Results 111 to 120 of about 29,410 (210)

Phenotypic screening reveals TNFR2 as a promising target for cancer immunotherapy [PDF]

, 2016
© 2015. Oncotarget. Antibodies that target cell-surface molecules on T cells can enhance anti-tumor immune responses, resulting in sustained immune-mediated control of cancer. We set out to find new cancer immunotherapy targets by phenotypic screening on
Allison, Amstutz, Becker, Bonnell, Brodt, Byrne, Davis, Edinger, Ettlin, Freeth, Fu, Fujiwara, Gandara, Goldstein, Goukassian, Haanen, Hollingsworth, Jiang, Jonuleit, Jure-Kunkel, Lazo, Lipsky, Lutzky, Maio, Minato, O'Day, O'sullivan, Ohashi, Oppenheim, Oppenheim, Oppenheim, Palladino, Pardoll, Plebanski, Pluckthun, Pluckthun, Pluckthun, Quezada, Ravetch, Sakaguchi, Sakaguchi, Scheurich, Schreiber, Semenzato, Smith, Teh, Thomas, Toda, Watts, Watts, Wilkinson, Wolchok, Wolf, Zhang, Zhou   +54 more
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Creation of mouse TNFR2-selective agonistic TNF mutants using a phage display technique

Biochemistry and Biophysics Reports, 2016
Tumor necrosis factor-α (TNF), which is an immuno-modulatory cytokine, has been suggested to cause inflammatory responses as well as protection against tissue dysfunction by binding two types of TNF receptor (TNFR1/TNFR2).
Daisuke Ando, Daisuke Ando, Daisuke Ando, Masaki Inoue, Masaki Inoue, Masaki Inoue, Haruhiko Kamada, Haruhiko Kamada, Haruhiko Kamada, Shintaro Taki, Shintaro Taki, Takeshi Furuya, Takeshi Furuya, Yasuhiro Abe, Kazuya Nagano, Kazuya Nagano, Kazuya Nagano, Yasuo Tsutsumi, Yasuo Tsutsumi, Yasuo Tsutsumi, Shin-ichi Tsunoda, Shin-ichi Tsunoda, Shin-ichi Tsunoda, Shin-ichi Tsunoda, Shin-ichi Tsunoda   +24 more
doaj   +1 more source

Hyperexpression of tumor necrosis factor receptor 2 inhibits differentiation of myeloid‐derived suppressor cells by instigating apolarity during ageing

MedComm
During the ageing process, TNF‐α can promote the expansion of myeloid‐derived suppressor cells (MDSCs). However, it remains unclear which receptor(s) of TNF‐α are involved in and how they modulate this process.
Ming Wang, Yijie Han, Xiaohan Yao, Xixi Duan, Jiajia Wan, Xiaohan Lou, Yan Yan, Peiguo Zheng, Fazhan Wang, Linyu Zhu, Chen Ni, Zhenzhen Pan, Zihao Wang, Lin Chen, Zhaoqing Wang, Zhihai Qin   +15 more
doaj   +1 more source

Homogeneous Expansion of Human T-Regulatory Cells Via Tumor Necrosis Factor Receptor 2 [PDF]

, 2014
T-regulatory cells (Tregs) are a rare lymphocyte subtype that shows promise for treating infectious disease, allergy, graft-versus-host disease, autoimmunity, and asthma.
Faustman, Denise L., Mera, Toshiyuki, Okubo, Yoshiaki, Wang, Limei   +3 more
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TNF-α and neuropathic pain - a review [PDF]

, 2010
Tumor necrosis factor alpha (TNF-α) was discovered more than a century ago, and its known roles have extended from within the immune system to include a neuro-inflammatory domain in the nervous system.
Lawrence Leung, Catherine M Cahill
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Lactylation-driven TNFR2 expression in regulatory T cells promotes the progression of malignant pleural effusion

Journal for ImmunoTherapy of Cancer
Background Although tumor necrosis factor receptor 2 (TNFR2) has been recognized as an attractive next-generation candidate target for cancer immunotherapy, the factors that regulate the gene expression and their mechanistic effects on tumor-infiltrating
Yao Liu, Qiong Zhou, Siyu Zhang, Wenbei Peng, Haolei Wang, Xuan Xiang, Linlin Ye, Xiaoshan Wei, Zihao Wang, Qianqian Xue   +9 more
doaj   +1 more source

TNFR2 blockade promotes antitumoral immune response in PDAC by targeting activated Treg and reducing T cell exhaustion

Journal for ImmunoTherapy of Cancer
Background Pancreatic ductal adenocarcinoma (PDAC) is one of the most aggressive cancers, highly resistant to standard chemotherapy and immunotherapy.
Eliane Piaggio, Allan Thiolat, Anais Debesset, Caroline Pilon, Benoît Laurent Salomon, José Laurent Cohen, Sylvain Baulande, Sylvain Meunier, Orianne Cuelenaere-Bonizec, Wilfrid Richer, Claire Houppe, Matteo Ponzo, Jeanne Magnan, Jonathan Caron, Pamela Caudana, Jimena Tosello Boari, Nhu Han To, Ilaria Cascone   +17 more
doaj   +1 more source

Entwicklung und Charakterisierung von TNFR2-spezifischen Agonisten

, 2017
Liganden und Rezeptoren des Körpers spielen eine multifaktorielle Rolle in der Regulierung zellulärer Prozesse des Körpers. Der Tumornekrosefaktor (TNF), ein proinflammatorisches Zytokin, bindet natürlicherweise an zwei Rezeptoren, den TNF-Rezeptor 1 (TNFR1) oder den TNFR-Rezeptor 2 (TNFR2) und kann durch Aktivierung vielfältiger Signalwege ...
openaire   +3 more sources

The association between TNF-receptors (TNFR1 and TNFR2) and mortality as well as kidney function decline in patients with chronic kidney disease

Upsala Journal of Medical Sciences
Background: Higher circulating levels of tumor necrosis factor (TNF) alpha receptors 1 (TNFR1) and 2 (TNFR2) are associated with increased long-term mortality and impaired kidney function.
Per Wändell, Tobias Feldreich, Anders Larsson, Philip A. Kalra, Johan Ärnlöv, Toralph Ruge, Axel C. Carlsson   +6 more
doaj   +1 more source

The effects of tumor necrosis factor and interleukin 1 on osseous and soft tissue wound healing [PDF]

, 2002
Thesis (M.S.D.)--Boston University, Henry M. Goldman School of Dental Medicine, 2002 (Endodontics).Includes bibliography (leaves 63-68).The role of inflammatory mediators in surgical repair has not been delineated.
Gillen, Thomas
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