Results 81 to 90 of about 29,410 (210)
Phase 1 study of balinatunfib, an oral inhibitor of TNFR1 signal in mild‐to‐moderate psoriasis
Journal of the European Academy of Dermatology and Venereology, EarlyView.Balinatunfib is the first oral, small molecule selective inhibitor of TNFR1 signaling. The results of this study indicate that balinatunfib treatment was tolerable with no serious or severe adverse events in patients with mild‐to‐moderate psoriasis and showed clinical responses.
Nassr Nassr +10 more
wiley +1 more source
Role of TNF-alpha during central sensitization in preclinical studies [PDF]
, 2011 Tumor necrosis factor-alpha (TNF-alpha) is a principal mediator in pro-inflammatory processes that involve necrosis, apoptosis and proliferation. Experimental and clinical evidence demonstrate that peripheral nerve injury results in activation and ...
Pablo Andrade +5 more
core +1 more source
Modulation of Regulatory T Cell Activity by TNF Receptor Type II-Targeting Pharmacological Agents
Frontiers in Immunology, 2018 There is now compelling evidence that tumor necrosis factor (TNF)–TNF receptor type II (TNFR2) interaction plays a decisive role in the activation, expansion, and phenotypical stability of suppressive CD4+Foxp3+ regulatory T cells (Tregs).
Huimin Zou +4 more
doaj +1 more source
BMC Molecular and Cell Biology, 2020 Background Low concentrations of tumor necrosis factor-alpha (TNF-α) and its receptor TNFR2 are both reported to promote osteogenic differentiation of osteoblast precursor cells.
Yu Zhang +5 more
doaj +1 more source
Veterinary and Comparative Oncology, EarlyView.ABSTRACT Spontaneously occurring primary canine pulmonary adenocarcinoma (cPAC) exhibits clinicopathological and molecular similarities to never‐smoker human lung cancers. Shared genomic alterations, including point mutations, indel mutations and copy number changes particularly in HER2 signalling, are significant therapeutic targets, especially for ...
Sharadha Sakthikumar +10 more
wiley +1 more source
Gene Expression Meta-Analysis identifies Cytokine Pathways and 5q Aberrations involved in Metastasis of ERBB2 Amplified and Basal Breast Cancer [PDF]
, 2013 Background Breast tumors have been described by molecular subtypes characterized by pervasively different gene expression profiles. The subtypes are associated with different clinical parameters and origin of precursor cells.
Burton, Mark +3 more
core +2 more sources
American Journal of Hematology, Volume 101, Issue 6, Page 1388-1397, June 2026.ABSTRACT Soluble tumor necrosis factor receptor 2 (sTNFR2) is a member of the TNF superfamily whose normal bodily distribution is largely limited to low level expression on lymphoid cells. It has emerged as an important inducible receptor that activates a signaling pathway for cancer growth.
Arushi Khurana +14 more
wiley +1 more source
Activation of TNFR2 sensitizes macrophages for TNFR1-mediated necroptosis
Cell Death & Disease, 2016 AbstractMacrophages express TNFR1 as well as TNFR2 and are also major producers of tumor necrosis factor (TNF), especially upon contact with pathogen-associated molecular patterns. Consequently, TNF not only acts as a macrophage-derived effector molecule but also regulates the activity and viability of macrophages.
Siegmund, Daniela +3 more
openaire +2 more sources
Frontiers in Immunology, 2018 Tumor necrosis factor (TNF) is a pleiotropic cytokine that has both pro-inflammatory and anti-inflammatory functions. The biological functions of TNF are mediated by two receptors, TNF receptor type I (TNFR1) and TNF receptor type II (TNFR2).
Lin-Lin Ye +4 more
doaj +1 more source
Acta Psychiatrica Scandinavica, Volume 153, Issue 5, Page 477-489, May 2026.ABSTRACT Background and Hypothesis Deficits in processing speed (PS) and psychomotor speed (PMS) are core cognitive impairments in schizophrenia spectrum disorders, including first‐episode psychosis (FEP). Neuroinflammation has been proposed as a potential contributor to these deficits.
Ángel Yorca‐Ruiz +8 more
wiley +1 more source