Results 71 to 80 of about 29,380,860 (288)

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source

Fractional excretion of tumor necrosis factor receptor 1 and 2 in patients with type 2 diabetes and normal renal function

Journal of Diabetes Investigation, 2021
Aims/Introduction Increased concentrations of serum tumor necrosis factor (TNF) receptors (TNFRs; TNFR1 and TNFR2) are positively associated with the urinary albumin‐to‐creatinine ratio (ACR), and negatively associated with the estimated glomerular ...
Tomohito Gohda, Nozomu Kamei, Mitsunobu Kubota, Kanako Tanaka, Yoshinori Yamashita, Hiroko Sakuma, Chiaki Kishida, Eri Adachi, Takeo Koshida, Maki Murakoshi, Shinji Hagiwara, Kazuhiko Funabiki, Seiji Ueda, Yusuke Suzuki   +13 more
doaj   +1 more source

The Ethanol Extracts of Osmanthus fragrans Leaves Ameliorate the Bone Loss via the Inhibition of Osteoclastogenesis in Osteoporosis

Plants, 2023
The aim of this study was to evaluate the anti-osteoporosis effects of Osmanthus fragrans leaf ethanol extract (OFLEE) in bone marrow-derived macrophages (BMM) and animals with osteoporosis.
Yo-Seob Seo, HyangI Lim, Jeong-Yeon Seo, Kyeong-Rok Kang, Do Kyung Kim, Hyun-Hwa Lee, Deuk-Sil Oh, Jae-Sung Kim   +7 more
doaj   +1 more source

Spatial and single‐nuclei transcriptomics reveals idiosyncratic and generic patterns in papillary and anaplastic thyroid cancers

Molecular Oncology, EarlyView.
Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur, Joel Rodrigues Vitória, Manuel Saiselet, Ligia Craciun, Denis Larsimont, Anne Lefort, Frédérick Libert, Carine Maenhaut, Sabine Costagliola, Maxime Tarabichi, Mirian Romitti, Vincent Detours   +11 more
wiley   +1 more source

Elevated CSF levels of TACE activity and soluble TNF receptors in subjects with mild cognitive impairment and patients with Alzheimer's disease [PDF]

, 2011
We recently reported that expression levels of tumor necrosis factor (TNF) receptors, TNFR1 and TNFR2, are significantly changed in the brains and cerebral spinal cerebral fluid (CSF) with Alzheimer's disease (AD).
Blennow, Kaj,, Shen, Yong, Hampel, Harald, Rena Li, Hampel Harald, Prvulovic, David, Yong Shen, Wallin, Anders,, Jiang, Hong, David Prvulovic, Hong Jiang, Wallin, Anders, Kaj Blennow, Wallin Anders, Shen Yong, Anders Wallin, Li, Rena, Blennow Kaj, Jiang Hong, Prvulovic David, Harald Hampel, Blennow, Kaj, Li Rena   +22 more
core   +1 more source

Circulating microRNA signatures of cachexia and cancer in Canis familiaris as a comparative oncology model for human disease

Molecular Oncology, EarlyView.
Circulating microRNAs as biomarkers of cachexia and sex‐specific cancer in senior dogs. In 25 client‐owned dogs, four circulating miRNAs (miR‐15a, miR‐15b, miR‐16, miR‐140) were downregulated in cachexia, with miR‐16 the strongest individual biomarker (AUC = 0.899).
Soon‐Seok Park, Kyongman An, Gyeonghwa Kim, Soo‐Nyun Choi, Hong‐Ki Lee, Keun Hur, Kyu‐Shik Jeong   +6 more
wiley   +1 more source

Identification and functional characterization of a mouse lymphotoxin beta-receptor like protein [PDF]

, 2005
Four different monoclonal rat anti mouse lymphotoxin beta-receptor (mLTbetaR) antibodies were generated in order to study the expression patterns and molecular mechanisms that follow the activation of this receptor which belongs to the TNFR superfamily ...
Seegers, Silvia
core   +1 more source

Preoperative circulating tumor cells integrated with imaging analysis for prognostic evaluation in head and neck squamous cell carcinoma

Molecular Oncology, EarlyView.
Detecting circulating tumor cells (CTCs) in blood before surgery may help predict outcomes in patients with head and neck squamous cell carcinoma (HNSCC). Here, we show when combined with tumor size and lymph node involvement from routine imaging, CTC status identifies high‐risk patients with poorer survival—offering a simple, minimally invasive tool ...
Susanne Flach, Gizem Abaci, Tom Huberty, Axel Lechner, Lukas Käsmann, Jens Ricke, Sophia Stöcklein, Martin Canis, Philipp Baumeister, Marianna Alunni‐Fabbroni   +9 more
wiley   +1 more source

1′-Acetoxychavicol Acetate Selectively Downregulates Tumor Necrosis Factor Receptor-Associated Factor 2 (TRAF2) Expression

Molecules
1′-Acetoxychavicol acetate (ACA) is a natural compound derived from rhizomes of the Zingiberaceae family that suppresses the nuclear factor κB (NF-κB) signaling pathway; however, the underlying mechanisms remain unclear.
Chihiro Moriwaki, Shingo Takahashi, Nhat Thi Vu, Yasunobu Miyake, Takao Kataoka   +4 more
doaj   +1 more source

Moving nuclear receptor Nur77 to damaged mitochondria for clearance by mitophagy

Molecular & Cellular Oncology, 2018
Selective clearance of damaged mitochondria can reverse pathological status in chronic inflammatory diseases. We recently identified a critical role of nuclear receptor Nur77 and celastrol in priming inflamed mitochondria for autophagy through its ...
Mengjie Hu, Gulimiran Alitongbieke, Ying Su, Hu Zhou, Xiao-kun Zhang   +4 more
doaj   +1 more source