Results 1 to 10 of about 1,332,792 (304)

Nifuroxazide suppresses PD-L1 expression and enhances the efficacy of radiotherapy in hepatocellular carcinoma

eLife
Radiation therapy is a primary treatment for hepatocellular carcinoma (HCC), but its effectiveness can be diminished by various factors. The over-expression of PD-L1 has been identified as a critical reason for radiotherapy resistance.
Tiesuo Zhao, Pengkun Wei, Congli Zhang, Shijie Zhou, Lirui Liang, Shuoshuo Guo, Zhinan Yin, Sichang Cheng, Zerui Gan, Yuanling Xia, Yongxi Zhang, Sheng Guo, Jiateng Zhong, Zishan Yang, Fei Tu, Qianqing Wang, Jin Bai, Feng Ren, Zhiwei Feng, Huijie Jia   +19 more
doaj   +1 more source

Combination therapy with Nifuroxazide and Lenvatinib exerts superior anti-hepatocellular carcinoma effect by enhancing the anti-tumor immune response

Frontiers in Oncology
BackgroundLenvatinib is a first-line multi-target tyrosine kinase inhibitor for hepatocellular carcinoma (HCC) that exerts anti-angiogenic effects by blocking VEGF signaling.
Jing Yang, Jiaxin Geng, Jiaxin Geng, Yue Yin, Yue Yin, Kangle Wang, Kangle Wang, Leyao Tian, Leyao Tian, Jingyi Wang, Jingyi Wang, Huijie Jia, Huijie Jia, Lei Wang, Yongxi Zhang, Tiesuo Zhao, Tiesuo Zhao   +16 more
doaj   +1 more source

Nephrotoxicity of checkpoint inhibitors; a current challenge [PDF]

Journal of Nephropharmacology
Immune checkpoint inhibitors work by blocking the "checkpoint" mechanism that tumors use to hide from the immune system, therefore also weakening the immune system.
Samaneh Zandifar, Mahshid Imankhan, Padideh Daneii, Ali Azarpey, Leila Alem   +4 more
doaj   +1 more source

Adverse effects of immune checkpoint inhibitor therapies on right ventricular function and pulmonary arterial dilatation

Pulmonary Circulation, 2021
Immunologic risk factors contribute to endothelial dysfunction and development of pulmonary vascular disease. Immune checkpoint inhibitors, used as immunotherapies for malignancies, have a wide range of reported immune-related adverse events.
Ruben Mylvaganam, Ryan Avery, Isaac Goldberg, Courtney Makowski, Ravi Kalhan, Victoria Villaflor, Michael J. Cuttica   +6 more
doaj   +1 more source

Reprogramming the tumor microenvironment to overcome immunotherapy resistance in pancreatic cancer

Frontiers in Immunology
BackgroundPancreatic ductal adenocarcinoma (PDAC) exhibits profound resistance to immunotherapy due to its highly immunosuppressive tumor microenvironment (TME).ObjectiveThis review aims to elucidate the key mechanisms of TME-mediated immune evasion in ...
Xianfeng Hui, Xianfeng Hui, Xianfeng Hui, Xiaowei Tian, Shihuan Ding, Shihuan Ding, Shihuan Ding, Aiping Sun, Tiesuo Zhao, Tiesuo Zhao, Hui Wang, Hui Wang   +11 more
doaj   +1 more source

MiR-362-3p inhibits the proliferation, migration and EMT of gastric cancer cells by regulating the DEP-1/ERK signaling pathway

Scientific Reports
MicroRNAs (miRNAs) play a very important role in the development of gastric cancer (GC). MiR-362-3p participates in the formation and progression of various cancers. However, the role and clinical value of miR-362-3p in GC remain unclear.
Fei Tu, Zhiyuan Li, Lina Yao, Fengyuan He, Yiqing Jia, Lingzhu Wang, Tiesuo Zhao, Sheng Guo, Yan Jin, Zhijun Yang   +9 more
doaj   +1 more source

The APC/C subunit APC7 exerts antiviral effects by targeting the adaptor protein MAVS

Frontiers in Immunology
The innate immune response is the first line of host defense against viral infection. RNA virus infection triggers activation of retinoic acid-inducible gene-I (RIG-I)-mitochondrial antiviral signaling protein (MAVS) signaling pathway, resulting in the ...
Rui Su, Aiping Sun, Aiping Sun, Yifan Niu, Tiesuo Zhao, Tiesuo Zhao, Hui Wang   +6 more
doaj   +1 more source

Regulation of Intrinsic Functions of PD-L1 by Post-Translational Modification in Tumors

Frontiers in Oncology, 2022
Tumor cells are eliminated by the immune system, including T lymphocytes and natural killer cells; however, many types of tumor cells acquire the immune tolerance by inhibiting T-cell activation and functions via immune checkpoint molecules ...
Naoe Taira Nihira, Naoe Taira Nihira, Yoshio Miki   +2 more
doaj   +1 more source

MiR-30a-5p activates the AKT signalling pathway by targeting PHTF2 to inhibit migration and EMT of gastric cancer

Scientific Reports
MicroRNAs (miRNAs) play a very important role in the development of gastric cancer (GC). MiR-30a-5p Participates in the formation and progression of various cancers. However, the role and clinical value of miR-30a-5p in GC remain unclear.
Fei Tu, Fengyuan He, Zhiyuan Li, Yiqing Jia, Lingzhu Wang, Tiesuo Zhao, Sheng Guo, Yan Jin, Zhijun Yang   +8 more
doaj   +1 more source

Advances and prospects of mucosal vaccination in the prevention and control of avian influenza

Frontiers in Immunology
Avian influenza virus (AIV) poses a persistent threat to global poultry production and public health. Long-term immunization programs have established a foundational immune barrier, significantly mitigating the risk of highly pathogenic avian influenza ...
Xianfeng Hui, Xianfeng Hui, Xiaowei Tian, Xiaowei Tian, Shihuan Ding, Shihuan Ding, Ge Gao, Shuoxiang Gao, Shuoxiang Gao, Aiping Sun, Aiping Sun, Tiesuo Zhao, Tiesuo Zhao, Hui Wang   +13 more
doaj   +1 more source