Results 61 to 70 of about 29,410 (210)

Anti-TNFR2 Antibody-Conjugated PLGA Nanoparticles for Targeted Delivery of Adriamycin in Mouse Colon Cancer

Research
High levels of tumor necrosis factor receptor type II (TNFR2) are preferentially expressed by immunosuppressive CD4+Foxp3+ regulatory T cells (Tregs), especially those present in the tumor microenvironment, as initially reported by us.
Ping Li, Yang Yang, Yifei Wang, Jingbin Zheng, Fengyang Chen, Mengmeng Jiang, Chon-kit Chou, Weihong Cong, Zongjin Li, Xin Chen   +9 more
doaj   +1 more source

Development of a Human 3D Immune‐Competent Neurovascular Model Enabling Time‐Resolved Monitoring of Neuroinflammatory Dynamics and Neuroimmune Interactions

Advanced Science, EarlyView.
Neuroinflammation alters blood–brain barrier integrity and contributes to neurological disorders, yet existing models lack human immune complexity. This study presents a 3D, immune‐responsive platform that reconstructs key neurovascular components and enables real‐time monitoring.
Pavlo Gordiichuk, Jing Bai, Olurotimi A. Bolonduro, Andrew M. Silverman, Robert Madison Green, Jason H. Lasser, Paul W. Fleming, Lishomwa C. Ndhlovu, James F. Saunders, Dmitry Shvartsman   +9 more
wiley   +1 more source

Tumour necrosis factor‐α‐induced loss of intestinal barrier function requires TNFR1 and TNFR2 signalling in a mouse model of total parenteral nutrition [PDF]

, 2013
Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/99095/1/jphysiol.2013.253518 ...
Feng, Yongjia, Teitelbaum, Daniel H.
core   +1 more source

Interleukin 6 Present in Inflammatory Ascites from Advanced Epithelial Ovarian Cancer Patients Promotes Tumor Necrosis Factor Receptor 2-Expressing Regulatory T Cells

Frontiers in Immunology, 2017
BackgroundEpithelial ovarian cancer (EOC) remains a highly lethal gynecological malignancy. Ascites, an accumulation of peritoneal fluid present in one-third of patients at presentation, is linked to poor prognosis.
Nirmala Chandralega Kampan, Nirmala Chandralega Kampan, Nirmala Chandralega Kampan, Mutsa Tatenda Madondo, Orla M. McNally, Andrew N. Stephens, Andrew N. Stephens, Andrew N. Stephens, Michael A. Quinn, Magdalena Plebanski, Magdalena Plebanski   +10 more
doaj   +1 more source

Cytokine Pathways Driving Diverse Tissue Pathologies in Rheumatoid Arthritis

Arthritis &Rheumatology, EarlyView.
Rheumatoid arthritis (RA) is a complex systemic disorder characterized primarily by articular inflammation and destruction with associated functional loss and reduced quality of life. RA is also associated with extra‐articular disease, such as that of the lung, with potentially devastating clinical consequences. The critical importance of comorbidities,
Aurelie Najm, Lyn D. Ferguson, Iain B. McInnes   +2 more
wiley   +1 more source

Elevated CSF levels of TACE activity and soluble TNF receptors in subjects with mild cognitive impairment and patients with Alzheimer's disease [PDF]

, 2011
We recently reported that expression levels of tumor necrosis factor (TNF) receptors, TNFR1 and TNFR2, are significantly changed in the brains and cerebral spinal cerebral fluid (CSF) with Alzheimer's disease (AD).
Hong Jiang, Harald Hampel, David Prvulovic, Anders Wallin, Kaj Blennow, Rena Li, Yong Shen   +6 more
core   +2 more sources

The effect of non‐surgical periodontal treatment on progranulin levels

Journal of Periodontology, EarlyView.
Abstract Background The aim of this study was to study the effect of non‐surgical periodontal therapy (NSPT) on gingival crevicular fluid (GCF) and serum progranulin (PGRN) levels in the early healing phases. Methods The study included periodontitis (test) (n = 24) and periodontal health (control) (n = 24) groups.
Aysegul Sari, Pasquale Santamaria, Luigi Nibali   +2 more
wiley   +1 more source

Central but not systemic administration of XPro1595 is therapeutic following moderate spinal cord injury in mice [PDF]

, 2014
BACKGROUND: Glial cell activation and overproduction of inflammatory mediators in the central nervous system (CNS) have been implicated in acute traumatic injuries to the CNS, including spinal cord injury (SCI).
Bethea, John R, Bracchi-Ricard, Valerie, Ellman, Ditte G, Jain, Anjana, Lambertsen, Kate L, Lyck, Lise, Novrup, Hans G, Pearse, Damien D, Ricard, Jerome, Runko, Erik, Szymkowski, David E, Yli-Karjanmaa, Minna   +11 more
core   +1 more source

The Immunosuppressive Effect of TNFR2 Expression in the Colorectal Cancer Microenvironment

Biomedicines, 2023
Colorectal cancer (CRC) represents one of the most common causes of death among cancers worldwide. Its incidence has been increasing among the young population.
Nurul Hakimah Mohd Salim, Ali Mussa, Naveed Ahmed, Suhana Ahmad, Chan Yean Yean, Rosline Hassan, Vuk Uskoković, Rohimah Mohamud, Nur Asyilla Che Jalil   +8 more
doaj   +1 more source

Inflammation, Immunity, and Cardiovascular Diseases

Med Research, EarlyView.
Cardiovascular stress signals (e.g., hemodynamic shear, oxidized lipids, and ischemia) act on endothelial and immune cells to activate and amplify inflammation through NF‐κB, the NLRP3 inflammasome, and JAK/STAT signaling, inducing proinflammatory cytokines/chemokines (IL‐6, IL‐1β, TNF‐α, and CCL2) and self‐amplifying circuits; clinically, inflammatory
Dezhi Guo, Yan Liao, Rui Zhao, Zhaoyu Li, Kaikai Wang, Haoling Zhang, Pingxin Sun, Yadong Guo, Wangzheqi Zhang   +8 more
wiley   +1 more source