Results 91 to 100 of about 29,410 (210)
A TRAF2 binding independent region of TNFR2 is responsible for TRAF2 depletion and enhancement of cytotoxicity driven by TNFR1 [PDF]
, 2014 Work at the authors laboratory was supported by Grant SAF2009-07227 from the Spanish Ministry of Science and Technology (MICINN) and by Grant IB09- 066 from the Plan Regional de Ciencia y Tecnología del Principado de Asturias (PCTI). LCH was recipient of
Artime Pérez, Noelia +8 more
core
Frontiers in Immunology, 2018 B cell-derived interleukin-10 (IL-10) production has been described as a hallmark for regulatory function in B lymphocytes. However, there is an ongoing debate on the origin of IL-10-secreting B cells and lack of specific surface markers has turned into ...
Olga Ticha +3 more
doaj +1 more source
FASEB BioAdvances, 2020 Clear cell renal cell carcinoma (ccRCC) contains cancer stem‐like cells (CSCs) that express CD133 (ccRCC‐CD133+). CSCs are rarely in cell cycle and, as nonproliferating cells, resist most chemotherapeutic agents.
John R. Bradley +5 more
doaj +1 more source
Functional Role of COP1 Gene in Hepatocellular Carcinoma Lipid Metabolism and Stemness
Genes to Cells, Volume 31, Issue 3, May 2026.COP1 promotes HCC lipid metabolism and stemness via the functional interaction with AKR1D1 and TMEM65 genes, respectively, indicating its potential as a therapeutic target for treating primary HCC and preventing metastasis and/or recurrence. ABSTRACT We have previously defined the constitutive photomorphogenic protein 1 (COP1) gene as a therapeutic ...
Eun‐Hye Jeon +8 more
wiley +1 more source
Peptides identify multiple hotspots within the ligand binding domain of the TNF receptor 2 [PDF]
, 2003 Background Hotspots are defined as the minimal functional domains involved in protein:protein interactions and sufficient to induce a biological response.
Lennick Michael +7 more
core +1 more source
Role of TNF–TNF Receptor 2 Signal in Regulatory T Cells and Its Therapeutic Implications
Frontiers in Immunology, 2018 Tumor necrosis factor α (TNFα) is a pleiotropic cytokine which signals through TNF receptor 1 (TNFR1) and TNF receptor 2 (TNFR2). Emerging evidence has demonstrated that TNFR1 is ubiquitously expressed on almost all cells, while TNFR2 exhibits a limited ...
Sujuan Yang +4 more
doaj +1 more source
Advanced Healthcare Materials, Volume 15, Issue 16, 24 April 2026.This study evaluates 3D‐printed recombinant spider silk hydrogel eADF4(C16)‐RGD in a rat AV loop model for tissue engineering. Constructs with T17b endothelial progenitor cells showed enhanced vascularization and biodegradation. Results highlight the importance of scaffold design and cellular integration in improving vascular density and overall ...
Claire M. Weinhold +9 more
wiley +1 more source
β-Adrenoceptor activation depresses brain inflammation and is neuroprotective in lipopolysaccharide-induced sensitization to oxygen-glucose deprivation in organotypic hippocampal slices [PDF]
, 2010 Background Inflammation acting in synergy with brain ischemia aggravates perinatal ischemic brain damage. The sensitizing effect of pro-inflammatory exposure prior to hypoxia is dependent on signaling by TNF-α through TNF receptor (TNFR) 1 ...
Tina Markus +5 more
core +2 more sources
Aging Cell, Volume 25, Issue 4, April 2026.Single‐cell profiling of PBMCs from centenarians, their offspring, and elderly controls revealed distinct myeloid‐to‐effector immune cell communication programs. General aging was characterized by SASP‐enriched signaling associated with immunosenescence, whereas healthy aging showed positive immune regulatory signaling associated with enhanced ...
Liwei Qiu +7 more
wiley +1 more source
BMC Veterinary Research, 2019 Background Refractory diseases, including bacterial infections, are causing huge economic losses in dairy farming. Despite efforts to prevent and treat those diseases in cattle, including the use of antimicrobials, it is not well controlled in the field.
Sotaro Fujisawa +7 more
doaj +1 more source