Apoptotic epitope-specific CD8+ T cells and interferon signaling intersect in chronic hepatitis C virus infection [PDF]
, 2015 CD8(+) T cells specific to caspase-cleaved antigens derived from apoptotic T cells represent a principal player in chronic immune activation (CIA). Here, we found that both apoptotic epitope (AE)-specific and hepatitis C virus (HCV)-specific CD8(+) T ...
Accapezzato, Daniele +18 more
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Association of TNF-R2 (676T>G) single nucleotide polymorphism with head and neck cancer risk in the Serbian population [PDF]
Archives of Biological Sciences, 2013 Tumor necrosis factor (TNF) which exerts its effects through two different receptors known as TNF-R1 and TNF-R2, is a major proinflammatory cytokine involved in the pathogenesis of different types of tumors.
Kostić Marija +6 more
doaj +1 more source
Lipopolysaccharide- TLR-4 Axis regulates Osteoclastogenesis independent of RANKL/RANK signaling
BMC Immunology, 2021 Background Lipopolysaccharide (LPS) is an endotoxin and a vital component of gram-negative bacteria’s outer membrane. During gram-negative bacterial sepsis, LPS regulates osteoclast differentiation and activity, in addition to increasing inflammation ...
Mohammed S. AlQranei +4 more
doaj +1 more source
Glucocorticoid Receptor Maintains Vasopressin Responses in Kidney Collecting Duct Cells
Frontiers in Physiology, 2022 Water permeability of the kidney collecting ducts is regulated in part by the amount of the molecular water channel protein aquaporin-2 (AQP2), whose expression, in turn, is regulated by the pituitary peptide hormone vasopressin.
Hsiu-Hui Yang +5 more
doaj +1 more source
Novel anti-tumour necrosis factor receptor-1 (TNFR1) domain antibody prevents pulmonary inflammation in experimental acute lung injury. [PDF]
, 2018 BACKGROUND: Tumour necrosis factor alpha (TNF-α) is a pleiotropic cytokine with both injurious and protective functions, which are thought to diverge at the level of its two cell surface receptors, TNFR1 and TNFR2.
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Bone Marrow-Derived IL-1Ra Increases TNF Levels Poststroke
Cells, 2021 Tumor necrosis factor (TNF) and interleukin-1 receptor antagonist (IL-1Ra) are key players in stroke, a disease in which cell-based therapies have shown great potential.
Christian Ulrich von Linstow +6 more
doaj +1 more source
Journal of Neuroinflammation, 2011 Background The release of tumor necrosis factor-α (TNF-α) appears depend on the P2X7 receptor, a purinergic receptor. In the present study, we addressed the question of whether P2X7 receptor-mediated TNF-α regulation is involved in pathogenesis and ...
Ryu Hea Jin, Kim Ji-Eun, Kang Tae-Cheon
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UVB-induced association of tumor necrosis factor (TNF) receptor 1/TNF receptor-associated factor-2 mediates activation of Rel proteins [PDF]
Proceedings of the National Academy of Sciences, 1998 Exposure of mammalian skin to UV light results in induced gene transcription, playing a role in inflammation, immunosuppression, and tumor promotion. One important group of transcription factors induced by UV radiation is composed of members of the Rel/NF-κB family, which are known to play a major role in the transcriptional activation of many genes ...
D, Tobin +2 more
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Clinical and functional characterisation of a novel TNFRSF1A c.605T > A/V173D cleavage site mutation associated with tumour necrosis factor receptor-associated periodic fever syndrome (TRAPS), cardiovascular complications and excellent response to etanercept treatment. [PDF]
, 2008 Objectives: To study the clinical outcome, treatment response, T-cell subsets and functional consequences of a novel tumour necrosis factor (TNF) receptor type 1 (TNFRSF1A) mutation affecting the receptor cleavage site.
B H Belohradsky +7 more
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Requirement of TNF and TNF receptor type 2 for LPS-induced protection from lethal septic peritonitis [PDF]
Journal of Endotoxin Research, 2002 Pretreatment of mice with low quantities of LPS induces endotoxin t olerance characterized by enhanced resistance to lethal doses of LPS and to a number of infectious challenges. M ice subjected to cecal ligation and puncture (CLP) survived the ensuing septic peritonitis significantly better when they had been pretreated with LPS.
Bernd, Echtenacher, Daniela N, Männel
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