Diabetic kidney disease, biomarkers, and finerenone
Diabetes, Obesity and Metabolism, Volume 28, Issue 4, Page 2582-2593, April 2026.Abstract Diabetic kidney disease (DKD), the leading cause of kidney failure worldwide, is associated with an increased risk of cardiovascular disease (CVD). A complex pathobiology involving hemodynamic, metabolic, and immune dysregulation promotes inflammatory and fibrotic pathways that contribute to kidney disease progression and CVD in individuals ...
Ashish Verma, Ashish Upadhyay
wiley +1 more source
The characterization of tumor necrosis factor alpha (TNF-α), its role in cancerogenesis and cardiovascular system diseases and possibilities of using this cytokine as a molecular marker [PDF]
, 2017 The inflammatory process is directly associated with secretion of cytokines, e.g. tumor necrosis factor alpha (TNF-α). This molecule is one of the 22 proteins which belong to TNF family and is secreted mainly by: macrophages, monocytes, T lymphocyte and ...
Bednarczyk, Martyna +2 more
core +2 more sources
Степень тяжести сахарного диабета 2 типа и генетический полиморфизм +1663 +G/A TNFR2 [PDF]
, 2011 Рассматривается влияние полиморфизма гена рецептора фактора некроза опухоли 2-го типа (+1663 GА TNFR2) на степень тяжести сахарного диабета 2 типа. Материалом для исследования послужили образцы ДНК (115 больных СД2 и 300 здоровых индивидов контрольной ...
Белоусова, О. Н. +1 more
core
Prioritizing genes responsible for host resistance to influenza using network approaches [PDF]
, 2013 published_or_final_versio
Bao, S +8 more
core +2 more sources
Frontiers in Immunology, 2018 There is now compelling evidence that TNF receptor type II (TNFR2) is predominantly expressed on CD4+Foxp3+ regulatory T cells (Tregs) and myeloid-derived suppressor cells (MDSCs), and plays a major role in the expansion and function of Tregs and MDSCs ...
Faraz Shaikh +4 more
doaj +1 more source
The role of IL-17 in inflammatory hyperalgesia
, 2011 Rheumatoid arthritis (RA) is a chronic autoimmune disease that affects up to 1% of the population. The importance of tumour necrosis factor (TNF) in RA has been established and anti-TNF biologics have proved to be highly effective in reducing ...
McNamee, Kay Edwina, McNamee, Kay Edwina
core +1 more source
Glucocorticoid-induced microRNA-511 protects against TNF by down-regulating TNFR1 [PDF]
, 2015 TNF is a central actor during inflammation and a well-recognized drug target for inflammatory diseases. We found that the mouse strain SPRET/Ei, known for extreme and dominant resistance against TNF-induced shock, displays weak expression of TNF receptor
Dejager, Lien +11 more
core +1 more source
Tnfa Signaling Through Tnfr2 Protects Skin Against Oxidative Stress–Induced Inflammation
PLoS Biology, 2014 TNFα overexpression has been associated with several chronic inflammatory diseases, including psoriasis, lichen planus, rheumatoid arthritis, and inflammatory bowel disease. Paradoxically, numerous studies have reported new-onset psoriasis and lichen planus following TNFα antagonist therapy.
Candel, Sergio +13 more
openaire +7 more sources
TNFR1 and TNFR2 Expression and Induction on Human Treg Cells from Type 1 Diabetic Subjects
Antibodies, 2015 Several autoimmune diseases are marked by a deficiency of soluble tumor necrosis factor (TNF). The TNF deficiency is caused in at least one autoimmune disease, multiple sclerosis, by an overabundance of TNF receptor 1 (TNFR1).
Melanie Heinrich +9 more
doaj +1 more source
Regulatory T cell induction by mesenchymal stem cells depends on the expression of TNFR2 by T cells
Stem Cell Research & Therapy, 2020 Mesenchymal stem/stromal cells can modulate the effector immune cells especially T lymphocytes. Due to this important feature, they can regulate the development of a variety of disorders including inflammatory and autoimmune disorders, cancers, and ...
Sina Naserian +3 more
doaj +1 more source