Results 41 to 50 of about 22,609,350 (346)
Developing and characterizing a single-domain antibody (nanobody) against human cytotoxic T-lymphocyte-associated protein 4 (hCTLA-4) [PDF]
Iranian Journal of Basic Medical Sciences, 2021 Objective(s): Cytotoxic T-lymphocyte-associated protein-4 (CTLA-4) is the most important human immune checkpoint that modulates T cells activity and brings about immune-homeostasis.
Nazli Sotoudeh +4 more
doaj +1 more source
Expression of CTLA‐4 by Human Monocytes [PDF]
Scandinavian Journal of Immunology, 2002 Cytotoxic T lymphocyte‐associated molecule‐4 (CTLA‐4) is a receptor present on T cells that plays a critical role in the downregulation of antigen‐activated immune responses. CTLA‐4 interacts with the ligands CD80 and CD86 on antigen‐presenting cells (APC), and also directs the assembly of inhibitory signalling complexes that lead to quiescence or ...
X-B, Wang +5 more
openaire +2 more sources
Progress in Research on Cytotoxic T Lymphocyte-Associated Antigen 4 (CTLA-4) and Bladder Cancer
Annals of Urologic Oncology, 2019 Cytotoxic T-lymphocyte-associated protein-4 (CTLA-4) was first discovered in 1987 and confirmed to be a protein that is mainly expressed on the surface of activated lymphocytes.
Wei-Ming Fang, Chun Chen
doaj +1 more source
Journal of Experimental Medicine, 2013 Anti–CTLA-4 antibody induces selective depletion of T reg cells within tumor lesions in a manner that is dependent on the presence of Fc gamma receptor-expressing macrophages within the tumor microenvironment.
T. Simpson +13 more
semanticscholar +1 more source
A MOLECULAR PERSPECTIVE OF CTLA-4 FUNCTION
Annual Review of Immunology, 2006 Within the paradigm of the two-signal model of lymphocyte activation, the interest in costimulation has witnessed a remarkable emergence in the past few years with the discovery of a large array of molecules that can serve this role, including some with an inhibitory function.
Teft, Wendy A. +2 more
openaire +3 more sources
CTLA-4 trafficking and surface expression [PDF]
Trends in Immunology, 2008 The T-cell co-receptor cytotoxic T-cell antigen 4 (CTLA-4) has a strong inhibitory role as shown by the lymphoproliferative phenotype of CTLA-4-deficient mice. Despite its potent effects on T-cell function, CTLA-4 is primarily an intracellular antigen whose surface expression is tightly regulated by restricted trafficking to the cell surface and rapid ...
Elke, Valk +2 more
openaire +2 more sources
Trans-endocytosis of CD80 and CD86: a molecular basis for the cell extrinsic function of CTLA-4
Science, 2011 An inhibitory T cell receptor acts by stripping activating ligands off dendritic cells. Cytotoxic T lymphocyte antigen 4 (CTLA-4) is an essential negative regulator of T cell immune responses whose mechanism of action is the subject of debate.
O. Qureshi +14 more
semanticscholar +1 more source
Proceedings of the National Academy of Sciences of the United States of America, 2021 Significance Immunosuppressive Tregs constitutively express CTLA-4, an immune checkpoint receptor. Addressing the role of CTLA-4 in Treg-suppressive function, we show that Treg-expressed CTLA-4, even in the absence of its cytoplasmic portion, promoted ...
Murat Tekguc +4 more
semanticscholar +1 more source
CTLA-4: Not All Costimulation Is Stimulatory [PDF]
The Journal of Immunology, 2011 To activate a T cell, it was widely accepted, even in the 1960s, that there had to be a “signal one,” namely, receptor recognition of a foreign Ag. That fact did not make it less exciting when, in the early 1980s, Abs to the TCR were generated and the genes that encode it identified ([1][1 ...
Hugh, Auchincloss, Laurence A, Turka
openaire +2 more sources
, 2023 Cytotoxic T lymphocyte-associated protein 4 (CTLA-4) is an immune checkpoint regulator exclusively expressed on T cells that obstructs the cell’s effector functions.
Richard Strasser +17 more
core +1 more source