Results 11 to 20 of about 589,523 (288)

Lack of Evidence for a Direct Interaction of Progranulin and Tumor Necrosis Factor Receptor-1 and Tumor Necrosis Factor Receptor-2 From Cellular Binding Studies [PDF]

Frontiers in Immunology, 2018
Progranulin (PGRN) is a secreted anti-inflammatory protein which can be processed by neutrophil proteases to various granulins. It has been reported that at least a significant portion of the anti-inflammatory effects of PGRN is due to direct high ...
Isabell Lang, Simone Füllsack, Harald Wajant   +2 more
doaj   +2 more sources

An Autocrine TNFα–Tumor Necrosis Factor Receptor 2 Loop Promotes Epigenetic Effects Inducing Human Treg Stability In Vitro [PDF]

Frontiers in Immunology, 2018
A crucial issue for Treg-based immunotherapy is to maintain a bona fide Treg phenotype as well as suppressive function during and after ex vivo expansion. Several strategies have been applied to harness Treg lineage stability.
Paulo C. M. Urbano, Hans J. P. M. Koenen, Irma Joosten, Xuehui He, Xuehui He   +4 more
doaj   +2 more sources

Essential protective role of tumor necrosis factor receptor 2 in neurodegeneration. [PDF]

Proc Natl Acad Sci U S A, 2016
SignificanceTNF is known to play an important role in various neurodegenerative diseases. However, anti-TNF therapeutics failed in clinical trials of neurodegenerative diseases. This failure is most likely due to antithetic effects of the TNF receptors in the central nervous system, whereby TNFR1 promotes inflammatory degeneration and TNFR2 ...
Dong Y, Fischer R, Naudé PJ, Maier O, Nyakas C, Duffey M, Van der Zee EA, Dekens D, Douwenga W, Herrmann A, Guenzi E, Kontermann RE, Pfizenmaier K, Eisel UL.   +13 more
europepmc   +6 more sources

Expression of Tumor Necrosis Factor Receptor 2 Characterizes TLR9-Driven Formation of Interleukin-10-Producing B Cells [PDF]

Frontiers in Immunology, 2018
B cell-derived interleukin-10 (IL-10) production has been described as a hallmark for regulatory function in B lymphocytes. However, there is an ongoing debate on the origin of IL-10-secreting B cells and lack of specific surface markers has turned into ...
Olga Ticha, Lukas Moos, Harald Wajant, Isabelle Bekeredjian-Ding   +3 more
doaj   +2 more sources

Epigenome-Wide Association Study of Soluble Tumor Necrosis Factor Receptor 2 Levels in the Framingham Heart Study [PDF]

Frontiers in Pharmacology, 2018
Background: Transmembrane tumor necrosis factor (TNF) receptors are involved in inflammatory, apoptotic, and proliferative processes. In the bloodstream, soluble TNF receptor II (sTNFR2) can modify the inflammatory response of immune cells and is ...
Michael M. Mendelson, Michael M. Mendelson, Michael M. Mendelson, Roby Johannes, Chunyu Liu, Chunyu Liu, Tianxiao Huan, Tianxiao Huan, Chen Yao, Chen Yao, Xiao Miao, Joanne M. Murabito, Joanne M. Murabito, Josée Dupuis, Josée Dupuis, Daniel Levy, Daniel Levy, Emelia J. Benjamin, Emelia J. Benjamin, Emelia J. Benjamin, Honghuang Lin, Honghuang Lin   +21 more
doaj   +2 more sources

Tumor necrosis factor receptor 2 as a possible marker of COPD in smokers and ex-smokers [PDF]

International Journal of COPD, 2017
Laura Miranda de Oliveira Caram,1 R Ferrari,1 DL Nogueira,1 MRM Oliveira,2 FV Francisqueti,2 SE Tanni,1 CR Corrêa,2 I Godoy1 1Department of Internal Medicine, 2Department of Pathology, Botucatu Medical School, UNESP – Univ Estadual Paulista,
Caram LMO, Ferrari R, Nogueira DL, Oliveira MRM, Francisqueti FV, Tanni SE, Corrêa CR, Godoy I   +7 more
doaj   +2 more sources

Development of a trispecific fusion protein based on angiotensin-converting enzyme 2, glycoprotein 130, and tumor necrosis factor receptor 2 as a promising therapeutic for COVID-19 [PDF]

Molecular Biomedicine
Despite a substantial reduction in the incidence of coronavirus disease 2019 (COVID-19) infections, severe cases continue to pose a significant clinical burden, particularly among elderly individuals and patients with underlying medical conditions, due ...
Yongfeng Qiao, Yanjun Han, Lu Zhao, Wenjing Gao, Hong Hu, Chao Su, Anqi Zheng, Junqing Sun, Mingxiong Tian, Yarong Wu, Lianmei Bai, Yuping Lei, Jiahao Wu, Weibing Zhang, Pu Han, Xiaoyu Li, Chunbo Dong, Haidong Wang, Zhida Liu, Pengcheng Han   +19 more
doaj   +2 more sources

1′-Acetoxychavicol Acetate Selectively Downregulates Tumor Necrosis Factor Receptor-Associated Factor 2 (TRAF2) Expression

Molecules
1′-Acetoxychavicol acetate (ACA) is a natural compound derived from rhizomes of the Zingiberaceae family that suppresses the nuclear factor κB (NF-κB) signaling pathway; however, the underlying mechanisms remain unclear.
Chihiro Moriwaki, Shingo Takahashi, Nhat Thi Vu, Yasunobu Miyake, Takao Kataoka   +4 more
doaj   +3 more sources

N-terminal and C-terminal domains of calmodulin mediate FADD and TRADD interaction [PDF]

, 2015
FADD (Fas–associated death domain) and TRADD (Tumor Necrosis Factor Receptor 1-associated death domain) proteins are important regulators of cell fate in mammalian cells. They are both involved in death receptors mediated signaling pathways and have been
Balog, Edward M., Castellani, Loriana, Crielesi, Roberta, LALLI, CRISTIANA, MARSILIO, Sonia, Papoff, Giuliana, Ruberti, Giovina, Trivieri, Nadia   +7 more
core   +11 more sources

Features of changes in the expression level of TNFα receptors and the functional response of cell lines upon stimulation with various doses of cytokine

Медицинская иммунология, 2023
TNFa is a pro-inflammatory cytokine that is signaled through type 1 (TNFR1) and type 2 (TNFR2) receptors. TNFR1 normally mediates apoptosis, cell survival, and cytokine secretion, while TNFR2 selectively mediates cell survival and cytokine secretion. But
Yu. A. Lopatnikova, Yu. V. Zhukova, A. A. Alshevskaya, I. A. Obleukhova, F. D. Kireev, I. A. Belomestnova, S. V. Sennikov   +6 more
doaj   +1 more source