Results 61 to 70 of about 29,380,860 (288)

The role of signal transducer and activator of transcription-3 (STAT-3) in ischaemic and pharmacological preconditioning [PDF]

, 2006
Includes bibliographical references (leaves 150-177).Ischemic preconditioning is a protective mechanism whereby repetitive transient ischaemia confer protection against the subsequent prolonged lethal ischaemia that is observed during myocardial ...
Suleman, Naushaad
core   +1 more source

Activated factor X signaling via protease-activated receptor 2 suppresses pro-inflammatory cytokine production from lipopolysaccharide-stimulated myeloid cells

Haematologica, 2014
Vitamin K-dependent proteases generated in response to vascular injury and infection enable fibrin clot formation, but also trigger distinct immuno-regulatory signaling pathways on myeloid cells.
Eimear M. Gleeson, James S. O’Donnell, Emily Hams, Fionnuala Ní Áinle, Bridget-Ann Kenny, Padraic G. Fallon, Roger J.S. Preston   +6 more
doaj   +1 more source

The hepatitis B virus X protein activates nuclear factor of activated T cells (NF-AT) by a cyclosporin A-sensitive pathway. [PDF]

, 1998
The X gene product of the human hepatitis B virus (HBx) is a transcriptional activator of various viral and cellular genes. We recently have determined that the production of tumor necrosis factor-alpha (TNF-alpha) by HBV-infected hepatocytes is ...
Armesilla, Angel, Redondo, Juan Miguel, Lara-Pezzi, Enrique, Juan Miguel Redondo, López-Cabrera, Manuel, Pedro L. Majano, Armesilla, Angel L., Enrique Lara-Pezzi, Angel Luis Armesilla, Majano, Pedro L., Manuel López-Cabrera, Redondo, Juan M.   +11 more
core   +1 more source

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

Lymphotoxins and cytomegalovirus cooperatively induce interferon-beta, establishing host-virus détente [PDF]

, 2001
Tumor necrosis factor (TNF)-related cytokines regulate cell death and survival and provide strong selective pressures for viruses, such as cytomegalovirus (CMV), to evolve counterstrategies in order to persist in immune-competent hosts.
Angulo, A, Ko, M, Britt, William J, Senderowicz, L, Banks, Theresa A, Mira Ko, Chris A Benedict, Benedict, C A, Benedict, Chris A, Ghazal, Peter, Lionel Senderowicz, Ko, Mira, William J Britt, Senderowicz, Lionel, Britt, W J, Carl F Ware, Ware, C F, Banks, T A, Ware, Carl F, Angulo, Ana, Ana Angulo, Theresa A Banks, Peter Ghazal, Ghazal, P   +23 more
core   +1 more source

Liver organoids: modelling complexity in homeostasis and disease

FEBS Letters, EarlyView.
Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley   +1 more source

Soluble tumor necrosis factor receptors in diabetes: risk sensing and receptor-resolved targeting

Endocrine Journal
Diabetes drives a major burden of kidney failure, cardiovascular disease, and premature mortality, yet current clinical markers incompletely capture individual trajectories of organ decline. Soluble tumor necrosis factor receptors 1 and 2 (sTNFR1/2) have
Qi Zhu, Yu Liu, Chen Yang, Tie Li
doaj   +1 more source

Macrophages as a source of tumoricidal activity (tumor-necrotizing factor) [PDF]

, 1980
Macrophage-enriched peritoneal exudate cells from mice infected with Mycobacterium bovis BCG, macrophage-like tumor cells (PU 5-1.8), and peritoneal macrophages propagated in vitro with macrophage growth factor released tumoricidal activity into the ...
Mannel, D N, Moore, R. N., Männel, D. N., Mergenhagen, S E, Mergenhagen, S. E., Moore, R N   +5 more
core   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Pan-cancer analysis of the TRAF family genes and their correlation with prognosis, TME, immune and drug sensitivity

European Journal of Medical Research
Background Tumor necrosis factor receptor-associated factors family genes play a pivotal role in tumorigenesis and metastasis, functioning as adapters or E3 ubiquitin ligases across various signaling pathways.
Bin Yao, Weikang Hu, Yu Chen, Jing Li, Kuirong Jiang, Jin Dou   +5 more
doaj   +1 more source