Results 71 to 80 of about 22,609,350 (346)

Combination of CTLA-4 and PD-1 blockers for treatment of cancer

Journal of experimental & clinical cancer research : CR, 2019
Targeting checkpoints of immune cell activation has been demonstrated to be the most effective approach for activation of anti-tumor immune responses. Cytotoxic T-lymphocyte-associated protein 4 (CTLA-4) and programmed cell death protein 1 (PD-1), both ...
Anand Rotte
semanticscholar   +1 more source

CTLA-4

, 2019
ALPSOY, ERKAN/0000-0001-7049-0170; uzun, soner/0000-0001-7059-5474; gunasti topal, suhan/0000-0003-0467-5884;
Bacanli, Ali, Karakas, Ayse Akman, Sallakci, Nilgun, Topal, Suhan Gunasti, Aydin, Fatma, Uzun, Soner, Alpsoy, Erkan   +6 more
openaire   +2 more sources

CD47 promotes mitogen‐activated protein kinase and epithelial‐to‐mesenchymal transition molecular programs to drive prometastatic phenotypes in non‐small cell lung cancer

Molecular Oncology, EarlyView.
Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau, Lilian G. Zhai, Ryunosuke Hoshi, Zackary Rousseau, Abraam Zakhary, Yin Fang Wu, Rola M. Saleeb, Heyu Ni, Kelsie L. Thu   +8 more
wiley   +1 more source

Biochemical analysis of CTLA-4 immunoreactive material from human blood

BMC Immunology, 2009
Background CTLA-4 was initially described as a membrane-bound molecule that inhibited lymphocyte activation by interacting with B7.1 and B7.2 molecules on antigen presenting cells.
Dennert Kate, Kozinski Karen, Khatri Bhupendra O, Tector Matt, Oaks Martin K   +4 more
doaj   +1 more source

Prior anti-CTLA-4 therapy impacts molecular characteristics associated with anti-PD-1 response in advanced melanoma

Cancer Cell, 2023
Summary Immune checkpoint inhibitors (ICIs), including CTLA-4 and PD-1 blocking antibodies, can have profound effects on tumor immune cell infiltration that have not been consistent in biopsy series reported to date.
Katie M. Campbell, M. Amouzgar, Shannon M. Pfeiffer, Tim Howes, Egmidio Medina, M. Travers, Gabriela Steiner, J. Weber, J. Wolchok, J. Larkin, F. Hodi, S. Boffo, Lisa Salvador, D. Tenney, Tracy Tang, Marshall A. Thompson, Christine N. Spencer, Daniel K. Wells, A. Ribas   +18 more
semanticscholar   +1 more source

Immune Checkpoint Inhibitor–Related Myositis and Associated Triad Overlap Syndrome

Arthritis Care &Research, EarlyView.
Objective Immune checkpoint inhibitor (ICI) myositis is a rare but a highly morbid condition, particularly with the ICI myositis triad syndrome of myositis, myocarditis, and myasthenia gravis. We report the clinical characteristics of ICI myositis and all‐cause mortality in these patients.
Selene Rubino, Grant W. Cannon, Brian C. Sauer, Jorge Rojas, Gregory J. Stoddard, Gary A. Kunkel, Jessica A. Walsh, Bryant R. England, Joshua F. Baker, Tawnie J. Braaten   +9 more
wiley   +1 more source

Expression of immune checkpoint regulators, cytotoxic T lymphocyte antigen 4 (CTLA-4) and programmed death-ligand 1 (PD-L1), in female breast carcinomas. [PDF]

PLoS ONE, 2018
Immune checkpoint regulators, cytotoxic T lymphocyte antigen 4 (CTLA-4) and the programmed cell death protein-1/programmed death-ligand 1 (PD-1/PD-L1) have emerged as promising new targets for cancer therapeutics. While tumor expression of PD-L1 has been
Ari Kassardjian, Peter I Shintaku, Neda A Moatamed   +2 more
doaj   +1 more source

Different Apples, Same Tree: Visualizing Current Biological and Clinical Insights into CTLA-4 Insufficiency and LRBA and DEF6 Deficiencies

Frontiers in Pediatrics, 2021
Cytotoxic T lymphocyte antigen-4 (CTLA-4) is a crucial immune checkpoint that is constitutively expressed in regulatory T (Treg) cells. Following T-cell activation, CTLA-4 is rapidly mobilized from its intracellular vesicle pool to the cell surface to ...
Laura Gámez-Díaz, Markus G. Seidel, Markus G. Seidel   +2 more
doaj   +1 more source

Differences in CD80 and CD86 transendocytosis reveal CD86 as a key target for CTLA-4 immune regulation

Nature Immunology, 2022
CD28 and CTLA-4 (CD152) play essential roles in regulating T cell immunity, balancing the activation and inhibition of T cell responses, respectively.
A. Kennedy, E. Waters, Behzad Rowshanravan, C. Hinze, C. Williams, D. Janman, T. Fox, C. Booth, Anne M. Pesenacker, Neil Halliday, B. Soskic, S. Kaur, O. Qureshi, E. C. Morris, S. Ikemizu, C. Paluch, J. Huo, S. Davis, Emmanuel Boucrot, L. Walker, D. Sansom   +20 more
semanticscholar   +1 more source

CTLA-4 gene polymorphisms are associated with obesity in Turner syndrome [PDF]

, 2018
Turner syndrome (TS) is characterized by a set of clinical conditions, including autoimmune/inflammatory diseases and infectious conditions, that can compromise a patient's quality of life.
Sergio Crovella (290351), Taciana Furtado de Mendonça Belmont (3108180), Adriana Valéria Sales Bispo, Rafaella do Nascimento Pinto (6048923), Raysa Samanta Moraes Laranjeira (6048920), Andréa de Rezende Duarte (6048929), Paula Sandrin-Garcia (4499488), Maria do Socorro Cavalcanti, Taciana Furtado de Mendonça Belmont, Maria do Socorro Cavalcanti (6048935), Cavalcanti, Maria Do Socorro, Jaqueline de Azevêdo Silva, Pinto, Rafaella do Nascimento, Juliana Vieira de Barros (6048917), dos Santos, Luana Oliveira, Neide Santos (6048938), Adriana Valéria Sales Bispo (6048914), Laranjeira, Raysa Samanta Moraes, Luana Oliveira dos Santos, Crovella, Sergio, Duarte, Andréa de Rezende, Andréa de Rezende Duarte, Jacqueline Araújo, Marcos André Cavalcanti Bezerra (3108192), Neide Santos, Bispo, Adriana Valéria Sales, Jaqueline de Azevêdo Silva (6048926), Raysa Samanta Moraes Laranjeira, Sandrin-Garcia, Paula, Bezerra, Marcos André Cavalcanti, Silva, Jaqueline de Azevêdo, Luana Oliveira dos Santos (6048911), Sergio Crovella, Paula Sandrin-Garcia, Santos, Neide, Marcos André Cavalcanti Bezerra, de Barros, Juliana Vieira, Jacqueline Araújo (6048932), Juliana Vieira de Barros, Rafaella do Nascimento Pinto, Araújo, Jacqueline, Belmont, Taciana Furtado de Mendonça   +41 more
core   +1 more source