Results 41 to 50 of about 119,169 (307)
Frontiers in Immunology, 2019 The present study evaluated the impact of blocking cytotoxic T-lymphocyte antigen-4 (CTLA-4) activity on the protective effect elicited by the fatty acid binding protein (FABP) vaccine against Schistosoma japonicum infection.
Chun-lian Tang +5 more
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Beyond T-Cells: Functional Characterization of CTLA-4 Expression in Immune and Non-Immune Cell Types
Frontiers in Immunology, 2020 The immune response consists of a finely-tuned program, the activation of which must be coupled with inhibitory mechanisms whenever initiated. This ensures tight control of beneficial anti-pathogen and anti-tumor responses while preserving tissue ...
Damilola Oyewole-Said +9 more
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Polymorphic sites at the immunoregulatory CTLA-4 gene are associated with chronic chagas disease and its clinical manifestations. [PDF]
PLoS ONE, 2013 BACKGROUND:Chagas disease affects approximately 10 million people mainly in Latin America. The immune regulation by the host seems to be an essential factor for disease evolution, and immune system inhibitory molecules such as CTLA-4 and PD-1 favor the ...
Fabrício C Dias +11 more
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Cytotoxic T lymphocyte antigen-4 (CTLA-4) A49G polymorphism and autoimmune blood diseases [PDF]
, 2010 Objective: The cytotoxic T lymphocyte associated antigen-4 (CTLA-4) is expressed on T lymphocytes, and inhibits the T-cell responses. In animal models, it has been shown that complete CTLA-4 deficiency was lethal due to massive infiltration of tissues by
Faruk Aktürk +2 more
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برهمکنش های مولکولی بین CTLA-4 و CD80/CD86 در تنظیم پاسخ های ایمنی: مقاله مروری [PDF]
Majallah-i Dānishkadah-i Pizishkī-i Dānishgāh-i ̒ Ulūm-i Pizishkī-i Mashhad.یکی از اصلی ترین مکانیسم های تنظیم پاسخ های ایمنی برهم کنش متقابل CTLA-4 و CD80/CD86 است. CTLA-4 نوعی رسپتور مهاری و دارای لیگاندهای CD80/CD86 و مشترک با گیرنده کمک محرک CD28 است. CTLA-4 طی فرآیندی به نام ترانس اندوسیتوزیس این لیگاندها را اندوسیتوز کرده
زهرا درویش خلیل آبادی +2 more
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Frontiers in Immunology, 2020 CD80 and CD86 are expressed on antigen presenting cells and are required to engage their shared receptor, CD28, for the costimulation of CD4 T cells. It is unclear why two stimulatory ligands with overlapping roles have evolved.
Neil Halliday +12 more
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Augmentation of CTLA-4 expression by wortmannin: involvement of lysosomal sorting properties of CTLA-4 [PDF]
International Immunology, 1999 CTLA-4 (CD152) is transiently induced on the cell surface of activated T cells and expression is limited at a low level. In this study, we investigated the possibility that phosphatidylinositol 3 kinase (PI 3-K) and other related PI kinases associated with the cytoplasmic domain of CTLA-4 are involved in intracellular trafficking and sorting of CTLA-4 ...
S, Oki, T, Kohsaka, M, Azuma
openaire +2 more sources
Immune checkpoint deficiencies and autoimmune lymphoproliferative syndromes
Biomedical Journal, 2021 Autoimmune lymphoproliferative syndrome (ALPS) is an inherited non-malignant and non-infectious lymphoproliferative syndrome caused by mutations in genes affecting the extrinsic apoptotic pathway (FAS, FASL, CASP10).
Laura Gámez-Díaz, Bodo Grimbacher
doaj +1 more source
CTLA-4: From conflict to clinic [PDF]
The Journal of Experimental Medicine, 2007 CTLA-4 was first identified in 1991 as a second receptor for the T cell costimulation ligand B7. Uncertainties about its biological function plagued the early years after its discovery until 1995, when it was confirmed to be an inhibitor of T cell responses.
openaire +2 more sources
Immunoregulatory soluble CTLA-4 modifies effector T cell responses in systemic lupus erythematosus [PDF]
, 2016 Acknowledgments This work was supported by Arthritis Research UK (Grant no. 19282). We are grateful to Dr. Nick Fluck for his invaluable support in recruiting patients for the study, and Mrs.
Barker, Robert N. +6 more
core +3 more sources