Results 1 to 10 of about 81,816 (117)

A homozygous CTLA-4 variant causes CTLA-4 deficiency with severe immune dysregulationNovel homozygous CTLA-4 variant in immune dysregulation [PDF]

Journal of Human Immunity
Catak et al. describe the first case of homozygous CTLA-4 deficiency, which drives severe early-onset autoimmunity through profound T and B cell dysregulation.
Mehmet Cihangir Catak, Salim Can, Satanay Hubrack, Feyza Bayram Catak, Asha Elmi, Royala Babayeva, Razin Amirov, Melek Yorgun Altunbas, Sevgi Bilgic Eltan, Deniz Ertem, Baris Yilmaz, Ahmet Koc, Batu Erman, Emine Bozkurtlar, Elif Karakoc-Aydiner, Ahmet Ozen, Bernice Lo, Safa Baris   +17 more
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Autosomal recessive human CTLA-4 deficiency with autoimmune infiltrationHuman CTLA-4 deficiency [PDF]

Journal of Human Immunity
A report in this issue of JHI deepens our understanding of human disease associated with loss of CTLA-4.
Helen C. Su
doaj   +2 more sources

DNA-PKcs orchestrates CTLA-4 depletion-induced senescence in cancer cells [PDF]

Cell Death and Disease
Immune checkpoints such as cytotoxic T-lymphocyte–associated protein 4 (CTLA-4), programmed cell death 1 (PD-1), and programmed cell death ligand 1 (PD-L1) have been targeted in cancer therapy, however, the efficacy of these interventions remains limited.
Je-Jung Lee, Woo Joong Rhee, So Young Kim, Jisun Lee, Su Ful Jung, Jooyeon Oh, In Ho Park, Jeon-Soo Shin   +7 more
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The Association Between CTLA-4, CD80/86, and CD28 Gene Polymorphisms and Rheumatoid Arthritis: An Original Study and Meta-Analysis

Frontiers in Medicine, 2021
Background: Rheumatoid arthritis (RA) is related to several pivotal susceptibility genes, including cytotoxic T-lymphocyte-associated protein 4 (CTLA-4) and costimulatory molecule (CD80/CD86) genes. Although the connection between polymorphisms of CTLA-4
Weixi Liu, Zhicheng Yang, Yan Chen, Haoyu Yang, Xiaoxian Wan, Xindie Zhou, Ruiping Liu, Yunkun Zhang   +7 more
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64Cu-DOTA-anti-CTLA-4 mAb enabled PET visualization of CTLA-4 on the T-cell infiltrating tumor tissues. [PDF]

PLoS ONE, 2014
Cytotoxic T lymphocyte-associated antigen-4 (CTLA-4) targeted therapy by anti-CTLA-4 monoclonal antibody (mAb) is highly effective in cancer patients.
Kei Higashikawa, Katsuharu Yagi, Keiko Watanabe, Shinichiro Kamino, Masashi Ueda, Makoto Hiromura, Shuichi Enomoto   +6 more
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Identification of CTLA-4-Positive Cells in the Human Tonsil

Cells, 2021
CTLA-4 (cytotoxic T-lymphocyte-associated protein 4) was originally defined as a T-lymphocyte antigen and was used as a target in cancer immunotherapy. Unfortunately, the existence of CTLA-4 in cells other than T-lymphocytes is often overlooked. The goal
Markus Tiemann, Dmitri Atiakshin, Vera Samoilova, Igor Buchwalow   +3 more
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Characterization of the high-affinity anti-CTLA-4 monoclonal antibody JS007 for immune checkpoint therapy of cancer

mAbs, 2023
Cytotoxic T lymphocyte-associated antigen 4 (CTLA-4) is a critical inhibitory checkpoint molecule, and monoclonal antibodies (mAbs) targeting CTLA-4 that restore anti-tumor T cell immunity have achieved clinical success.
Jiawei Guan, Hongchuan Liu, Yan Chai, Jie Yu, Jian Yao, Jing Wang, Zhiwei Pan, Jing Zhang, Yuehua Zhou, Hui Liu, Sheng Yao, Jianxun Qi, Hui Feng, George F. Gao, Qihui Wang, Yi Shi, Shuguang Tan   +16 more
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Development of a Highly Sensitive Hybrid LC/MS Assay for the Quantitative Measurement of CTLA-4 in Human T Cells

Molecules, 2023
Cytotoxic T-lymphocyte-associated protein 4 (CTLA-4) is a check point protein expressed on the surface of T cells and plays a central role in regulating the immune response.
Dong Wei, Kristin L. Horton, John Chen, Linlin Dong, Susan Chen, Kojo Abdul-Hadi, Ting Ting Zhang, Cierra N. Casson, Michael Shaw, Tsubasa Shiraishi, Brandon Wilkinson, Chengjie Ji, Mark G. Qian   +12 more
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A functional antibody cross-reactive to both human and murine cytotoxic T-lymphocyte-associated protein 4 via binding to an N-glycosylation epitope

mAbs, 2020
Cytotoxic T-lymphocyte-associated protein 4 (CTLA-4, CD152) is a receptor on T cells that inhibits the cell’s functions. Blocking CTLA-4 with an antibody has proven effective for the treatment of cancer patients. Anti-CTLA-4 antibodies currently approved
Dong Li, Jing Li, Huanyu Chu, Zhuozhi Wang   +3 more
doaj   +1 more source

Immune inhibitory function of bovine CTLA-4 and the effects of its blockade in IFN-γ production

BMC Veterinary Research, 2019
Background Cytotoxic T-lymphocyte antigen 4 (CTLA-4) is known as an immune inhibitory receptor that is expressed on activated effector T cells and regulatory T cells. When CTLA-4 binds to CD80 or CD86, immunoinhibitory signals are transmitted to retain a
Kei Watari, Satoru Konnai, Naoya Maekawa, Tomohiro Okagawa, Yasuhiko Suzuki, Shiro Murata, Kazuhiko Ohashi   +6 more
doaj   +1 more source