Results 31 to 40 of about 240,151 (268)

Role of mitochondrial metabolism in immune checkpoint inhibitors-related myocarditis

Frontiers in Cardiovascular Medicine, 2023
BackgroundImmune checkpoint inhibitor-related myocarditis is the deadliest complication of immunotherapy. However, the underlying pathophysiological mechanisms of its occurrence and development remain unclear. Due to the long-term lack of effective early
Xin Zhang, Yi Gan, Haoshuai Zhu, Zhihao Liu, Xiaojing Yao, Chao Cheng, Zhenguo Liu, Chunhua Su, Jianyong Zou   +8 more
doaj   +1 more source

Immune checkpoint blockade in HIV

eBioMedicine, 2022
Antiretroviral therapy (ART) has dramatically improved life expectancy for people with HIV (PWH) and helps to restore immune function but is not curative and must be taken lifelong. Achieving long term control of HIV in the absence of ART will likely require potent T cell function, but chronic HIV infection is associated with immune exhaustion that ...
Gubser, C, Chiu, C, Lewin, SR, Rasmussen, TA   +3 more
openaire   +5 more sources

Nephrotoxicity of checkpoint inhibitors; a current challenge [PDF]

Journal of Nephropharmacology
Immune checkpoint inhibitors work by blocking the "checkpoint" mechanism that tumors use to hide from the immune system, therefore also weakening the immune system.
Samaneh Zandifar, Mahshid Imankhan, Padideh Daneii, Ali Azarpey, Leila Alem   +4 more
doaj   +1 more source

Emerging dynamics pathways of response and resistance to PD-1 and CTLA-4 blockade: tackling uncertainty by confronting complexity

Journal of Experimental & Clinical Cancer Research, 2021
Immune checkpoint inhibitors provide considerable therapeutic benefit in a range of solid cancers as well as in a subgroup of hematological malignancies.
Allan Relecom, Maysaloun Merhi, Varghese Inchakalody, Shahab Uddin, Darawan Rinchai, Davide Bedognetti, Said Dermime   +6 more
doaj   +1 more source

Immune Checkpoint Inhibitor Toxicities [PDF]

Mayo Clinic Proceedings, 2019
Immune checkpoint inhibitors are molecules that increase the endogenous immune response against tumors. They have revolutionized the field of oncology. Since their initial approval for the treatment of advanced melanoma, their use has expanded to the treatment of several other advanced cancers. Unfortunately, immune checkpoint inhibitors have also been
Julian A. Marin-Acevedo, Razvan M. Chirila, Roxana S. Dronca   +2 more
openaire   +2 more sources

Nifuroxazide suppresses PD-L1 expression and enhances the efficacy of radiotherapy in hepatocellular carcinoma

eLife
Radiation therapy is a primary treatment for hepatocellular carcinoma (HCC), but its effectiveness can be diminished by various factors. The over-expression of PD-L1 has been identified as a critical reason for radiotherapy resistance.
Tiesuo Zhao, Pengkun Wei, Congli Zhang, Shijie Zhou, Lirui Liang, Shuoshuo Guo, Zhinan Yin, Sichang Cheng, Zerui Gan, Yuanling Xia, Yongxi Zhang, Sheng Guo, Jiateng Zhong, Zishan Yang, Fei Tu, Qianqing Wang, Jin Bai, Feng Ren, Zhiwei Feng, Huijie Jia   +19 more
doaj   +1 more source

Reprogramming the tumor microenvironment to overcome immunotherapy resistance in pancreatic cancer

Frontiers in Immunology
BackgroundPancreatic ductal adenocarcinoma (PDAC) exhibits profound resistance to immunotherapy due to its highly immunosuppressive tumor microenvironment (TME).ObjectiveThis review aims to elucidate the key mechanisms of TME-mediated immune evasion in ...
Xianfeng Hui, Xianfeng Hui, Xianfeng Hui, Xiaowei Tian, Shihuan Ding, Shihuan Ding, Shihuan Ding, Aiping Sun, Tiesuo Zhao, Tiesuo Zhao, Hui Wang, Hui Wang   +11 more
doaj   +1 more source

Immune Checkpoint Molecules in Reproductive Immunology

Frontiers in Immunology, 2019
Immune checkpoint molecules, like CTLA-4, TIM-3, PD-1, are negative regulators of immune responses to avoid immune injury. Checkpoint regulators are thought to actively participate in the immune defense of infections, prevention of autoimmunity ...
Eva Miko, Eva Miko, Matyas Meggyes, Matyas Meggyes, Katalin Doba, Aliz Barakonyi, Aliz Barakonyi, Laszlo Szereday, Laszlo Szereday   +8 more
doaj   +1 more source

Gut microbiota shed new light on the management of immune‐related adverse events

Thoracic Cancer, 2022
Immunotherapy has dramatically revolutionized the therapeutic landscape for patients with cancer. Although immune checkpoint inhibitors are now accepted as effective anticancer therapies, they introduce a novel class of toxicity, termed immune‐related ...
Bei Tan, Yun‐xin Liu, Hao Tang, Dan Chen, Yan Xu, Min‐jiang Chen, Yue Li, Meng‐zhao Wang, Jia‐ming Qian   +8 more
doaj   +1 more source

Regulation of Intrinsic Functions of PD-L1 by Post-Translational Modification in Tumors

Frontiers in Oncology, 2022
Tumor cells are eliminated by the immune system, including T lymphocytes and natural killer cells; however, many types of tumor cells acquire the immune tolerance by inhibiting T-cell activation and functions via immune checkpoint molecules ...
Naoe Taira Nihira, Naoe Taira Nihira, Yoshio Miki   +2 more
doaj   +1 more source