Gut microbiota shed new light on the management of immune‐related adverse events
Thoracic Cancer, 2022 Immunotherapy has dramatically revolutionized the therapeutic landscape for patients with cancer. Although immune checkpoint inhibitors are now accepted as effective anticancer therapies, they introduce a novel class of toxicity, termed immune‐related ...
Bei Tan +8 more
doaj +1 more source
Nivolumab-induced fulminant diabetic ketoacidosis followed by thyroiditis [PDF]
, 2018 Five days following the 3rd cycle of nivolumab, a monoclonal antibody, which acts as immune checkpoint inhibitor against the programmed cell death protein-1, for metastatic lung adenocarcinoma, a 56-year-old woman presented at the hospital critically ill.
Baker, E +6 more
core +2 more sources
Reprogramming the tumor microenvironment to overcome immunotherapy resistance in pancreatic cancer
Frontiers in ImmunologyBackgroundPancreatic ductal adenocarcinoma (PDAC) exhibits profound resistance to immunotherapy due to its highly immunosuppressive tumor microenvironment (TME).ObjectiveThis review aims to elucidate the key mechanisms of TME-mediated immune evasion in ...
Xianfeng Hui +11 more
doaj +1 more source
Journal of Experimental & Clinical Cancer Research, 2021 Immune checkpoint inhibitors provide considerable therapeutic benefit in a range of solid cancers as well as in a subgroup of hematological malignancies.
Allan Relecom +6 more
doaj +1 more source
NQO1 targeting prodrug triggers innate sensing to overcome checkpoint blockade resistance [PDF]
, 2019 Lack of proper innate sensing inside tumor microenvironment (TME) limits T cell-targeted immunotherapy. NAD(P)H:quinone oxidoreductase 1 (NQO1) is highly enriched in multiple tumor types and has emerged as a promising target for direct tumor-killing ...
Boothman, David A. +10 more
core +1 more source
Advances and prospects of mucosal vaccination in the prevention and control of avian influenza
Frontiers in ImmunologyAvian influenza virus (AIV) poses a persistent threat to global poultry production and public health. Long-term immunization programs have established a foundational immune barrier, significantly mitigating the risk of highly pathogenic avian influenza ...
Xianfeng Hui +13 more
doaj +1 more source
Immune Checkpoint Molecules in Reproductive Immunology
Frontiers in Immunology, 2019 Immune checkpoint molecules, like CTLA-4, TIM-3, PD-1, are negative regulators of immune responses to avoid immune injury. Checkpoint regulators are thought to actively participate in the immune defense of infections, prevention of autoimmunity ...
Eva Miko +8 more
doaj +1 more source
Regulation of Intrinsic Functions of PD-L1 by Post-Translational Modification in Tumors
Frontiers in Oncology, 2022 Tumor cells are eliminated by the immune system, including T lymphocytes and natural killer cells; however, many types of tumor cells acquire the immune tolerance by inhibiting T-cell activation and functions via immune checkpoint molecules ...
Naoe Taira Nihira +2 more
doaj +1 more source
Neurological complications of immune checkpoint inhibitors: what happens when you \u27take the brakes off\u27 the immune system. [PDF]
, 2018 Patients with advanced malignancies treated with immune checkpoint inhibitors are at increased risk for developing immune-related neurological complications.
Dalakas, Marinos
core +1 more source
Immunotherapy in hepatocellular carcinoma: the complex interface between inflammation, fibrosis, and the immune response. [PDF]
, 2019 Hepatocellular carcinoma (HCC) is the third leading cause of cancer deaths worldwide and confers a poor prognosis. Beyond standard systemic therapy with multikinase inhibitors, recent studies demonstrate the potential for robust and durable responses ...
Fong, Lawrence +2 more
core +2 more sources