Results 31 to 40 of about 12,926,306 (256)
CTLA-4 Antibodies in Cancer Immunotherapy
, 2016 Activating human immune system to battle cancer has been a focus of cancer immunotherapy research from quite some time. After decades of disappointment, the tide has finally changed with some recent successes in clinical trials.
Veerendra Koppolu (3073263)
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1) Investigation of the clathrin-dependent internalisation of Cytotoxic T Lymphocyte Antigen-4 2) Analysis of the antigen-specific cytokine responses of CD4+ T lymphocytes [PDF]
, 2011 1) Cytotoxic T Lymphocyte Antigen-4 (CTLA-4) is a key inhibitory regulator of T-cell function. Its expression is predominantly intracellular however, many theories surrounding it’s inhibitory action do not account for its endocytic behaviour.
Voice, Marie Ann
core +6 more sources
Frontiers in Immunology, 2019 The present study evaluated the impact of blocking cytotoxic T-lymphocyte antigen-4 (CTLA-4) activity on the protective effect elicited by the fatty acid binding protein (FABP) vaccine against Schistosoma japonicum infection.
Chun-lian Tang +5 more
doaj +1 more source
Polymorphic sites at the immunoregulatory CTLA-4 gene are associated with chronic chagas disease and its clinical manifestations. [PDF]
PLoS ONE, 2013 BACKGROUND:Chagas disease affects approximately 10 million people mainly in Latin America. The immune regulation by the host seems to be an essential factor for disease evolution, and immune system inhibitory molecules such as CTLA-4 and PD-1 favor the ...
Fabrício C Dias +11 more
doaj +1 more source
, 2011 T cells play a critical role in alloimmune recognition and thus contribute to graft-versus-host disease (GVHD) and relapse prevention in hematopoietic stem cell transplantation (HSCT). Cytotoxic T lymphocyte antigen-4 ( CTLA-4) and inducible costimulator
WU, JUI;TANG, JIH-LUH;WU, SHANG-JU;YANG, YA -CHIEN;YANG, YA-CHIEN +1 more
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برهمکنش های مولکولی بین CTLA-4 و CD80/CD86 در تنظیم پاسخ های ایمنی: مقاله مروری [PDF]
Majallah-i Dānishkadah-i Pizishkī-i Dānishgāh-i ̒ Ulūm-i Pizishkī-i Mashhad.یکی از اصلی ترین مکانیسم های تنظیم پاسخ های ایمنی برهم کنش متقابل CTLA-4 و CD80/CD86 است. CTLA-4 نوعی رسپتور مهاری و دارای لیگاندهای CD80/CD86 و مشترک با گیرنده کمک محرک CD28 است. CTLA-4 طی فرآیندی به نام ترانس اندوسیتوزیس این لیگاندها را اندوسیتوز کرده
زهرا درویش خلیل آبادی +2 more
doaj +1 more source
Frontiers in Immunology, 2020 CD80 and CD86 are expressed on antigen presenting cells and are required to engage their shared receptor, CD28, for the costimulation of CD4 T cells. It is unclear why two stimulatory ligands with overlapping roles have evolved.
Neil Halliday +12 more
doaj +1 more source
Immune checkpoint deficiencies and autoimmune lymphoproliferative syndromes
Biomedical Journal, 2021 Autoimmune lymphoproliferative syndrome (ALPS) is an inherited non-malignant and non-infectious lymphoproliferative syndrome caused by mutations in genes affecting the extrinsic apoptotic pathway (FAS, FASL, CASP10).
Laura Gámez-Díaz, Bodo Grimbacher
doaj +1 more source
No evidence of a significant role for CTLA-4 in multiple sclerosis [PDF]
, 2006 Variation in the cytotoxic T-lymphocyte-associated protein 4 (CTLA-4) gene plays a significant role in determining susceptibility to autoimmune thyroid disease and type 1 diabetes. Its role in multiple sclerosis is more controversial. In order to explore
Maranian, M +7 more
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Molecular Oncology, EarlyView.High‐risk bladder cancer is typically treated with Bacillus Calmette‐Guérin (BCG), but 30–40% of patients relapse. No FDA‐ or CE‐approved biomarkers currently predict or prognosticate BCG failure. We systematically reviewed the literature and identified 72 eligible studies, revealing several promising biomarkers associated with BCG treatment response ...
Rui Ribeiro‐Pereira +7 more
wiley +1 more source