Results 31 to 40 of about 1,332,792 (304)
Nano-Chemotherapy synergize with immune checkpoint inhibitor- A better option?
Frontiers in Immunology, 2022 Immune checkpoint inhibitor (ICI) is one of the most important tumor treatment methods. Although the therapeutic efficiency of immune checkpoint inhibitor mono-therapy is limited, the combination of chemotherapy plus immune checkpoint inhibitors has ...
Xinye Qian +5 more
doaj +1 more source
Advanced Nanotechnology for Enhancing Immune Checkpoint Blockade Therapy
Nanomaterials, 2021 Immune checkpoint receptor signaling pathways constitute a prominent class of “immune synapse,” a cell-to-cell connection that represses T-lymphocyte effector functions.
Chiara Cremolini +3 more
doaj +1 more source
Cancer Biology & Medicine, 2015 Immune checkpoint inhibitors are increasingly drawing much attention in the therapeutic development for cancer treatment. However, many cancer patients do not respond to treatments with immune checkpoint inhibitors, partly because of the lack of tumor ...
Jennifer Kleponis +2 more
doaj +1 more source
OncoImmunology, 2021 Immune checkpoint therapy has resulted in minimal clinical response in many pediatric cancers. We sought to understand the influence of immune checkpoint inhibition using anti-PD-1 and anti-CTLA-4 antibodies individually, in combination, and after ...
Soheila Shirinbak +13 more
doaj +1 more source
Immune Checkpoint Inhibitors and Kidney Toxicity: Advances in Diagnosis and Management
Kidney Medicine, 2021 Immune checkpoint inhibitors are now approved for more than 50 indications, and increasing numbers of patients with advanced cancer are receiving immunotherapy.
Harish Seethapathy +2 more
doaj +1 more source
Journal of Hematology & Oncology, 2017 Adaptive immunity is critical for disease progression and modulates T cell (TC) and antigen-presenting cell (APC) functions. Three signals were initially proposed for adaptive immune activation: signal 1 antigen recognition, signal 2 co-stimulation or co-
Jin Dai +10 more
doaj +1 more source
Bub3p facilitates spindle checkpoint silencing in fission yeast [PDF]
, 2009 Although critical for spindle checkpoint signaling, the role kinetochores play in anaphase promoting complex (APC) inhibition remains unclear. Here we show that spindle checkpoint proteins are severely depleted from unattached kinetochores in fission ...
Hardwick, Kevin G. +13 more
core +1 more source
Myocarditis with Immune Checkpoint Blockade [PDF]
New England Journal of Medicine, 2017 In their discussion of fulminant myocarditis and complete heart block during immune checkpoint therapy, Johnson et al. do not discuss the possible role of circulating anticonductive tissue autoantibodies (ACTA) in the pathogenesis of the sudden heart block and myocarditis.1 Since it is not known which autoantigens (other than troponin I, which was ...
Javid J, Moslehi +2 more
openaire +5 more sources
Immune Checkpoint Inhibitors in Triple Negative Breast Cancer Treatment: Promising Future Prospects
Frontiers in Oncology, 2021 Immunotherapy has emerged as the fifth pillar of cancer treatment alongside surgery, radiotherapy, chemotherapy, and targeted therapy. Immune checkpoint inhibitors are the current superheroes of immunotherapy, unleashing a patient’s own immune cells to ...
Remy Thomas +4 more
doaj +1 more source
Immune phenotypes of prostate cancer cells: Evidence of epithelial immune cell-like transition?
Asian Journal of Urology, 2016 Prostate cancers (PCa) have been reported to actively suppress antitumor immune responses by creating an immune-suppressive microenvironment. There is mounting evidence that PCas may undergo an ‘‘Epithelial Immune Cell-like Transition’’ (EIT) by ...
Dong Lin +5 more
doaj +1 more source