Results 11 to 20 of about 119,169 (307)
Comparison of the intracellular trafficking itinerary of ctla-4 orthologues. [PDF]
PLoS ONE, 2013 CTLA-4 is an essential inhibitor of T cell immune responses. At steady state, most CTLA-4 resides in intracellular compartments due to constitutive internalisation mediated via a tyrosine based endocytic motif (YVKM) within the cytoplasmic domain.
Satdip Kaur +2 more
doaj +6 more sources
Biochemical analysis of CTLA-4 immunoreactive material from human blood [PDF]
BMC Immunology, 2009 Background CTLA-4 was initially described as a membrane-bound molecule that inhibited lymphocyte activation by interacting with B7.1 and B7.2 molecules on antigen presenting cells.
Dennert Kate +4 more
doaj +3 more sources
Structure-Function analysis of the CTLA-4 interaction with PP2A [PDF]
BMC Immunology, 2009 Background CTLA-4 functions primarily as an inhibitor of T cell activation. There are several candidate explanations as to how CTLA-4 modulates T cell responses, but the exact mechanism remains undefined.
Chau Thu A +2 more
doaj +4 more sources
mAbs, 2020 Cytotoxic T-lymphocyte-associated protein 4 (CTLA-4, CD152) is a receptor on T cells that inhibits the cell’s functions. Blocking CTLA-4 with an antibody has proven effective for the treatment of cancer patients. Anti-CTLA-4 antibodies currently approved
Dong Li +3 more
doaj +1 more source
A new mathematical model for the interpretation of translational research evaluating six CTLA-4 polymorphisms in high-risk melanoma patients receiving adjuvant interferon [PDF]
, 2014 Adjuvant therapy of stage IIB/III melanoma with interferon reduces relapse and mortality by up to 33% but is accompanied by toxicity-related complications.
Bafaloukos, D +12 more
core +8 more sources
Immune inhibitory function of bovine CTLA-4 and the effects of its blockade in IFN-γ production
BMC Veterinary Research, 2019 Background Cytotoxic T-lymphocyte antigen 4 (CTLA-4) is known as an immune inhibitory receptor that is expressed on activated effector T cells and regulatory T cells. When CTLA-4 binds to CD80 or CD86, immunoinhibitory signals are transmitted to retain a
Kei Watari +6 more
doaj +1 more source
CTLA-4 promotes lymphoma progression through tumor stem cell enrichment and immunosuppression
Open Life Sciences, 2021 The recurrence rate of lymphoma is very high, and tumor stem cells may be an important mechanism. Cytotoxic T lymphocyte-associated antigen 4 (CTLA-4) can inhibit antitumor immunity and promote cancer progression, but its role and mechanism in lymphoma ...
Chen Yan +6 more
doaj +1 more source
No association of CTLA-4 polymorphisms with susceptibility to Behcet disease [PDF]
, 2009 Background: Cytotoxic T lymphocyte-associated antigen 4 (CTLA-4) is a key negative regulator of T lymphocytes and has been shown to be associated with a number of autoimmune diseases. The present study was performed to assess the association between CTLA-
Du, L. +4 more
core +2 more sources
médecine/sciences, 2011 L’immunotherapie par anticorps anti-CTLA-4, ipilimumab, est un traitement efficace du melanome metastatique utilise en monotherapie ou associe a la chimiotherapie (dacarbazine). L’effet therapeutique ne s’observe que chez 10 % a 20 % des patients, mais c’est la premiere fois qu’un medicament a un effet benefique sur la survie globale dans ce contexte ...
Caroline Robert, Christine Mateus
openaire +1 more source
CTLA-4 correlates with immune and clinical characteristics of glioma
Cancer Cell International, 2020 Background CTLA-4 is a well-studied immune checkpoint protein that negatively regulates T cell-mediated immune responses. However, the expression of CTLA-4 in glioma and the effects of CTLA-4 on prognosis in patients with glioma have not yet been ...
Fangkun Liu +5 more
doaj +1 more source