-α) expression is correlated with the progression of intervertebral disc degeneration (IVDD). Progranulin binding to tumor necrosis factor receptor (TNFR) and its derivative Atsttrin are effective for ...
Shanzheng Wang, Guodong Sun, Pan Fan, Lei Huang, Yaofei Chen, Changhong Chen   +5 more
doaj   +1 more source

Glucocorticoid-induced microRNA-511 protects against TNF by down-regulating TNFR1 [PDF]

, 2015
TNF is a central actor during inflammation and a well-recognized drug target for inflammatory diseases. We found that the mouse strain SPRET/Ei, known for extreme and dominant resistance against TNF-induced shock, displays weak expression of TNF receptor
Dejager, Lien, Libert, Claude, Lodens, Sofie, Puimège, Leen, Staelens, Jan, Steeland, Sophie, Timmermans, Steven, Van Hauwermeiren, Filip, Van Ryckeghem, Sara, Vandenbroucke, Roosmarijn, Vandevyver, Sofie, Vandewalle, Jolien   +11 more
core   +1 more source

Selective death of autoreactive T cells in human diabetes by TNF or TNF receptor 2 agonism [PDF]

Proceedings of the National Academy of Sciences, 2008
Human autoimmune (AI) diseases are difficult to treat, because immunosuppressive drugs are nonspecific, produce high levels of adverse effects, and are not based on mechanistic understanding of disease. Destroying the rare autoreactive T lymphocytes causing AI diseases would improve treatment.
Liqin, Ban, Jack, Zhang, Limei, Wang, Willem, Kuhtreiber, Douglas, Burger, Denise L, Faustman   +5 more
openaire   +2 more sources

Resistance to cytotoxicity and sustained release of interleukin-6 and interleukin-8 in the presence of decreased interferon-γ after differentiation of glioblastoma by human natural killer cells. [PDF]

, 2016
Natural killer (NK) cells are functionally suppressed in the glioblastoma multiforme (GBM) tumor microenvironment. We have recently shown that survival and differentiation of cancer stem-like cells (CSCs)/poorly differentiated tumors are controlled ...
Bui, Vickie T, Cacalano, Nicholas, Inagaki, Akihito, Jewett, Anahid, Kasahara, Noriyuki, Kaur, Kawaljit, Kozlowska, Anna K, Topchyan, Paytsar, Tseng, Han-Ching   +8 more
core   +1 more source

Expression of TNF-α and Related Signaling Molecules in the Peripheral Blood Mononuclear Cells of Rheumatoid Arthritis Patients

Mediators of Inflammation, 2006
We examined the role of tumor necrosis factor (TNF-α) and its related signaling intermediates leading to apoptosis/proliferation in the peripheral blood mononuclear cells (PBMCs) of RA patients.
Sunil Kumar Raghav, Bhawna Gupta, Charu Agrawal, Ved P. Chaturvedi, Hasi R. Das   +4 more
doaj   +1 more source

The ubiquitin-editing enzyme A20 controls NK cell homeostasis through regulation of mTOR activity and TNF [PDF]

, 2019
The ubiquitin-editing enzyme A20 is a well-known regulator of immune cell function and homeostasis. In addition, A20 protects cells from death in an ill-defined manner.
Boon, Louis, De Prijck, Sofie, Deswarte, Kim, Fayazpour, Farzaneh, Janssens, Sophie, Lambrecht, Bart, Martens, Arne, Takahashi, Nozomi, Tavernier, Simon, van Helden, Mary, van Loo, Geert, Van Moorleghem, Justine, Vandenabeele, Peter, Vanheerswynghels, Manon, Vergote, Karl, Vetters, Jessica, Vivier, Eric, Wahlen, Sigrid   +17 more
core   +6 more sources

Role of Tumor Necrosis Factor (TNF) Receptor-associated Factor 2 (TRAF2) in Distinct and Overlapping CD40 and TNF Receptor 2/CD120b-mediated B Lymphocyte Activation [PDF]

Journal of Biological Chemistry, 2004
Members of the tumor necrosis factor receptor (TNFR) family play a variety of roles in the regulation of lymphocyte activation. An important TNFR family member for B cell activation is CD40. CD40 signals stimulate B cell TNF-alpha secretion, which subsequently signals via TNFR2 (CD120b) to enhance B cell activation.
Melissa E, Munroe, Gail A, Bishop
openaire   +2 more sources

Fatal Leishmaniasis in the Absence of TNF Despite a Strong Th1 Response

Frontiers in Microbiology, 2016
Induction of inducible nitric oxide synthase (iNOS) in mononuclear phagocytes by IFN-γ and innate tumor necrosis factor (TNF) provide the basis for an effective immune response to the intracellular parasite Leishmania (L.) major. We previously observed a
Phillip D Fromm, Jessica eKling, Annika eRemke, Christian eBogdan, Heinrich eKorner   +4 more
doaj   +1 more source