Results 21 to 30 of about 22,609,350 (346)

Characterization of the high-affinity anti-CTLA-4 monoclonal antibody JS007 for immune checkpoint therapy of cancer

mAbs, 2023
Cytotoxic T lymphocyte-associated antigen 4 (CTLA-4) is a critical inhibitory checkpoint molecule, and monoclonal antibodies (mAbs) targeting CTLA-4 that restore anti-tumor T cell immunity have achieved clinical success.
Jiawei Guan, Hongchuan Liu, Yan Chai, Jie Yu, Jian Yao, Jing Wang, Zhiwei Pan, Jing Zhang, Yuehua Zhou, Hui Liu, Sheng Yao, Jianxun Qi, Hui Feng, George F. Gao, Qihui Wang, Yi Shi, Shuguang Tan   +16 more
doaj   +1 more source

Development of a Highly Sensitive Hybrid LC/MS Assay for the Quantitative Measurement of CTLA-4 in Human T Cells

Molecules, 2023
Cytotoxic T-lymphocyte-associated protein 4 (CTLA-4) is a check point protein expressed on the surface of T cells and plays a central role in regulating the immune response.
Dong Wei, Kristin L. Horton, John Chen, Linlin Dong, Susan Chen, Kojo Abdul-Hadi, Ting Ting Zhang, Cierra N. Casson, Michael Shaw, Tsubasa Shiraishi, Brandon Wilkinson, Chengjie Ji, Mark G. Qian   +12 more
doaj   +1 more source

A functional antibody cross-reactive to both human and murine cytotoxic T-lymphocyte-associated protein 4 via binding to an N-glycosylation epitope

mAbs, 2020
Cytotoxic T-lymphocyte-associated protein 4 (CTLA-4, CD152) is a receptor on T cells that inhibits the cell’s functions. Blocking CTLA-4 with an antibody has proven effective for the treatment of cancer patients. Anti-CTLA-4 antibodies currently approved
Dong Li, Jing Li, Huanyu Chu, Zhuozhi Wang   +3 more
doaj   +1 more source

Augmentation of CTLA-4 expression by wortmannin: involvement of lysosomal sorting properties of CTLA-4 [PDF]

International Immunology, 1999
CTLA-4 (CD152) is transiently induced on the cell surface of activated T cells and expression is limited at a low level. In this study, we investigated the possibility that phosphatidylinositol 3 kinase (PI 3-K) and other related PI kinases associated with the cytoplasmic domain of CTLA-4 are involved in intracellular trafficking and sorting of CTLA-4 ...
S, Oki, T, Kohsaka, M, Azuma
openaire   +2 more sources

Safety and clinical activity of combined PD-1 (nivolumab) and CTLA-4 (ipilimumab) blockade in advanced melanoma patients

New England Journal of Medicine, 2013
Background In patients with melanoma, ipilimumab (anti-CTLA-4) prolongs overall survival and nivolumab (anti-PD-1) produced durable tumor regressions in a phase 1 trial.
J. Wolchok, H. Kluger, M. Callahan, M. Postow, N. Rizvi, A. Lesokhin, N. Segal, C. Ariyan, R. Gordon, Kathleen Reed, M. Burke, A. Caldwell, S. Kronenberg, B. Agunwamba, Xiaoling Zhang, I. Lowy, H. Inzunza, W. Feely, C. Horak, Q. Hong, A. Korman, J. Wigginton, A. Gupta, M. Sznol   +23 more
semanticscholar   +1 more source

The CTLA-4 and PD-1/PD-L1 inhibitory pathways independently regulate host resistance to Plasmodium-induced acute immune pathology. [PDF]

, 2012
The balance between pro-inflammatory and regulatory immune responses in determining optimal T cell activation is vital for the successful resolution of microbial infections.
Couper, Kevin N, Claser, C, Riley, Eleanor M, Julius Clemence R Hafalla, Eleanor M Riley, Kevin N Couper, de Souza, J Brian, de Souza, J. Brian, Claser Carla, Renia L., Kevin N. Couper (25399), Grau, GE, Hafalla Julius Clemence R., Laurent Renia (63769), Couper, KN, Hafalla, Julius Clemence R, Grau G.E., Couper Kevin N., Grau, Georges Emile, de Souza, JB, Riley Eleanor M., J. Brian de Souza (25406), Claser C., Renia Laurent, Riley E.M., Hafalla J.C.R., Julius Clemence R. Hafalla (185909), de Souza J.B., de Souza J. Brian, Hafalla, JC, Riley, Eleanor M., Couper K.N., Renia, Laurent, Carla Claser, Georges Emile Grau, Carla Claser (185910), Couper, Kevin N., Georges Emile Grau (185911), Renia, L, Riley, EM, J Brian de Souza, Eleanor M. Riley (25407), Grau Georges Emile, Laurent Renia, Claser, Carla   +44 more
core   +1 more source

Immune inhibitory function of bovine CTLA-4 and the effects of its blockade in IFN-γ production

BMC Veterinary Research, 2019
Background Cytotoxic T-lymphocyte antigen 4 (CTLA-4) is known as an immune inhibitory receptor that is expressed on activated effector T cells and regulatory T cells. When CTLA-4 binds to CD80 or CD86, immunoinhibitory signals are transmitted to retain a
Kei Watari, Satoru Konnai, Naoya Maekawa, Tomohiro Okagawa, Yasuhiko Suzuki, Shiro Murata, Kazuhiko Ohashi   +6 more
doaj   +1 more source

CTLA-4 promotes lymphoma progression through tumor stem cell enrichment and immunosuppression

Open Life Sciences, 2021
The recurrence rate of lymphoma is very high, and tumor stem cells may be an important mechanism. Cytotoxic T lymphocyte-associated antigen 4 (CTLA-4) can inhibit antitumor immunity and promote cancer progression, but its role and mechanism in lymphoma ...
Chen Yan, Li Meng, Cao Jian, Cai Guohong, Li Xiantao, Liu Yuejiao, Chen Wen   +6 more
doaj   +1 more source

Anticancer immunotherapy by CTLA-4 blockade relies on the gut microbiota

Science, 2015
Gut microbes affect immunotherapy The unleashing of antitumor T cell responses has ushered in a new era of cancer treatment. Although these therapies can cause dramatic tumor regressions in some patients, many patients inexplicably see no benefit.
Marie Vetizou, J. Pitt, Romain Daillère, P. Lepage, N. Waldschmitt, C. Flament, S. Rusakiewicz, B. Routy, M. Roberti, Connie P. M. Duong, Vichnou Poirier-Colame, A. Roux, S. Becharef, S. Formenti, E. Golden, Sascha Cording, G. Eberl, A. Schlitzer, F. Ginhoux, S. Mani, T. Yamazaki, Nicolas Jacquelot, D. Enot, M. Bérard, J. Nigou, P. Opolon, A. Eggermont, P. Woerther, E. Chachaty, N. Chaput, C. Robert, C. Mateus, G. Kroemer, D. Raoult, I. Boneca, F. Carbonnel, M. Chamaillard, L. Zitvogel   +37 more
semanticscholar   +1 more source

Comparison of the intracellular trafficking itinerary of ctla-4 orthologues.

PLoS ONE, 2013
CTLA-4 is an essential inhibitor of T cell immune responses. At steady state, most CTLA-4 resides in intracellular compartments due to constitutive internalisation mediated via a tyrosine based endocytic motif (YVKM) within the cytoplasmic domain.
Satdip Kaur, Omar S Qureshi, David M Sansom   +2 more
doaj   +1 more source