64Cu-DOTA-anti-CTLA-4 mAb enabled PET visualization of CTLA-4 on the T-cell infiltrating tumor tissues. [PDF]
PLoS ONE, 2014 Cytotoxic T lymphocyte-associated antigen-4 (CTLA-4) targeted therapy by anti-CTLA-4 monoclonal antibody (mAb) is highly effective in cancer patients.
Kei Higashikawa +6 more
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Potent Inhibition of CTLA-4 Expression by an Anti-CTLA-4 Ribozyme
Biochemical and Biophysical Research Communications, 1998 Blockading the negative-regulatory CTLA-4 receptor has emerged as a powerful strategy with clinical potential to enhance T-cell responses. Some experimental tumors, for example, are rejected when anti-CTLA-4 antibodies are administered in vivo. The concise target cells and downstream events, however, remain to be defined.
E, Cepero +3 more
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Activated CTLA‐4‐independent immunosuppression of Treg cells disturbs CTLA‐4 blockade‐mediated antitumor immunity [PDF]
Cancer Science, 2023 Combination therapy with anti‐cytotoxic T lymphocyte‐associated protein 4 (CTLA‐4) and anti‐programmed death‐1 (PD‐1) monoclonal antibodies (mAbs) has dramatically improved the prognosis of patients with multiple types of cancer, including renal cell ...
Tomofumi Watanabe +7 more
semanticscholar +2 more sources
CTLA-4 expression on tregs is needed for suppression of autoimmune uveitis [PDF]
Scientific ReportsUveitis is a leading cause of blindness in the world and autoimmune uveitis is an ocular tissue specific autoimmune disease. Utilizing experimental autoimmune uveitis (EAU), we can interrogate different immune responses in the mouse that are relevant to ...
Minjun Ahn +3 more
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A novel CTLA-4 deletion variant in a child with refractory autoimmune hemolytic anemia: molecular and functional characterization [PDF]
Frontiers in ImmunologyObjectiveAs a critical immune checkpoint, cytotoxic T-lymphocyte-associated protein 4(CTLA-4)deficiency is a well-established cause of inborn errors of immunity.
Feng Chen +7 more
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A next-generation anti-CTLA-4 probody mitigates toxicity and enhances anti-tumor immunity in mice [PDF]
Nature CommunicationsCTLA-4 is a promising target for immune checkpoint inhibition in cancer therapy, with CTLA-4 blockade achieving prolonged overall survival for responding patients. However, the progressively elevated doses of anti-CTLA-4 agents, aimed at achieving better
Weian Cao +7 more
doaj +2 more sources
Frontiers in Medicine, 2021 Background: Rheumatoid arthritis (RA) is related to several pivotal susceptibility genes, including cytotoxic T-lymphocyte-associated protein 4 (CTLA-4) and costimulatory molecule (CD80/CD86) genes. Although the connection between polymorphisms of CTLA-4
Weixi Liu +7 more
doaj +1 more source
Therapeutic options for CTLA-4 insufficiency
Journal of Allergy and Clinical Immunology, 2022 Heterozygous germline mutations in cytotoxic T lymphocyte-associated antigen-4 (CTLA4) impair the immunomodulatory function of regulatory T cells. Affected individuals are prone to life-threatening autoimmune and lymphoproliferative complications.
Egg, David +75 more
openaire +10 more sources
CTLA-4 CT-60 A/G and CTLA-4 1822 C/T Gene Polymorphisms in Indonesians with Type 1 Diabetes Mellitus [PDF]
, 2022 INTRODUCTION: CTLA-4 gene polymorphism plays an important role in children with type 1 diabetes mellitus (T1DM). However, data on this subject vary among different races and ethnics.
Endaryanto, Anang +11 more
core +1 more source
Identification of CTLA-4-Positive Cells in the Human Tonsil
Cells, 2021 CTLA-4 (cytotoxic T-lymphocyte-associated protein 4) was originally defined as a T-lymphocyte antigen and was used as a target in cancer immunotherapy. Unfortunately, the existence of CTLA-4 in cells other than T-lymphocytes is often overlooked. The goal
Markus Tiemann +3 more
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