Results 61 to 70 of about 12,926,306 (256)

Supplementary Figure S6: Ipilimumab does not deplete CD4+CTLA-4+FOXP3+ Tregs from Anti-CTLA-4 Immunotherapy Does Not Deplete FOXP3⁺ Regulatory T Cells (Tregs) in Human Cancers

, 2019
Tumor infiltrating cells from paired melanoma tissue (N=5 pre-Ipi; N=5 post-Ipi) were analyzed by CyTOF. The impact of ipilimumab on the intratumoral frequency of A) CD3+CD4+FOXP3+CTLA-4+ (Tregs), B) CD3+CD4+FOXP3-CTLA-4+ T cells, and C) CD3+CD4+FOXP3 ...
Padmanee Sharma (8133285), Jorge Blando (8133276), Jennifer Wargo (3536045), Jorge Scutti (15010292), James P. Allison (15010295), Antoni Ribas (49231), Anu Sharma (4976), Sumit K. Subudhi (14992022), Luis Vence (312988)   +8 more
core   +1 more source

Supplementary Data from Microneedle-mediated Intratumoral Delivery of Anti-CTLA-4 Promotes cDC1-dependent Eradication of Oral Squamous Cell Carcinoma with Limited irAEs

, 2022
Supplementary Data from Microneedle-mediated Intratumoral Delivery of Anti-CTLA-4 Promotes cDC1-dependent Eradication of Oral Squamous Cell Carcinoma with Limited ...
Andrew Sharabi (3158010), Marco Proietto (516502), Fernando Soto (1424989), Dana J. Ramms (15089490), Zhiyong Wang (14937261), Zbigniew Mikulski (15089493), J. Silvio Gutkind (90145), Ricardo Rueda (15089499), Victoria H. Wu (14937258), Miguel Angel Lopez-Ramirez (1386993), Daniel Kupor (15089496), Mara Gilardi (14938508), Joseph Wang (363503), Daniel P. Hollern (4778604), Robert Saddawi-Konefka (15027759), Haruka Miki (3621107)   +15 more
core   +1 more source

Single‐Dose TACE‐Like Injection of Sustained‐Release Panobinostat/IL‐12 Polymeric Microparticles is Effective in Preclinical Liver Cancer Models

Advanced Science, EarlyView.
A novel PLGA/PBAE polymer microparticle platform revolutionizes intermediate‐stage liver cancer treatment by co‐delivering panobinostat and IL‐12 via a single TACE‐like injection. This sustained‐release system overcomes tumor immunosuppression, triggers robust innate and adaptive immune responses, and establishes tertiary lymphoid structures ...
Hongzhe Yu, Ling Li, Sachin S. Surwase, Xin Ming M. Zhou, Hongtao Qian, Joel C. Sunshine, Florin M. Selaru, Jordan J. Green   +7 more
wiley   +1 more source

Rigid, bivalent CTLA-4 binding to CD80 is required to disrupt the cis CD80/PD-L1 interaction

Cell Reports
Summary: The CTLA-4 and PD-1 checkpoints control immune responses and are key targets in immunotherapy. Both pathways are connected via a cis interaction between CD80 and PD-L1, the ligands for CTLA-4 and PD-1, respectively. This cis interaction prevents
Maximillian A. Robinson, Alan Kennedy, Carolina T. Orozco, Hung-Chang Chen, Erin Waters, Dalisay Giovacchini, Kay Yeung, Lily Filer, Claudia Hinze, Christopher Lloyd, Simon J. Dovedi, David M. Sansom   +11 more
doaj   +1 more source

Evolving Roles for Targeting CTLA-4 in Cancer Immunotherapy

Cellular Physiology and Biochemistry, 2018
Cytotoxic T lymphocyte-associated antigen-4 (CTLA-4) is a membrane glycoprotein expressed by activated effector T cells (Teffs) and participates in the repression of T cell proliferation, cell cycle progression and cytokine production.
Yinghao Zhao, Wei Yang, Yuanyuan Huang, Ranji Cui, Xiangyan Li, Bingjin Li   +5 more
doaj   +1 more source

Related Article from Intratumoral Anti-CTLA-4 Therapy: Enhancing Efficacy While Avoiding Toxicity

, 2013
Related Article from Intratumoral Anti-CTLA-4 Therapy: Enhancing Efficacy While Avoiding ...
Holbrook Kohrt (3541958), Aurélien Marabelle (596847), Ronald Levy (25981)   +2 more
core   +1 more source

CTLA-4 gene polymorphisms are associated with obesity in Turner syndrome [PDF]

, 2018
Turner syndrome (TS) is characterized by a set of clinical conditions, including autoimmune/inflammatory diseases and infectious conditions, that can compromise a patient's quality of life.
Sergio Crovella (290351), Taciana Furtado de Mendonça Belmont (3108180), Adriana Valéria Sales Bispo, Rafaella do Nascimento Pinto (6048923), Raysa Samanta Moraes Laranjeira (6048920), Andréa de Rezende Duarte (6048929), Paula Sandrin-Garcia (4499488), Maria do Socorro Cavalcanti, Taciana Furtado de Mendonça Belmont, Maria do Socorro Cavalcanti (6048935), Cavalcanti, Maria Do Socorro, Jaqueline de Azevêdo Silva, Pinto, Rafaella do Nascimento, Juliana Vieira de Barros (6048917), dos Santos, Luana Oliveira, Neide Santos (6048938), Adriana Valéria Sales Bispo (6048914), Laranjeira, Raysa Samanta Moraes, Luana Oliveira dos Santos, Crovella, Sergio, Duarte, Andréa de Rezende, Andréa de Rezende Duarte, Jacqueline Araújo, Marcos André Cavalcanti Bezerra (3108192), Neide Santos, Bispo, Adriana Valéria Sales, Jaqueline de Azevêdo Silva (6048926), Raysa Samanta Moraes Laranjeira, Sandrin-Garcia, Paula, Bezerra, Marcos André Cavalcanti, Silva, Jaqueline de Azevêdo, Luana Oliveira dos Santos (6048911), Sergio Crovella, Paula Sandrin-Garcia, Santos, Neide, Marcos André Cavalcanti Bezerra, de Barros, Juliana Vieira, Jacqueline Araújo (6048932), Juliana Vieira de Barros, Rafaella do Nascimento Pinto, Araújo, Jacqueline, Belmont, Taciana Furtado de Mendonça   +41 more
core   +1 more source

Macrophage PABPC4‐SPP1 Axis Orchestrates Immunosuppression in Colorectal Cancer

Advanced Science, EarlyView.
In the CRC microenvironment, macrophage PABPC4 binds to the 3′UTR of SPP1 mRNA to stabilize its expression, thereby sustaining M2‐like immunosuppressive macrophage polarization. Concurrently, this axis suppresses CD8+ T cell effector functions via CD44 signaling, collectively fostering an immunosuppressive niche that drives tumor progression.
Meng Wang, Fang Yang, Yuan Gao, Liuli Li, Yulan Huang, Hui Yao, Sijie Zhao, Kun Zhao, Tianying Zhang, Hui Heng, Jiaxin Xu, Yuancai Xiang, Weidong Xiao, Shaofan Hu, Hongming Miao   +14 more
wiley   +1 more source

Correlation Between IFNγ+ and CTLA-4+ Tumor Infiltrating Lymphocytes In Luminal And Non-Luminal Breast Carcinoma

Qanun Medika: Jurnal Kedokteran Fakultas Kedokteran Universitas Muhammadiyah Surabaya, 2019
The role of tumor infiltrating lymphocytes (TIL) in breast carcinoma depends on the molecular subtype, especially the expression of the estrogen receptor.
Irene Lingkan Parengkuan, Sjahjenny Mustokoweni, Nila Kurniasari   +2 more
doaj   +1 more source

CTLA-4 expression, regulation and associations in autoimmune myasthenia gravis

, 2003
Myasthenia gravis (MG) is a neuromuscular disease with muscle weakness due to an autoimmune attack against the nicotinic acetylcholine receptor (nAChR) on the skeletal muscle endplate.
XiongBiao Wang (19494277)
core   +1 more source