Results 21 to 30 of about 29,380,860 (288)

Membrane lymphotoxin-α2β is a novel tumor necrosis factor (TNF) receptor 2 (TNFR2) agonist

Cell Death and Disease, 2021
In the early 1990s, it has been described that LTα and LTβ form LTα2β and LTαβ2 heterotrimers, which bind to TNFR1 and LTβR, respectively. Afterwards, the LTαβ2–LTβR system has been intensively studied while the LTα2β–TNFR1 interaction has been ignored ...
Kirstin Kucka, Isabell Lang, Tengyu Zhang, Daniela Siegmund, Juliane Medler, Harald Wajant   +5 more
doaj   +1 more source

Cardiovascular hemodynamics in mice with tumor necrosis factor receptor—associated factor 2 mediated cytoprotection in the heart

Frontiers in Cardiovascular Medicine, 2023
IntroductionMany studies in mice have demonstrated that cardiac-specific innate immune signaling pathways can be reprogrammed to modulate inflammation in response to myocardial injury and improve outcomes.
Andrea G. Marshall, Kit Neikirk, Zer Vue, Heather K. Beasley, Edgar Garza-Lopez, Larry Vang, Taylor Barongan, Zoe Evans, Amber Crabtree, Elsie Spencer, Josephs Anudokem, Josephs Anudokem, Remi Parker, Remi Parker, Jamaine Davis, Dominique Stephens, Dominique Stephens, Steven Damo, Thuy T. Pham, Jose A. Gomez, Vernat Exil, Vernat Exil, Dao-fu Dai, Sandra A. Murray, Mark L. Entman, George E. Taffet, Antentor O. Hinton, Anilkumar K. Reddy   +27 more
doaj   +1 more source

The mitogenic potential of heparin-binding epidermal growth factor in the human endometrium is mediated by the epidermal growth factor receptor and is modulated by tumor necrosis factor-alpha [PDF]

, 2002
Heparin-binding epidermal growth factor (HB-EGF), a member of the epidermal growth factor (EGF) family, is implicated in a variety of biological processes, including reproduction.
Mardon, Helen J., Yoo, Hyung-J, Katya Chobotova, Barlow, David, Helen J. Mardon, Carver, J, Chobotova, K, Muchmore, ME, William J. Gullick, Muchmore, Mary-Elizabeth, Chobotova, Katya, Janet Carver, Yoo, HJ, Hyung-J Yoo, David H. Barlow, Manek, Sanjiv, Sanjiv Manek, Manek, S, Barlow, DH, Mary-Elizabeth Muchmore, Gullick, WJ, Gullick, William J., Carver, Janet, Mardon, HJ   +23 more
core   +1 more source

Tumor Necrosis Factor Receptor–Associated Factor 2 Mediates Mitochondrial Autophagy [PDF]

Circulation: Heart Failure, 2015
Background— Tumor necrosis factor (TNF) signaling protects against ischemia/reperfusion–induced cardiomyocyte death, in vitro, ex vivo, and in vivo. TNF-receptor–associated factor 2 (TRAF2), an E3 ubiquitin ligase, coordinates cytoprotective signaling downstream of both TNF receptors, via unclear mechanisms.
Kai-Chun, Yang, Xiucui, Ma, Haiyan, Liu, John, Murphy, Philip M, Barger, Douglas L, Mann, Abhinav, Diwan   +6 more
openaire   +2 more sources

The Role of Costimulatory Receptors of the Tumour Necrosis Factor Receptor Family in Atherosclerosis [PDF]

, 2012
Atherosclerosis is a chronic inflammatory disease that is mediated by both the innate and adaptive immune responses. T lymphocytes, that together with B cells are the cellular effectors of the adaptive immune system, are currently endowed with crucial ...
Ricardo F. Antunes, Dumitriu, Ingrid E; id_orcid, Kaski, JC, Antunes, Ricardo F, Juan Carlos Kaski, Kaski, Juan Carlos, Dumitriu, IE, Ingrid E. Dumitriu, Antunes, RF   +8 more
core   +1 more source

Tumor necrosis factor alpha improves glucose homeostasis in diabetic mice independent with tumor necrosis factor receptor 1 and tumor necrosis factor receptor 2

Endocrine Journal, 2018
Type 2 diabetes is a serious threat to human health all over the world. It is particularly important to look for the pathogenesis of type 2 diabetes. Researchers have found that obesity was associated with a broad chronic inflammatory response and type 2 diabetes.
Wu, Shanshan, Dong, Kai, Wang, Jiajia, Bi, Yaxin   +3 more
openaire   +3 more sources

A Role for Tumor Necrosis Factor Receptor-2 and Receptor-interacting Protein in Programmed Necrosis and Antiviral Responses [PDF]

Journal of Biological Chemistry, 2003
Members of the tumor necrosis factor (TNF) receptor (TNFR) superfamily are potent regulators of apoptosis, a process that is important for the maintenance of immune homeostasis. Recent evidence suggests that TNFR-1 and Fas and TRAIL receptors can also trigger an alternative form of cell death that is morphologically distinct from apoptosis.
Francis Ka-Ming, Chan, Joanna, Shisler, Jacqueline G, Bixby, Martin, Felices, Lixin, Zheng, Michael, Appel, Jan, Orenstein, Bernard, Moss, Michael J, Lenardo   +8 more
openaire   +2 more sources

Crystal Structure of Human TWEAK in Complex with the Fab Fragment of a Neutralizing Antibody Reveals Insights into Receptor Binding. [PDF]

, 2013
The tumor necrosis factor-like weak inducer of apoptosis (TWEAK) is a multifunctional cytokine playing a key role in tissue regeneration and remodeling.
Jens Niewoehner, Monika Baehner, Kohnert, Ulrich, Schraeml, Michael, Ulrich Kohnert, Alfred Lammens, Katja Lammens, Lammens, Katja, Karl-Peter Hopfner, Leopold von Proff, Lammens, Alfred, Hopfner, Karl-Peter, Niewoehner, Jens, Michael Schraeml, Baehner, Monika, Proff, Leopold von   +15 more
core   +2 more sources

miR-29a suppresses MCF-7 cell growth by downregulating tumor necrosis factor receptor 1

Tumor Biology, 2017
Tumor necrosis factor receptor 1 is the main receptor mediating many tumor necrosis factor-alpha–induced cellular events. Some studies have shown that tumor necrosis factor receptor 1 promotes tumorigenesis by activating nuclear factor-kappa B signaling ...
Yiling Zhao, Fenghua Yang, Wenyuan Li, Chunyan Xu, Li Li, Lifei Chen, Yancui Liu, Ping Sun   +7 more
doaj   +1 more source

Locally up-regulated lymphotoxin a, not systemic tumor necrosis factor a, is the principle mediator of murine cerebral malaria [PDF]

, 2002
Cerebral malaria (CM) causes death in children and nonimmune adults. TNF-{alpha} has been thought to play a key role in the development of CM. In contrast, the role of the related cyto-kine lymphotoxin {alpha} (LT{alpha}) in CM has been overlooked.
Sanjeet Sawhney, Mynott, T.L., Kaye, PM, De Souza, J Brian, Bickle, Quentin D, Kaye, P.M., Engwerda, C.R., Sawhney, Sanjeet, Engwerda, CR, Tracey L. Mynott, Paul M. Kaye, Christian R. Engwerda, Bickle, Q.D., Sawhney, S, Bickle, QD, Mynott, Tracey L, De Souza, JB, Mynott, TL, Engwerda, Christian R, Sawhney, S., J. Brian De Souza, Quentin D. Bickle, Kaye, Paul M, De Souza, J.B.   +23 more
core   +1 more source