Results 51 to 60 of about 689,362 (298)

Toll-like receptor-mediated signaling cascade as a regulator of the inflammation network during alcoholic liver disease [PDF]

, 2014
Chronic abuse of alcohol leads to various histological abnormalities in the liver. These are conditions collectively known as alcoholic liver disease (ALD). Currently, ALD is considered to be one of the major causes of death worldwide.
Alisi, A., Ceccarelli, S, Nobili, V
core   +1 more source

Tumor Necrosis Factor (TNF) α Increases Collagen Accumulation and Proliferation in Intestinal Myofibroblasts via TNF Receptor 2 [PDF]

Journal of Biological Chemistry, 2005
Intestinal fibrosis is an incurable complication of Crohn's disease involving increased numbers of collagen-producing myofibroblasts. Tumor necrosis factor (TNF) alpha has defined proinflammatory roles in Crohn's disease but its role in fibrosis is unclear.
Arianne L, Theiss, James G, Simmons, Christian, Jobin, P Kay, Lund   +3 more
openaire   +2 more sources

Downregulation of liver X receptor-α in mouse kidney and HK-2 proximal tubular cells by LPS and cytokines

Journal of Lipid Research, 2005
The acute-phase response (APR) suppresses type II nuclear hormone receptors and alters the expression of their target genes involved in lipid metabolism in the liver and heart. Therefore, we examined the expression of liver X receptor/retinoid X receptor
Yuwei Wang, Arthur H. Moser, Judy K. Shigenaga, Carl Grunfeld, Kenneth R. Feingold   +4 more
doaj   +1 more source

Toll-like receptor signaling adapter proteins govern spread of neuropathic pain and recovery following nerve injury in male mice. [PDF]

, 2013
BackgroundSpinal Toll-like receptors (TLRs) and signaling intermediaries have been implicated in persistent pain states. We examined the roles of two major TLR signaling pathways and selected TLRs in a mononeuropathic allodynia.MethodsL5 spinal nerve ...
A Ledeboer, AI de la Llave-Rincon, AL Oaklander, AS Jaggi, BJ Marsh, C Erridge, C Fernandez-de-las-Penas, C Fernandez-de-las-Penas, CA Christianson, CC Bowman, CF Kim, CI Svensson, CR Stewart, CS Jack, D Kim, D Kim, F Kozin, F Marchand, FY Tanga, H Cao, H Hacker, H Hashizume, H Tsujino, H Yanai, I Bettoni, J Mika, J Zhang, JA DeLeo, JA Stokes, JA Stokes, Jennifer A Stokes, JL Hylden, JM Chung, Jonathan Cheung, K Hoebe, K Honda, K Hoshino, K Kariko, KA Cavassani, Kelly Eddinger, KH Konopka, L Cao, L Nicotra, L Znaor, LA O’Neill, LA Panagio, LH Guo, M Bsibsi, M Calvo, M Chacur, M Hossaini, M Koltzenburg, M Yamamoto, Maripat Corr, MR Hutchinson, MR Hutchinson, NE Saade, O Adachi, O Saito, O Takeuchi, P Hu, P Hu, Q Xu, Q Zhang, R Wang, RE Sorge, RG Chen, RG Zanon, S Akira, S Akira, S Hosmane, S Lehnardt, S Nadeau, S Pu, S Rivest, S Sakaguchi, SR Chaplan, SW Mitchell, T Kawai, T King, T Liu, T Shichita, T Tanaka, Tony L Yaksh, TW Vanderah, V Huge, V Raghavendra, V Raghavendra, XY Hua, Y Ohmichi, YR Wen   +90 more
core   +1 more source

Efficacy and Safety Analysis of Roxarestat in Regulating Renal Anemia in Patients on Maintenance Hemodialysis

Therapeutic Apheresis and Dialysis, EarlyView.
ABSTRACT Objective To compare the efficacy and safety of roxarestat versus recombinant human erythropoietin (rhEPO) in the management of renal anemia in patients undergoing maintenance hemodialysis. Methods This was a prospective, open‐label, randomized controlled trial.
Lingling Chen, Junjie Zhu, Qiaonan Ge
wiley   +1 more source

Inhibition of soluble tumor necrosis factor ameliorates synaptic alterations and Ca2+ dysregulation in aged rats.

PLoS ONE, 2012
The role of tumor necrosis factor α (TNF) in neural function has been investigated extensively in several neurodegenerative conditions, but rarely in brain aging, where cognitive and physiologic changes are milder and more variable.
Diana M Sama, Hafiz Mohmmad Abdul, Jennifer L Furman, Irina A Artiushin, David E Szymkowski, Stephen W Scheff, Christopher M Norris   +6 more
doaj   +1 more source

Stimulation of microglial metabotropic glutamate receptor mGlu2 triggers tumor necrosis factor alpha-induced neurotoxicity in concert with microglial-derived fas ligand [PDF]

, 2005
Activated microglia may be detrimental to neuronal survival in a number of neurodegenerative diseases. Thus, strategies that reduce microglial neurotoxicity may have therapeutic benefit.
Jones, F, Kubota, ESFCS, Pocock, JM, Taylor, DL   +3 more
core  

Hypoxia Preconditioning Increases Survival and Decreases Expression of Toll-like Receptor 4 in Pulmonary Artery Endothelial Cells Exposed to Lipopolysaccharide [PDF]

, 2013
Pulmonary or systemic infections and hypoxemic respiratory failure are among the leading causes of admission to intensive care units, and these conditions frequently exist in sequence or in tandem.
Ali, Irshad, Audi, Said H., Densmore, John C., Husnain, Fouad, Jacobs, Elizabeth R., Konduri, G. Ganesh, Medhora, Meetha, Nanchal, Rahul   +7 more
core   +2 more sources

Inactivity‐induced phrenic motor facilitation is initiated though TNF receptor 2 and impaired by TNF receptor 1

The FASEB Journal, 2016
Prolonged reductions in synaptic inputs to phrenic motor neurons results in the release of spinal, soluble TNFα (sTNFα) to initiate a long lasting increase in phrenic burst amplitude termed inactivity‐induced phrenic motor facilitation (iPMF). TNFα can activate TNF‐R1 or TNF‐R2, which are two distinct cell surface receptors that tend to initiate ...
Kendra Braegelmann, Stephanie Fischer, Abiye Agbeh, Tracy Baker   +3 more
openaire   +1 more source

Differential regulation of TNF receptor 1 and receptor 2 in adiponectin expression following myocardial ischemia [PDF]

International Journal of Cardiology, 2013
In vitro experiments demonstrate that adiponectin, a cardioprotective cytokine, is inhibited by tumor necrosis factor-alpha (TNFα). However, the role of TNFα in post-myocardial infarction (post-MI) adiponectin reduction remains unclear. More importantly, the TNF receptor type (TNFR1 or TNFR2) responsible for TNFα-mediated suppression of adiponectin ...
Yajing, Wang, Jianli, Zhao, Yanqing, Zhang, Wayne Bond, Lau, Li-Yuan, Jiao, Baojiang, Liu, Yuexing, Yuan, Xiaoliang, Wang, Ling, Tao, Erhe, Gao, Walter J, Koch, Xin-Liang, Ma   +11 more
openaire   +2 more sources