Results 41 to 50 of about 29,380,860 (288)

The tumor necrosis factor receptor 2 signal transducers TRAF2 and c-IAP1 are components of the tumor necrosis factor receptor 1 signaling complex [PDF]

Proceedings of the National Academy of Sciences, 1996
The two cell surface receptors for tumor necrosis factor (TNF) interact with a number of intracellular signal transducing proteins. The association of TRADD, a 34-kDa cytoplasmic protein containing a C-terminal death domain, with aggregated TNF receptor 1 (TNF-R1) through their respective death domains leads to NF-κB activation and programmed cell ...
H B, Shu, M, Takeuchi, D V, Goeddel
openaire   +2 more sources

Enhanced Microglia Activation and Glioma Tumor Progression by Inflammagen Priming in Mice with Tumor Necrosis Factor Receptor Type 2 Deficiency

Life, 2021
Despite the fact that accumulation of microglia, the resident macrophages of the central nervous system (CNS) are the main feature of glioblastoma, the role of microglia in the progression of glioma is still arguable.
Chih-Kai Liao, Kuan-Min Fang, Hui-Ting Huang, Wen-Ruei Chang, Chao-Chi Chuang, Shun-Fen Tzeng   +5 more
doaj   +1 more source

Screening of the human tumor necrosis factor (TNF) gene and its receptor 1 (TNFR1) gene for DNA alterations and the subsequent investigation of these and an IL12p40 polymorphism for an association with paediatric tuberculosis [PDF]

, 2004
Includes bibliographical references (leaves 85-96).Infection with Mycobacterium tuberculosis is characterised by diverse outcomes; the majority of infected individuals remain well and yet others develop disease ranging from limited pulmonary tuberculosis
Lampel, Netanya
core   +1 more source

Recent updates in the clinical trials of therapeutic monoclonal antibodies targeting cytokine storm for the management of COVID-19

Heliyon, 2021
Clinical studies have identified a cytokine storm in the third stage of disease progression in critical ill patients with coronavirus disease 2019 (COVID-19). Hence, effectively suppressing the uncontrolled immune response of the host towards the invaded
Shikha Patel, Bhagawati Saxena, Priti Mehta   +2 more
doaj   +1 more source

Modulation of autocrine TNF-α-stimulated matrix metalloproteinase 9 (MMP-9) expression by mitogenactivated protein kinases in THP-1 monocytic cells [PDF]

, 2006
Matrix metalloproteinase 9 (MMP-9) is implicated in various physiological processes by its ability to degrade the extracellular matrix (ECM) and process multiple regulatory proteins. Normally, MMP-9 expression is tightly controlled in cells. Sustained or
Helmut Kolb, Krell, Hans-Willi, Kolb, Helmut, Heidinger, Michael, Michael Heidinger, Hans-Willi Krell, Marianne Jochum, Jochum, Marianne, Christian Ries, Ries, Christian   +9 more
core   +1 more source

Activation of tumor necrosis factor receptor 1 in airway smooth muscle: a potential pathway that modulates bronchial hyper-responsiveness in asthma?

Respiratory Research, 2000
The cellular and molecular mechanisms that are involved in airway hyper-responsiveness are unclear. Current studies suggest that tumor necrosis factor (TNF)-α, a cytokine that is produced in considerable quantities in asthmatic airways, may potentially ...
Panettieri Reynold A, Chen Hang, Amrani Yassine   +2 more
doaj   +1 more source

Behavior of Tumor Necrosis Factor-α and Tumor Necrosis Factor Receptor 1/Tumor Necrosis Factor Receptor 2 System in Mononuclear Cells Recovered From Peritoneal Fluid of Women With Endometriosis at Different Stages [PDF]

Reproductive Sciences, 2015
During endometriosis, a breakdown occurs in endometrial and peritoneal homeostasis caused by cytokine-induced cell proliferation and dysregulation of apoptosis. We studied tumor necrosis factor (TNF)-α, TNF receptor (TNFR) 1, and TNFR2 gene expression at both messenger RNA (mRNA) and protein levels in peritoneal fluid (PF) mononuclear cells (PFMCs ...
SALMERI, Francesca Maria, LAGANA', ANTONIO SIMONE, SOFO, Vincenza, TRIOLO, Onofrio, STURLESE, Emanuele, RETTO, Giovanni, PIZZO, Alfonsa, D'ASCOLA, ANGELA, CAMPO, Salvatore Giuseppe   +8 more
openaire   +3 more sources

Changes in expression of TNF alpha and its receptors mRNAs in oocytes and granulosa cells in mice with experimental immune ovarian failure [PDF]

, 2014
Purpose: To investigate the expression of TNF- α and its receptors (types I and II) at mRNA level in oocytes and granulose cells as well as to study effect of TNF-α on follicular cell death in mice with experimental immune ovarian failure induced by ...
Grushka, Nataliya, Dosenko, Victor, Shepel, Elena, Voznesenskaya, Tatyana, Yanchiy, Roman   +4 more
core   +1 more source

Pathogenicity and virulence of Japanese encephalitis virus: Neuroinflammation and neuronal cell damage

Virulence, 2021
Thousands of human deaths occur annually due to Japanese encephalitis (JE), caused by Japanese encephalitis virus. During the virus infection of the central nervous system, reactive gliosis, uncontrolled inflammatory response, and neuronal cell death are
Usama Ashraf, Zhen Ding, Shunzhou Deng, Jing Ye, Shengbo Cao, Zheng Chen   +5 more
doaj   +1 more source

Distinct Mechanisms for Induction and Tolerance Regulate the Immediate Early Genes Encoding Interleukin 1β and Tumor Necrosis Factor α [PDF]

, 2013
Interleukin-1β and Tumor Necrosis Factor α play related, but distinct, roles in immunity and disease. Our study revealed major mechanistic distinctions in the Toll-like receptor (TLR) signaling-dependent induction for the rapidly expressed genes (IL1B ...
Unlu, Sebnem, Gillian M. Tannahill (440532), O’Neill Luke A., Kent Z. Q. Wang (440530), Kent Z. Q. Wang, Galson, Deborah L., Galson Deborah L., Luke A. O’Neill (440534), Tannahill Gillian M., Auron Philip E., O'Neill, LA, Adamik, Juraj, Su An-Jey A., Gillian M. Tannahill, Sebnem Unlu, Philip E. Auron, Unlu Sebnem, Gillian M Tannahill, Adamik, J, An-Jey A. Su, Yan, Chunhong, Auron, PE, Deborah L. Galson, Luke A. O’Neill, Luke A O'Neill, O’Neill, Luke A., Su, AJA, Tannahill, GM, An-Jey A. Su (440531), O\u27Neill, Luke A., Deborah L Galson, Wang, KZQ, An-Jey A Su, Kent Z Q Wang, Unlu, S, Sebnem Unlu (156119), Wang, Kent Z. Q., Juraj Adamik (440529), Galson, DL, Adamik Juraj, Philip E. Auron (440535), Philip E Auron, Wang Kent Z. Q., Su, An Jey A., Tannahill, Gillian M., Su, An-Jey A., Wang, Kent Z.Q., Deborah L. Galson (440533), Auron, Philip E., Juraj Adamik   +49 more
core   +1 more source