Results 11 to 20 of about 689,362 (298)

TNF Receptor Associated Factor 2 (TRAF2) Signaling in Cancer [PDF]

Cancers, 2022
Tumor necrosis factor (TNF) receptor associated factor-2 (TRAF2) has been originally identified as a protein interacting with TNF receptor 2 (TNFR2) but also binds to several other receptors of the TNF receptor superfamily (TNFRSF). TRAF2, often in concert with other members of the TRAF protein family, is involved in the activation of the classical ...
Daniela Siegmund, Jennifer Wagner, Harald Wajant   +2 more
openaire   +2 more sources

Co-expression of TNF receptors 1 and 2 on melanomas facilitates soluble TNF-induced resistance to MAPK pathway inhibitors

Journal of Translational Medicine, 2022
Background The effectiveness of MAPK pathway inhibitors (MAPKi) used to treat patients with BRAF-mutant melanoma is limited by a range of resistance mechanisms, including soluble TNF (solTNF)-mediated NF-kB signaling.
Cindy A. Sander, Elizabeth A. Rush, Jian Shi, Lidia M. R. B. Arantes, Raymond J. Tesi, Mark A. Ross, Michael J. Calderon, Simon C. Watkins, John M. Kirkwood, Robert L. Ferris, Lisa H. Butterfield, Lazar Vujanovic   +11 more
doaj   +1 more source

Both functional LTbeta receptor and TNF receptor 2 are required for the development of experimental cerebral malaria. [PDF]

PLoS ONE, 2008
BackgroundTNF-related lymphotoxin alpha (LTalpha) is essential for the development of Plasmodium berghei ANKA (PbA)-induced experimental cerebral malaria (ECM). The pathway involved has been attributed to TNFR2.
Dieudonnée Togbe, Paulo Loureiro de Sousa, Mathilde Fauconnier, Victorine Boissay, Lizette Fick, Stefanie Scheu, Klaus Pfeffer, Robert Menard, Georges E Grau, Bich-Thuy Doan, Jean Claude Beloeil, Laurent Renia, Anna M Hansen, Helen J Ball, Nicholas H Hunt, Bernhard Ryffel, Valerie F J Quesniaux   +16 more
doaj   +1 more source

Cytokine tuning of intestinal epithelial function [PDF]

, 2018
The intestine serves as both our largest single barrier to the external environment and the host of more immune cells than any other location in our bodies.
Andrews, Caroline, Durum, Scott K., McLean, Mairi H.   +2 more
core   +10 more sources

Apoptosis and upregulation of TNF-α and TRAIL receptor 1 (DR4) in the pathogenesis of food protein-induced enterocolitis syndrome [PDF]

Korean Journal of Pediatrics, 2010
Purpose : Expression levels of tumor necrosis factor (TNF)-?#6181;xpression on the mucosa of the small intestine is increased in patients with villous atrophy in food protein-induced enterocolitis syndrome (FPIES).
Jin-Bok Hwang, Sang Pyo Kim, Yu Na Kang, Seong-Ryong Lee, Seong-Il Suh, Taeg Kyu Kwon   +5 more
doaj   +1 more source

A TNF receptor 2 selective agonist rescues human neurons from oxidative stress-induced cell death. [PDF]

PLoS ONE, 2011
Tumor necrosis factor (TNF) plays a dual role in neurodegenerative diseases. Whereas TNF receptor (TNFR) 1 is predominantly associated with neurodegeneration, TNFR2 is involved in tissue regeneration and neuroprotection.
Roman Fischer, Olaf Maier, Martin Siegemund, Harald Wajant, Peter Scheurich, Klaus Pfizenmaier   +5 more
doaj   +1 more source

Membrane Tumor Necrosis Factor (TNF) Induces p100 Processing via TNF Receptor-2 (TNFR2) [PDF]

Journal of Biological Chemistry, 2010
Tumor necrosis factor (TNF) elicits its biological activities by stimulation of two receptors, TNFR1 and TNFR2, both belonging to the TNF receptor superfamily. Whereas TNFR1-mediated signal transduction has been intensively studied and is understood in detail, especially with respect to activation of the classical NFkappaB pathway, cell death induction,
Hilka, Rauert, Andreas, Wicovsky, Nicole, Müller, Daniela, Siegmund, Volker, Spindler, Jens, Waschke, Christian, Kneitz, Harald, Wajant   +7 more
openaire   +2 more sources

TNF RECEPTOR 2, NOT TNF RECEPTOR 1, ENHANCES MESENCHYMAL STEM CELL-MEDIATED CARDIAC PROTECTION FOLLOWING ACUTE ISCHEMIA [PDF]

Shock, 2010
Mesenchymal stem cells (MSCs) may improve myocardial function after I/R injury via paracrine effects, including the release of growth factors. Genetic modification of MSCs is an appealing method to enhance MSC paracrine action. Ablation of TNF receptor 1 (TNFR1), but not TNFR2, increases MSC growth factor production.
Megan L, Kelly, Meijing, Wang, Paul R, Crisostomo, Aaron M, Abarbanell, Jeremy L, Herrmann, Brent R, Weil, Daniel R, Meldrum   +6 more
openaire   +2 more sources

Role of tumor necrosis factor-alpha in the central nervous system: a focus on autoimmune disorders

Frontiers in Immunology, 2023
Tumor necrosis factor-alpha (TNF-α) is a pleiotropic immune cytokine that belongs to the TNF superfamily of receptor ligands. The cytokine exists as either a transmembrane or a soluble molecule, and targets two distinct receptors, TNF-α receptor 1 (TNFR1)
Natalia Gonzalez Caldito
doaj   +1 more source

Tumor necrosis factor (TNF) receptor type 2 mediates thymocyte proliferation independently of TNF receptor type 1 [PDF]

European Journal of Immunology, 1998
Tumor necrosis factor (TNF) mediates its biological effects by binding to two distinct but homologous receptor molecules. The type 1 receptor (TNF-R1) has been shown to be essential and sufficient for most cellular responses to soluble TNF. In contrast, only limited data exist concerning the role of the type 2 receptor (TNF-R2) in TNF responses, both ...
M, Grell, F M, Becke, H, Wajant, D N, Männel, P, Scheurich   +4 more
openaire   +2 more sources