Results 41 to 50 of about 240,151 (268)

Three phosphatase families form a community: The phosphohydrolases that act upon inositol pyrophosphates

FEBS Letters, EarlyView.
Inositol pyrophosphates are energy‐rich signaling molecules that perform critical functions in cells. Three different families of phosphatases hydrolyze the β phosphate of the inositol pyrophosphate molecules: two have narrow specificities and one is promiscuous.
Ronda J. Rolfes
wiley   +1 more source

Advances and prospects of mucosal vaccination in the prevention and control of avian influenza

Frontiers in Immunology
Avian influenza virus (AIV) poses a persistent threat to global poultry production and public health. Long-term immunization programs have established a foundational immune barrier, significantly mitigating the risk of highly pathogenic avian influenza ...
Xianfeng Hui, Xianfeng Hui, Xiaowei Tian, Xiaowei Tian, Shihuan Ding, Shihuan Ding, Ge Gao, Shuoxiang Gao, Shuoxiang Gao, Aiping Sun, Aiping Sun, Tiesuo Zhao, Tiesuo Zhao, Hui Wang   +13 more
doaj   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

MiR-362-3p inhibits the proliferation, migration and EMT of gastric cancer cells by regulating the DEP-1/ERK signaling pathway

Scientific Reports
MicroRNAs (miRNAs) play a very important role in the development of gastric cancer (GC). MiR-362-3p participates in the formation and progression of various cancers. However, the role and clinical value of miR-362-3p in GC remain unclear.
Fei Tu, Zhiyuan Li, Lina Yao, Fengyuan He, Yiqing Jia, Lingzhu Wang, Tiesuo Zhao, Sheng Guo, Yan Jin, Zhijun Yang   +9 more
doaj   +1 more source

CBX4 facilitates EV71 replication by SUMOylation and stabilizing 3D polymerase

Frontiers in Microbiology
Enterovirus 71 (EV71) is a primary etiological agent of hand-foot-mouth disease (HFMD) in children under 5 years of age and can cause severe neurological disorders even death.
Rui Su, Yifan Niu, Aiping Sun, Aiping Sun, Tiesuo Zhao, Tiesuo Zhao, Hui Wang   +6 more
doaj   +1 more source

Key questions about the checkpoint blockade-are microRNAs an answer?

Cancer Biology & Medicine, 2018
The introduction of immune-checkpoint blockade in the cancer therapy led to a paradigm change of the management of late stage cancers. There are already multiple FDA approved checkpoint inhibitors and many other agents are undergoing phase 2 and early ...
Mihnea Dragomir, Baoqing Chen, Xiao Fu, George A. Calin   +3 more
doaj   +1 more source

Subtype‐specific enhancer RNAs define transcriptional regulators and prognosis in breast cancers

Molecular Oncology, EarlyView.
This study employed machine learning methodologies to perform the subtype‐specific classification of RNA‐seq data sets, which are mapped on enhancers from TCGA‐derived breast cancer patients. Their integration with gene expression (referred to as ProxCReAM eRNAs) and chromatin accessibility profiles has the potential to identify lineage‐specific and ...
Aamena Y. Patel, Peyman Zarrineh, Nathnael T. Tuffa, Jigar H. Sheth, Sumitra Mohan, Mudassar Iqbal, Sankari Nagarajan   +6 more
wiley   +1 more source

MiR-30a-5p activates the AKT signalling pathway by targeting PHTF2 to inhibit migration and EMT of gastric cancer

Scientific Reports
MicroRNAs (miRNAs) play a very important role in the development of gastric cancer (GC). MiR-30a-5p Participates in the formation and progression of various cancers. However, the role and clinical value of miR-30a-5p in GC remain unclear.
Fei Tu, Fengyuan He, Zhiyuan Li, Yiqing Jia, Lingzhu Wang, Tiesuo Zhao, Sheng Guo, Yan Jin, Zhijun Yang   +8 more
doaj   +1 more source

The role of Clostridium butyricum and its metabolites in modulating gut mucosal immunity: implications for viral infections and inflammatory diseases

Frontiers in Immunology
With global viral emergence and increasing antiviral resistance, there is an urgent need for innovative immunomodulatory strategies. Gut microbiota modulation has gained attention as a promising therapeutic approach. Clostridium butyricum (C.
Shaoju Qian, Shaoju Qian, Shaoju Qian, Siyu Li, Keyan Ye, Shuao Lu, Xiaoming Sha, Danqiong Zhang, Zhishan Xu, Zhishan Xu, Zhishan Xu, Xiangfeng Song, Xiangfeng Song, Xiangfeng Song, Ruixue Li   +14 more
doaj   +1 more source

Pneumonitis and multiple pneumonial infections under combined immune‐checkpoint inhibition

JEADV Clinical Practice, 2023
The introduction of immune checkpoint inhibitors and targeted therapies has revolutionized melanoma treatment. The downside are immune‐mediated adverse events which are frequent and require close patient management.
Kristine E. Mayer, Thomas Gan, Jochen Gaa, Tilo Biedermann, Christian Posch   +4 more
doaj   +1 more source