Results 41 to 50 of about 242,665 (269)
The APC/C subunit APC7 exerts antiviral effects by targeting the adaptor protein MAVS
Frontiers in ImmunologyThe innate immune response is the first line of host defense against viral infection. RNA virus infection triggers activation of retinoic acid-inducible gene-I (RIG-I)-mitochondrial antiviral signaling protein (MAVS) signaling pathway, resulting in the ...
Rui Su +6 more
doaj +1 more source
Immune Checkpoint Inhibitors in Melanoma [PDF]
Melanoma Management, 2015 The potential to harness the power of the immune system and effectively treat patients with metastatic melanoma is finally being realized with the advent of immune checkpoint inhibitors. These new therapies herald a new era in the treatment of melanoma with the potential to produce very durable responses and possible cure for a subset of patients ...
Adam J, Cooper +2 more
openaire +2 more sources
Scientific ReportsMicroRNAs (miRNAs) play a very important role in the development of gastric cancer (GC). MiR-30a-5p Participates in the formation and progression of various cancers. However, the role and clinical value of miR-30a-5p in GC remain unclear.
Fei Tu +8 more
doaj +1 more source
CBX4 facilitates EV71 replication by SUMOylation and stabilizing 3D polymerase
Frontiers in MicrobiologyEnterovirus 71 (EV71) is a primary etiological agent of hand-foot-mouth disease (HFMD) in children under 5 years of age and can cause severe neurological disorders even death.
Rui Su +6 more
doaj +1 more source
Key questions about the checkpoint blockade-are microRNAs an answer?
Cancer Biology & Medicine, 2018 The introduction of immune-checkpoint blockade in the cancer therapy led to a paradigm change of the management of late stage cancers. There are already multiple FDA approved checkpoint inhibitors and many other agents are undergoing phase 2 and early ...
Mihnea Dragomir +3 more
doaj +1 more source
Gut microbiota shed new light on the management of immune‐related adverse events
Thoracic Cancer, 2022 Immunotherapy has dramatically revolutionized the therapeutic landscape for patients with cancer. Although immune checkpoint inhibitors are now accepted as effective anticancer therapies, they introduce a novel class of toxicity, termed immune‐related ...
Bei Tan +8 more
doaj +1 more source
Organoids in pediatric cancer research
FEBS Letters, EarlyView.Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley +1 more source
Frontiers in ImmunologyWith global viral emergence and increasing antiviral resistance, there is an urgent need for innovative immunomodulatory strategies. Gut microbiota modulation has gained attention as a promising therapeutic approach. Clostridium butyricum (C.
Shaoju Qian +14 more
doaj +1 more source
Regulation of Intrinsic Functions of PD-L1 by Post-Translational Modification in Tumors
Frontiers in Oncology, 2022 Tumor cells are eliminated by the immune system, including T lymphocytes and natural killer cells; however, many types of tumor cells acquire the immune tolerance by inhibiting T-cell activation and functions via immune checkpoint molecules ...
Naoe Taira Nihira +2 more
doaj +1 more source
Negative Immune Checkpoint Inhibitors
PharmaceuticsCheckpoint inhibitors are a modern therapeutic approach for treating various types of cancer, metabolic diseases, and chronic infections. The main goal of this therapy is to specifically unlock the immune system, allowing it to recognize and eliminate cancer cells or pathogens, primarily through the activation of T lymphocytes.
Magda Drewniak-Świtalska +2 more
openaire +4 more sources