Transmembrane tumor necrosis factor alpha attenuates pressure-overload cardiac hypertrophy via tumor necrosis factor receptor 2. [PDF]
PLoS Biology, 2020 Tumor necrosis factor-alpha (TNF-α) plays an important pathogenic role in cardiac hypertrophy and heart failure (HF); however, anti-TNF is paradoxically negative in clinical trials and even worsens HF, indicating a possible protective role of TNF-α in HF.
Kun Miao +9 more
doaj +5 more sources
Tumor necrosis factor receptor 2 in allergen tolerance: a perspective view [PDF]
Frontiers in ImmunologyCentral and peripheral tolerance are key to maintain immune homeostasis. Imbalance of these processes often leads to diseases such as allergy, cancer or autoimmune disorders. During the immune response to allergens, several regulatory immune cells play a
Guillem Montamat-Garcia +7 more
doaj +3 more sources
Interference of tumor necrosis factor inhibitor treatments on soluble tumor necrosis factor receptor 2 levels in rheumatoid arthritis [PDF]
Practical Laboratory Medicine, 2019 Objective: Soluble Tumor Necrosis Factor Receptor II (sTNFR2) is used as a biomarker to study cardiovascular disease (CVD) in diverse populations. TNF inhibitors (TNFi's) are a common treatment for inflammatory conditions. The objective of this study was
Nicole Yang +8 more
doaj +4 more sources
Novel strategies to mimic transmembrane tumor necrosis factor-dependent activation of tumor necrosis factor receptor 2 [PDF]
Scientific Reports, 2017 Tumor necrosis factor receptor 2 (TNFR2) is known to mediate immune suppression and tissue regeneration. Interestingly, the transmembrane form of tumor necrosis factor (tmTNF) is necessary to robustly activate TNFR2. To characterize the stoichiometry and
Roman Fischer +7 more
doaj +4 more sources
TNF Receptor 2 Makes Tumor Necrosis Factor a Friend of Tumors [PDF]
Frontiers in Immunology, 2018 Tumor necrosis factor (TNF) is widely accepted as a tumor-suppressive cytokine via its ubiquitous receptor TNF receptor 1 (TNFR1). The other receptor, TNFR2, is not only expressed on some tumor cells but also on suppressive immune cells, including ...
Yuqiao Sheng, Feng Li, Zhihai Qin
doaj +3 more sources
Activation of tumor necrosis factor receptor 1 in airway smooth muscle: a potential pathway that modulates bronchial hyper-responsiveness in asthma? [PDF]
Respiratory Research, 2000 The cellular and molecular mechanisms that are involved in airway hyper-responsiveness are unclear. Current studies suggest that tumor necrosis factor (TNF)-α, a cytokine that is produced in considerable quantities in asthmatic airways, may potentially ...
Panettieri Reynold A +2 more
doaj +2 more sources
Tumor Necrosis Factor Receptor 2 (TNFR2): An Emerging Target in Cancer Therapy. [PDF]
Cancers (Basel), 2022 Despite the great success of TNF blockers in the treatment of autoimmune diseases and the identification of TNF as a factor that influences the development of tumors in many ways, the role of TNFR2 in tumor biology and its potential suitability as a therapeutic target in cancer therapy have long been underestimated.
Medler J, Kucka K, Wajant H.
europepmc +4 more sources
Soluble tumor necrosis factor receptor 2 is associated with progressive diabetic kidney disease in patients with type 2 diabetes mellitus. [PDF]
PLoS ONE, 2022 BackgroundChronic low-grade inflammation is considered one of the major mechanisms for the progression of diabetic kidney disease. We investigated the prognostic value of circulating soluble tumor necrosis factor receptor 2 (sTNFR2) for early nephropathy
Tsung-Hui Wu +5 more
doaj +4 more sources
Clinical implications of tumor necrosis factor receptor 2 in breast cancer. [PDF]
Oncol Lett, 2017 Tumor necrosis factor receptor 2 (TNFR2) is a member of the tumor necrosis factor receptor family. Its high expression and oncogenic roles have been reported in several types of tumors in previous years. However, the clinical implication of TNFR2 in breast cancer (BC) tissue (i.e., not soluble TNFR2 in blood or genetic variation of TNFR2) has not been ...
Yang F, Zhao Z, Zhao N.
europepmc +4 more sources
Colitis-induced upregulation of tumor necrosis factor receptor-2 (TNFR2) terminates epithelial regenerative signaling to restore homeostasis [PDF]
iScience, 2023 Summary: Colonic epithelial repair is a key determinant of health. Repair involves changes in epithelial differentiation, an extensive proliferative response, and upregulation of regeneration-associated “fetal-like” transcripts, including Ly6a (Sca-1 ...
Zohreh Sharifkhodaei +6 more
doaj +2 more sources