Results 1 to 10 of about 240,151 (268)
Cell Death Discovery, 2023 Hepatocellular carcinoma (HCC), the most prevalent type of aggressive liver cancer, accounts for the majority of liver cancer diagnoses and fatalities. Despite recent advancements in HCC treatment, it remains one of the deadliest cancers.
Huijie Jia +17 more
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Gut microbiome on immune checkpoint inhibitor therapy and consequent immune-related colitis: a review [PDF]
Intestinal Research, 2023 Immune checkpoint inhibitors have dramatically revolutionized the therapeutic landscape for patients with advanced malignancies. Recently, convincing evidence has shown meaningful influence of gut microbiome on human immune system.
Sung Wook Hwang +2 more
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Frontiers in Genetics, 2022 Many studies suggest that immune checkpoint molecules play a vital role in tumor progression and immune responses. However, the impact of the comprehensive regulation pattern of immune checkpoint molecules on immune responses, tumor microenvironment (TME)
Zili Zhen +5 more
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Metabolic Implications of Immune Checkpoint Proteins in Cancer
Cells, 2022 Expression of immune checkpoint proteins restrict immunosurveillance in the tumor microenvironment; thus, FDA-approved checkpoint inhibitor drugs, specifically PD-1/PD-L1 and CTLA-4 inhibitors, promote a cytotoxic antitumor immune response.
Elizabeth R. Stirling +5 more
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Frontiers in Immunology, 2022 Immune checkpoint inhibitors have revolutionized immunotherapy against various cancers over the last decade. The use of checkpoint inhibitors results in remarkable re-activation of patients’ immune system, but is also associated with significant adverse ...
Victoria C. Brom +3 more
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Experimental Hematology & Oncology, 2020 This letter describes the potential effect of B cell depletion on immune related adverse events associated with immune checkpoint inhibition. B cell depleting agents such as rituximab reduce B cell to plasma cell differentiation and antibody production ...
Rasmus Strøm Risbjerg +3 more
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The role of kidney biopsy in immune checkpoint inhibitor nephrotoxicity
Frontiers in Medicine, 2022 Immune checkpoint inhibitors, medications that boost host immune response to tumor cells, are now at the forefront of anti-cancer therapy. While efficacious in the treatment of patients with advanced cancer, immune checkpoint inhibitors can lead to ...
Emily M. Moss +2 more
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Frontiers in Oncology, 2022 Hepatocellular carcinoma is one of the leading causes of cancer mortality globally, and its incidence is increasing. Immune checkpoint therapy has revolutionized the treatment of hepatocellular carcinoma over the past few years.
Qingqing Xie +4 more
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Rethinking immune checkpoint blockade: ‘Beyond the T cell’
Journal for ImmunoTherapy of Cancer, 2021 The clinical success of immune checkpoint inhibitors has highlighted the central role of the immune system in cancer control. Immune checkpoint inhibitors can reinvigorate anti-cancer immunity and are now the standard of care in a number of malignancies.
Xiuting Liu +2 more
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Advanced Nanotechnology for Enhancing Immune Checkpoint Blockade Therapy
Nanomaterials, 2021 Immune checkpoint receptor signaling pathways constitute a prominent class of “immune synapse,” a cell-to-cell connection that represses T-lymphocyte effector functions.
Chiara Cremolini +3 more
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