Results 31 to 40 of about 589,523 (288)

Study on the Mechanism of Budesonide in the Treatment of IgA Nephropathy Based on Network Pharmacology [PDF]

Zhongguo quanke yixue, 2023
Background IgA nephropathy (IgAN) is the most common primary glomerulonephritis in China and worldwide, approximately 25%-30% of patients will progress to end-stage renal disease within 20 years after diagnosis.
ZHANG Kang, ZHAO Tingting, ZHANG Bo, GAO Mengqi, LI Yuxi, WANG Shaopeng, ZHAO Wenjing
doaj   +1 more source

Novel anti-tumour necrosis factor receptor-1 (TNFR1) domain antibody prevents pulmonary inflammation in experimental acute lung injury. [PDF]

, 2018
BACKGROUND: Tumour necrosis factor alpha (TNF-α) is a pleiotropic cytokine with both injurious and protective functions, which are thought to diverge at the level of its two cell surface receptors, TNFR1 and TNFR2.

core   +2 more sources

miR-29a suppresses MCF-7 cell growth by downregulating tumor necrosis factor receptor 1

Tumor Biology, 2017
Tumor necrosis factor receptor 1 is the main receptor mediating many tumor necrosis factor-alpha–induced cellular events. Some studies have shown that tumor necrosis factor receptor 1 promotes tumorigenesis by activating nuclear factor-kappa B signaling ...
Yiling Zhao, Fenghua Yang, Wenyuan Li, Chunyan Xu, Li Li, Lifei Chen, Yancui Liu, Ping Sun   +7 more
doaj   +1 more source

Reduction of circulating cholesterol and apolipoprotein levels during sepsis [PDF]

, 1999
Sepsis with multiple organ failure is frequently associated with a substantial decrease of cholesterol levels. This decrease of cholesterol is strongly associated with mortality suggesting a direct relation between inflammatory conditions and altered ...
Alvarez C, Chajek-Shaul T, Engelmann H, Ettinger WH, Ettinger WH, Ettinger WH, Feingold KR, Feingold KR, Flegel WA, Gouni I, Graham A, Greenberg AS, Grove RI, Grunfeld C, Hubsch AP, Ishibashi S, Kipp HA, Moran CS, Netea MG, Pacelli F, Pak YK, Read TE, Semb H, Stopeck AT, Van Gameren MM, Weinstock C, Wilson DE, Yokoyama K   +27 more
core   +1 more source

The Cytoprotective Effects of Tumor Necrosis Factor Are Conveyed Through Tumor Necrosis Factor Receptor–Associated Factor 2 in the Heart [PDF]

Circulation: Heart Failure, 2010
Background— Activation of both type 1 and type 2 tumor necrosis factor (TNF) receptors (TNFR1 and TNFR2) confers cytoprotection in cardiac myocytes. Noting that the scaffolding protein TNF receptor–associated factor 2 (TRAF2) is common to both TNF receptors, we hypothesized that the cytoprotective ...
Jana S, Burchfield, Jian-Wen, Dong, Yasushi, Sakata, Feng, Gao, Huei-Ping, Tzeng, Veli K, Topkara, Mark L, Entman, Natarajan, Sivasubramanian, Douglas L, Mann   +8 more
openaire   +2 more sources

Expression and associations of TRAF1, BMI-1, ALDH1, and Lin28B in oral squamous cell carcinoma

Tumor Biology, 2017
Tumor necrosis factor receptor–associated factor 1, an adaptor protein of tumor necrosis factor 2, is involved in classical nuclear factor (NF)-κB activation and lymphocyte recruitment. However, less is known about the expression and association of tumor
Tian-Fu Wu, Yi-Cun Li, Si-Rui Ma, Bing-Liu, Wen-Feng Zhang, Zhi-Jun Sun   +5 more
doaj   +1 more source

Interactions of Tumor Necrosis Factor–Related Apoptosis-Inducing Ligand (TRAIL) with the Immune System: Implications for Inflammation and Cancer [PDF]

, 2019
Tumor necrosis factor (TNF)-related apoptosis-inducing ligand (TRAIL) is a member of the TNF superfamily. TRAIL has historically been distinct from the Fas ligand and TNFα in terms of selective apoptosis induction in tumor cells and has a nearly non ...
Baukloh, Ann-Kathrin, Beyer, Katharina, Kamphues, Carsten, Kotsch, Katja, Sattler, Arne, Stoyanova, Ani   +5 more
core   +1 more source

Circulating soluble tumor necrosis factor receptors, interleukin‐2 receptors, tumor necrosis factor α, and interleukin‐6 levels in rheumatoid arthritis. [PDF]

Arthritis & Rheumatism, 1993
AbstractObjective. To assess whether circulating concentrations of soluble tumor necrosis factor receptors (sTNFR; p55 and p75), soluble interleukin‐2 receptors (sIL‐2R), tumor necrosis factor α (TNFα), and interleukin‐6 (IL‐6) reflect clinical response and whether changes are dependent on the drug used in rheumatoid arthritis (RA) patients taking ...
Pilar Barrera, Agnes M. Th. Boerbooms, Elly M. Janssen, Robert W. Sauerwein, H. Gallati, Jan Mulder, Theo De Boo, Pierre N. M. Demacker, Levinus B. A. Van De Putte, JOS W. M. Van Der Meer   +9 more
openaire   +1 more source

Role of TNF–TNF Receptor 2 Signal in Regulatory T Cells and Its Therapeutic Implications

Frontiers in Immunology, 2018
Tumor necrosis factor α (TNFα) is a pleiotropic cytokine which signals through TNF receptor 1 (TNFR1) and TNF receptor 2 (TNFR2). Emerging evidence has demonstrated that TNFR1 is ubiquitously expressed on almost all cells, while TNFR2 exhibits a limited ...
Sujuan Yang, Sujuan Yang, Julie Wang, David Douglass Brand, Song Guo Zheng   +4 more
doaj   +1 more source

Osteoprotegerin Contributes to the Metastatic Potential of Cells with a Dysfunctional TSC2 Tumor-Suppressor Gene [PDF]

, 1974
In addition to its effects on bone metabolism, osteoprotegerin (OPG), a soluble member of the tumor necrosis factor family of receptors, promotes smooth muscle cell proliferation and migration and may act as a survival factor for tumor cells.
Steagall, Wendy K., Pacheco-Rodriguez, Gustavo, Glasgow, Connie G., Ikeda, Yoshihiko, Lin, Jing-Ping, Zheng, Gang, Moss, Joel   +6 more
core   +1 more source