Results 11 to 20 of about 12,926,306 (256)

CTLA-4 CT-60 A/G and CTLA-4 1822 C/T Gene Polymorphisms in Indonesians with Type 1 Diabetes Mellitus [PDF]

, 2022
Introduction: CTLA-4 gene polymorphism plays an important role in children with type 1 diabetes mellitus (T1DM). However, data on this subject vary among different races and ethnics.
Nur Rochmah, -, Sukmawati Basuki, -, Anang Endaryanto, -, Retno Asih Setyoningrum, -, Muhammad Faizi, -, Suhasta Nova, -   +5 more
core   +5 more sources

Corresponding CTLA-4 CT-60 A/G and CTLA-4 1822 C/T Gene Polymorphisms in Indonesians with Type 1 Diabetes Mellitus [PDF]

, 2022
Introduction: CTLA-4 gene polymorphism plays an important role in children with type 1 diabetes mellitus (T1DM). However, data on this subject vary among different races and ethnics.
Nur Rochmah, -, Sukmawati Basuki, -, Anang Endaryanto, -, Retno Asih Setyoningrum, -, Muhammad Faizi, -, Suhasta Nova, -   +5 more
core   +1 more source

The CTLA-4 and PD-1/PD-L1 inhibitory pathways independently regulate host resistance to Plasmodium-induced acute immune pathology. [PDF]

, 2012
The balance between pro-inflammatory and regulatory immune responses in determining optimal T cell activation is vital for the successful resolution of microbial infections.
Couper, Kevin N, Claser, C, Riley, Eleanor M, Julius Clemence R Hafalla, Eleanor M Riley, Kevin N Couper, de Souza, J Brian, de Souza, J. Brian, Claser Carla, Renia L., Kevin N. Couper (25399), Grau, GE, Hafalla Julius Clemence R., Laurent Renia (63769), Couper, KN, Hafalla, Julius Clemence R, Grau G.E., Couper Kevin N., Grau, Georges Emile, de Souza, JB, Riley Eleanor M., J. Brian de Souza (25406), Claser C., Renia Laurent, Riley E.M., Hafalla J.C.R., Julius Clemence R. Hafalla (185909), de Souza J.B., de Souza J. Brian, Hafalla, JC, Riley, Eleanor M., Couper K.N., Renia, Laurent, Carla Claser, Georges Emile Grau, Carla Claser (185910), Couper, Kevin N., Georges Emile Grau (185911), Renia, L, Riley, EM, J Brian de Souza, Eleanor M. Riley (25407), Grau Georges Emile, Laurent Renia, Claser, Carla   +44 more
core   +1 more source

CTLA-4 promotes lymphoma progression through tumor stem cell enrichment and immunosuppression

Open Life Sciences, 2021
The recurrence rate of lymphoma is very high, and tumor stem cells may be an important mechanism. Cytotoxic T lymphocyte-associated antigen 4 (CTLA-4) can inhibit antitumor immunity and promote cancer progression, but its role and mechanism in lymphoma ...
Chen Yan, Li Meng, Cao Jian, Cai Guohong, Li Xiantao, Liu Yuejiao, Chen Wen   +6 more
doaj   +1 more source

Comparison of the intracellular trafficking itinerary of ctla-4 orthologues.

PLoS ONE, 2013
CTLA-4 is an essential inhibitor of T cell immune responses. At steady state, most CTLA-4 resides in intracellular compartments due to constitutive internalisation mediated via a tyrosine based endocytic motif (YVKM) within the cytoplasmic domain.
Satdip Kaur, Omar S Qureshi, David M Sansom   +2 more
doaj   +1 more source

CTLA-4 correlates with immune and clinical characteristics of glioma

Cancer Cell International, 2020
Background CTLA-4 is a well-studied immune checkpoint protein that negatively regulates T cell-mediated immune responses. However, the expression of CTLA-4 in glioma and the effects of CTLA-4 on prognosis in patients with glioma have not yet been ...
Fangkun Liu, Jing Huang, Xuming Liu, Quan Cheng, Chengke Luo, Zhixiong Liu   +5 more
doaj   +1 more source

The Role of CTLA-4 in T Cell Exhaustion in Chronic Hepatitis B Virus Infection

Viruses, 2023
Patients with chronic hepatitis B (CHB) gradually develop T cell exhaustion, and the inhibitory receptor molecule, cytotoxic T-lymphocyte antigen-4 (CTLA-4), may play a role in this phenomenon.
Ása Didriksen Apol, Anni Assing Winckelmann, Rasmus Bülow Duus, Jens Bukh, Nina Weis   +4 more
doaj   +1 more source

CTLA4 Message Reflects Pathway Disruption in Monogenic Disorders and Under Therapeutic Blockade

Frontiers in Immunology, 2019
CTLA-4 is essential for immune tolerance. Heterozygous CTLA4 mutations cause immune dysregulation evident in defective regulatory T cells with low levels of CTLA-4 expression.
Josselyn E. Garcia-Perez, Ryan M. Baxter, Daniel S. Kong, Richard Tobin, Martin McCarter, John M. Routes, James Verbsky, Michael B. Jordan, Cullen M. Dutmer, Elena W. Y. Hsieh, Elena W. Y. Hsieh   +10 more
doaj   +1 more source

CTLA-4 polymorphisms and anti-malarial antibodies in a hyper-endemic population of Papua New Guinea [PDF]

, 2008
In malaria endemic areas, people naturally acquire an age-related immunity to malaria. Part of this immunity involves anti-malarial specific antibodies.
Marita Troye-Blomberg, Kenji Hirayama, Mihoko Kikuchi, Hirayama, Kenji, Kaneko, Akira, Hikota Osawa, Anders Björkman, Osawa, Hikota, Akira Kaneko, Kobayakawa, Takatoshi, Bj?rkman, Anders, Udomsangpetch, Rachanee, Kikuchi, Mihoko, Rachanee Udomsangpetch, Hombhanje, Francis, Björkman, Anders, Tanihata, Takeo, Takatoshi Kobayakawa, Francis Hombhanje, Troye-Blomberg, Marita, Takeo Tanihata   +20 more
core   +1 more source

Anti-CTLA-4 antibodies in cancer immunotherapy: selective depletion of intratumoral regulatory T cells or checkpoint blockade?

Cell & Bioscience, 2018
Antibodies to human CTLA-4 have been shown to induce long-lasting protection against melanoma. It is assumed that these antibodies cause tumor rejection by blocking negative signaling from the B7-CTLA-4 interactions to enhance priming of naïve T cells in
Fei Tang, Xuexiang Du, Mingyue Liu, Pan Zheng, Yang Liu   +4 more
doaj   +1 more source