Results 31 to 40 of about 242,665 (269)

Adverse effects of immune checkpoint inhibitor therapies on right ventricular function and pulmonary arterial dilatation

Pulmonary Circulation, 2021
Immunologic risk factors contribute to endothelial dysfunction and development of pulmonary vascular disease. Immune checkpoint inhibitors, used as immunotherapies for malignancies, have a wide range of reported immune-related adverse events.
Ruben Mylvaganam, Ryan Avery, Isaac Goldberg, Courtney Makowski, Ravi Kalhan, Victoria Villaflor, Michael J. Cuttica   +6 more
doaj   +1 more source

Nifuroxazide suppresses PD-L1 expression and enhances the efficacy of radiotherapy in hepatocellular carcinoma

eLife
Radiation therapy is a primary treatment for hepatocellular carcinoma (HCC), but its effectiveness can be diminished by various factors. The over-expression of PD-L1 has been identified as a critical reason for radiotherapy resistance.
Tiesuo Zhao, Pengkun Wei, Congli Zhang, Shijie Zhou, Lirui Liang, Shuoshuo Guo, Zhinan Yin, Sichang Cheng, Zerui Gan, Yuanling Xia, Yongxi Zhang, Sheng Guo, Jiateng Zhong, Zishan Yang, Fei Tu, Qianqing Wang, Jin Bai, Feng Ren, Zhiwei Feng, Huijie Jia   +19 more
doaj   +1 more source

Immune checkpoint blockade in HIV

eBioMedicine, 2022
Antiretroviral therapy (ART) has dramatically improved life expectancy for people with HIV (PWH) and helps to restore immune function but is not curative and must be taken lifelong. Achieving long term control of HIV in the absence of ART will likely require potent T cell function, but chronic HIV infection is associated with immune exhaustion that ...
Gubser, C, Chiu, C, Lewin, SR, Rasmussen, TA   +3 more
openaire   +5 more sources

Reprogramming the tumor microenvironment to overcome immunotherapy resistance in pancreatic cancer

Frontiers in Immunology
BackgroundPancreatic ductal adenocarcinoma (PDAC) exhibits profound resistance to immunotherapy due to its highly immunosuppressive tumor microenvironment (TME).ObjectiveThis review aims to elucidate the key mechanisms of TME-mediated immune evasion in ...
Xianfeng Hui, Xianfeng Hui, Xianfeng Hui, Xiaowei Tian, Shihuan Ding, Shihuan Ding, Shihuan Ding, Aiping Sun, Tiesuo Zhao, Tiesuo Zhao, Hui Wang, Hui Wang   +11 more
doaj   +1 more source

The Role of Chemotherapy in Pediatric Myoepithelial Carcinoma: A Systematic Review of the Literature

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Myoepithelial carcinoma (MEC) in pediatric patients is a rare and aggressive malignancy characterized by heterogeneous morphology and variable molecular features. The optimal role of chemotherapy remains unclear. We conducted a systematic review according to PRISMA 2020 guidelines to evaluate chemotherapy in pediatric and young‐adult patients ...
Marco Salvi, Maria Carmen Affinita, Giulia Fichera, Luisa Santoro, Angela Scagnellato, Calogero Virgone, Elena Poli, Gianni Bisogno   +7 more
wiley   +1 more source

Advances and prospects of mucosal vaccination in the prevention and control of avian influenza

Frontiers in Immunology
Avian influenza virus (AIV) poses a persistent threat to global poultry production and public health. Long-term immunization programs have established a foundational immune barrier, significantly mitigating the risk of highly pathogenic avian influenza ...
Xianfeng Hui, Xianfeng Hui, Xiaowei Tian, Xiaowei Tian, Shihuan Ding, Shihuan Ding, Ge Gao, Shuoxiang Gao, Shuoxiang Gao, Aiping Sun, Aiping Sun, Tiesuo Zhao, Tiesuo Zhao, Hui Wang   +13 more
doaj   +1 more source

Immune Checkpoint Molecules in Reproductive Immunology

Frontiers in Immunology, 2019
Immune checkpoint molecules, like CTLA-4, TIM-3, PD-1, are negative regulators of immune responses to avoid immune injury. Checkpoint regulators are thought to actively participate in the immune defense of infections, prevention of autoimmunity ...
Eva Miko, Eva Miko, Matyas Meggyes, Matyas Meggyes, Katalin Doba, Aliz Barakonyi, Aliz Barakonyi, Laszlo Szereday, Laszlo Szereday   +8 more
doaj   +1 more source

Immune Checkpoint Inhibitor Toxicities [PDF]

Mayo Clinic Proceedings, 2019
Immune checkpoint inhibitors are molecules that increase the endogenous immune response against tumors. They have revolutionized the field of oncology. Since their initial approval for the treatment of advanced melanoma, their use has expanded to the treatment of several other advanced cancers. Unfortunately, immune checkpoint inhibitors have also been
Julian A. Marin-Acevedo, Razvan M. Chirila, Roxana S. Dronca   +2 more
openaire   +2 more sources

Occurrence of Extramedullary Relapses in Pediatric Acute Lymphoblastic Leukemia After Treatment With Blinatumomab

Pediatric Blood &Cancer, EarlyView.
ABSTRACT We report a retrospective single‐center analysis of pediatric patients with relapsed or refractory B‐cell precursor acute lymphoblastic leukemia focusing on relapses outside of the typical locations, bone marrow, central nervous system, or testes.
Johanna Kunz, Martin Ebinger, Michaela Döring, Markus Mezger, Ursula Holzer, Rupert Handgretinger, Peter Lang, Manon Queudeville   +7 more
wiley   +1 more source

MiR-362-3p inhibits the proliferation, migration and EMT of gastric cancer cells by regulating the DEP-1/ERK signaling pathway

Scientific Reports
MicroRNAs (miRNAs) play a very important role in the development of gastric cancer (GC). MiR-362-3p participates in the formation and progression of various cancers. However, the role and clinical value of miR-362-3p in GC remain unclear.
Fei Tu, Zhiyuan Li, Lina Yao, Fengyuan He, Yiqing Jia, Lingzhu Wang, Tiesuo Zhao, Sheng Guo, Yan Jin, Zhijun Yang   +9 more
doaj   +1 more source