Results 21 to 30 of about 589,523 (288)

Tumor Necrosis Factor Receptor–Associated Factor 2 Mediates Mitochondrial Autophagy [PDF]

Circulation: Heart Failure, 2015
Background— Tumor necrosis factor (TNF) signaling protects against ischemia/reperfusion–induced cardiomyocyte death, in vitro, ex vivo, and in vivo. TNF-receptor–associated factor 2 (TRAF2), an E3 ubiquitin ligase, coordinates cytoprotective signaling downstream of both TNF receptors, via unclear mechanisms.
Kai-Chun, Yang, Xiucui, Ma, Haiyan, Liu, John, Murphy, Philip M, Barger, Douglas L, Mann, Abhinav, Diwan   +6 more
openaire   +2 more sources

Expression of tumor necrosis factor-alpha receptor 2 and interleukin-1 in middle ear cholesteatoma [PDF]

Vojnosanitetski Pregled, 2021
Background/Aim. Cholesteatoma is characterized by progressive growth with the erosion of surrounding bone due to pressure effects, enzymatic activity and activation of osteoclasts.
Vranješ Dalibor, Spremo Slobodan, Gajanin Radoslav, Špirić Sanja, Amidžić Ljiljana, Novaković-Bursać Snježana   +5 more
doaj   +1 more source

Choroid plexus tumor necrosis factor receptor 1: A new neuroinflammatory piece of the complex Alzheimer’s disease puzzle

Neural Regeneration Research, 2019
Due to the aging of the population and despite the enormous scientific effort, Alzheimer’s disease remains one of the biggest medical and pharmaceutical challenges in current medicine.
Sophie Steeland, Roosmarijn E Vandenbroucke   +1 more
doaj   +1 more source

Membrane lymphotoxin-α2β is a novel tumor necrosis factor (TNF) receptor 2 (TNFR2) agonist

Cell Death and Disease, 2021
In the early 1990s, it has been described that LTα and LTβ form LTα2β and LTαβ2 heterotrimers, which bind to TNFR1 and LTβR, respectively. Afterwards, the LTαβ2–LTβR system has been intensively studied while the LTα2β–TNFR1 interaction has been ignored ...
Kirstin Kucka, Isabell Lang, Tengyu Zhang, Daniela Siegmund, Juliane Medler, Harald Wajant   +5 more
doaj   +1 more source

Cardiovascular hemodynamics in mice with tumor necrosis factor receptor—associated factor 2 mediated cytoprotection in the heart

Frontiers in Cardiovascular Medicine, 2023
IntroductionMany studies in mice have demonstrated that cardiac-specific innate immune signaling pathways can be reprogrammed to modulate inflammation in response to myocardial injury and improve outcomes.
Andrea G. Marshall, Kit Neikirk, Zer Vue, Heather K. Beasley, Edgar Garza-Lopez, Larry Vang, Taylor Barongan, Zoe Evans, Amber Crabtree, Elsie Spencer, Josephs Anudokem, Josephs Anudokem, Remi Parker, Remi Parker, Jamaine Davis, Dominique Stephens, Dominique Stephens, Steven Damo, Thuy T. Pham, Jose A. Gomez, Vernat Exil, Vernat Exil, Dao-fu Dai, Sandra A. Murray, Mark L. Entman, George E. Taffet, Antentor O. Hinton, Anilkumar K. Reddy   +27 more
doaj   +1 more source

Role of tumor necrosis factor-α and its receptors in diesel exhaust particle-induced pulmonary inflammation [PDF]

, 2017
Inhalation of diesel exhaust particles (DEP) induces an inflammatory reaction in the lung. However, the underlying mechanisms remain to be elucidated. Tumor necrosis factor alpha (TNF-alpha) is a proinflammatory cytokine that operates by binding to tumor
Boon, Louis, Joos, Guy, Kumar, Smitha, Maes, Tania, Provoost, Sharen, Tournoy, Kurt   +5 more
core   +3 more sources

Tumor necrosis factor alpha improves glucose homeostasis in diabetic mice independent with tumor necrosis factor receptor 1 and tumor necrosis factor receptor 2

Endocrine Journal, 2018
Type 2 diabetes is a serious threat to human health all over the world. It is particularly important to look for the pathogenesis of type 2 diabetes. Researchers have found that obesity was associated with a broad chronic inflammatory response and type 2 diabetes.
Shanshan, Wu, Kai, Dong, Jiajia, Wang, Yaxin, Bi   +3 more
openaire   +3 more sources

Clinical and functional characterisation of a novel TNFRSF1A c.605T > A/V173D cleavage site mutation associated with tumour necrosis factor receptor-associated periodic fever syndrome (TRAPS), cardiovascular complications and excellent response to etanercept treatment. [PDF]

, 2008
Objectives: To study the clinical outcome, treatment response, T-cell subsets and functional consequences of a novel tumour necrosis factor (TNF) receptor type 1 (TNFRSF1A) mutation affecting the receptor cleavage site.
B H Belohradsky, C Dejaco, C Duftner, K Huss, M Herold, M Schirmer, P Lohse, S Stojanov   +7 more
core   +1 more source

Tumor necrosis factor receptor 2 mRNA in rat models of hypertension [PDF]

American Journal of Hypertension, 2003
In human hypertension (HT) plasma tumor necrosis factor (TNF-alpha) and soluble TNF receptor 2 fragment (sTNF-R2) are increased, and the TNF-R2 gene (TNFRSF1B) has been implicated. Therefore, we measured Tnfr2 mRNA in kidney, adrenal, heart, and aorta from rats with ACTH-induced, corticosterone-induced, and spontaneous HT (SHR), and tested the effect ...
Lin, Ruby, Schyvens, Chris, Zhang, Yi, Whitworth, Judith, Morris, Brian   +4 more
openaire   +3 more sources

Roles of Tumor Necrosis Factor-α and Tumor Necrosis Factor-α Receptor 2 in Inflammation-Related Diseases

Journal of Pharmaceutical Research International, 2021
The aim of the present review is to provide basic knowledge about the role of tumour necrosis factor-α 1 and tumor necrosis factor-α receptor 2 in neuro-inflammation diseases. We performed an open-ended, English restricted search of PubMed, Embase, PsychINFO, Web of Science, Scopus, and the Cochrane Library for available literature from 24Feb.
Sadia Qamar Arain, Arshad Hussain Laghari, Farhatullah Kandhro, Abdul Hameed Lanjwani, Muhammad Raza Memon, Maaz Khan, Nazakat Hussain Memon   +6 more
openaire   +2 more sources