A TRAF2 binding independent region of TNFR2 is responsibl for TRAF2 depletion and enhancement of cytotoxicity driven b TNFR1 [PDF]
, 2014 Tumor Necrosis Factor (TNF) interacts with two receptors known as TNFR1 and TNFR2. TNFR1 activation may result in either cell proliferation or cell death.
Cabal-Hierro, Lucía +8 more
core
Myosin light chain kinase expression induced via tumor necrosis factor receptor 2 signaling in the epithelial cells regulates the development of colitis-associated carcinogenesis. [PDF]
PLoS ONE, 2014 It has been suggested that prolonged inflammatory bowel diseases (IBD) may lead to colitis-associated carcinogenesis (CAC). We previously observed that the NF-κB activation in colonic epithelial cells is associated with increased tumor necrosis factor ...
Masahiro Suzuki +13 more
doaj +1 more source
TNF Pathway‐Mediated Tolerogenic T‐Cell Trajectory Driven by Allergen Immunotherapy
Allergy, EarlyView.The study shows that AIT re‐establishes local immune equilibrium by restoring Th17/Treg balance, while circulating Th17 cells remain functionally impaired. The transition from pro‐inflammatory Th17 to regulatory T cell states during AIT identifies Tr17 cells as an intermediate cell population.
Helen S. Charles +20 more
wiley +1 more source
Tumor necrosis factor-alpha modulates survival, proliferation, and neuronal differentiation in neonatal subventricular zone cell cultures [PDF]
, 2008 Tumor necrosis factor (TNF)- has been reported to modulate brain injury, but remarkably, little is known about its effects on neurogenesis. We report that TNF- strongly influences survival, proliferation, and neuronal differentiation in cultured ...
Agasse, Fabienne +5 more
core +2 more sources
Redox Experimental MedicineObjective: Malaria remains an important life-threatening disease that provokes a complex immune response, marked by an initial immune boost followed by long-term suppression, warranting further study.
Oleksii Skorokhod +5 more
doaj +1 more source
ADAM17 and its proteolytic targets in disease pathogenesis
The FEBS Journal, EarlyView.ADAM17 as a multifunctional sheddase with contrasting roles across inflammatory, metabolic, cardiovascular, and neoplastic diseases. Through regulated activation by iRhom, iTAP/FRMD8, and tetraspanins, ADAM17 cleaves diverse membrane ligands and receptors, thereby promoting inflammation, fibrosis, obesity, insulin resistance, and tumor progression ...
Abdulbasit Amin, Marina Badenes
wiley +1 more source
In Vivo Systems Analysis Identifies Spatial and Temporal Aspects of the Modulation of TNF-α-Induced Apoptosis and Proliferation by MAPKs [PDF]
, 2010 Cellular responses to external stimuli depend on dynamic features of multipathway network signaling; thus, cell behavior is influenced in a complex manner by the environment and by intrinsic properties.
Cavaliere, Kimberly R. +5 more
core +1 more source
The FASEB Journal, 2009 In the AOM/DSS model of inflammation‐associated colon cancer, intestinal epithelial cell‐specific (IEC)‐SOCS3 deletion increases tumor load, enhances STAT3 and NF¿B activation, and up‐regulates TNFR2. TNFR2 mediates proliferation and reduces apoptosis of IEC, and is increased in inflammatory bowel diseases and ...
Kathryn Elizabeth Hamilton +3 more
openaire +1 more source
Biogenesis of TNF‐α‐insights into proteostasis and inflammation
The FEBS Journal, EarlyView.TNF‐α biogenesis, trafficking, and signalling are tightly and reciprocally coupled to cellular proteostasis systems, including ER chaperones and endoplasmic reticulum‐associated degradation. This bidirectional crosstalk determines whether TNF‐α responses are adaptive or proteotoxic.
Bailasan Haidar +3 more
wiley +1 more source
Biomechanical strain regulates TNFR2 but not TNFR1 in TMJ cells [PDF]
Journal of Biomechanics, 2007 We sought to examine whether cyclic tensile strain (CTS) regulates the gene expression of tumor necrosis factor (TNF)-alpha, its receptors TNFR1 and TNFR2, and inducible nitric oxide synthase (iNOS) under inflammatory conditions, and whether these effects of CTS are sustained.
James, Deschner +5 more
openaire +2 more sources