Results 31 to 40 of about 22,609,350 (346)

The Role of CTLA-4 in T Cell Exhaustion in Chronic Hepatitis B Virus Infection

Viruses, 2023
Patients with chronic hepatitis B (CHB) gradually develop T cell exhaustion, and the inhibitory receptor molecule, cytotoxic T-lymphocyte antigen-4 (CTLA-4), may play a role in this phenomenon.
Ása Didriksen Apol, Anni Assing Winckelmann, Rasmus Bülow Duus, Jens Bukh, Nina Weis   +4 more
doaj   +1 more source

Corresponding CTLA-4 CT-60 A/G and CTLA-4 1822 C/T Gene Polymorphisms in Indonesians with Type 1 Diabetes Mellitus [PDF]

, 2022
Introduction: CTLA-4 gene polymorphism plays an important role in children with type 1 diabetes mellitus (T1DM). However, data on this subject vary among different races and ethnics.
Nur Rochmah, -, Sukmawati Basuki, -, Anang Endaryanto, -, Retno Asih Setyoningrum, -, Muhammad Faizi, -, Suhasta Nova, -   +5 more
core  

CTLA-4 correlates with immune and clinical characteristics of glioma

Cancer Cell International, 2020
Background CTLA-4 is a well-studied immune checkpoint protein that negatively regulates T cell-mediated immune responses. However, the expression of CTLA-4 in glioma and the effects of CTLA-4 on prognosis in patients with glioma have not yet been ...
Fangkun Liu, Jing Huang, Xuming Liu, Quan Cheng, Chengke Luo, Zhixiong Liu   +5 more
doaj   +1 more source

Genomic correlates of response to CTLA-4 blockade in metastatic melanoma

Science, 2015
Is cancer immunotherapy a private affair? Immune checkpoint blockade, a relatively new cancer treatment, substantially extends the survival of a subset of patients. Previous work has shown that patients whose tumors harbor the largest number of mutations—
E. V. Van Allen, Diana Miao, B. Schilling, S. Shukla, C. Blank, L. Zimmer, A. Sucker, U. Hillen, M. G. Geukes Foppen, S. Goldinger, J. Utikal, J. Hassel, B. Weide, K. Kaehler, C. Loquai, P. Mohr, R. Gutzmer, R. Dummer, S. Gabriel, Catherine J. Wu, D. Schadendorf, L. Garraway   +21 more
semanticscholar   +1 more source

CTLA-4 polymorphisms and anti-malarial antibodies in a hyper-endemic population of Papua New Guinea [PDF]

, 2008
In malaria endemic areas, people naturally acquire an age-related immunity to malaria. Part of this immunity involves anti-malarial specific antibodies.
Marita Troye-Blomberg, Kenji Hirayama, Mihoko Kikuchi, Hirayama, Kenji, Kaneko, Akira, Hikota Osawa, Anders Björkman, Osawa, Hikota, Akira Kaneko, Kobayakawa, Takatoshi, Bj?rkman, Anders, Udomsangpetch, Rachanee, Kikuchi, Mihoko, Rachanee Udomsangpetch, Hombhanje, Francis, Björkman, Anders, Tanihata, Takeo, Takatoshi Kobayakawa, Francis Hombhanje, Troye-Blomberg, Marita, Takeo Tanihata   +20 more
core   +1 more source

CTLA4 Message Reflects Pathway Disruption in Monogenic Disorders and Under Therapeutic Blockade

Frontiers in Immunology, 2019
CTLA-4 is essential for immune tolerance. Heterozygous CTLA4 mutations cause immune dysregulation evident in defective regulatory T cells with low levels of CTLA-4 expression.
Josselyn E. Garcia-Perez, Ryan M. Baxter, Daniel S. Kong, Richard Tobin, Martin McCarter, John M. Routes, James Verbsky, Michael B. Jordan, Cullen M. Dutmer, Elena W. Y. Hsieh, Elena W. Y. Hsieh   +10 more
doaj   +1 more source

CTLA-4 and PD-1 Pathways

American Journal of Clinical Oncology, 2016
The cytotoxic T-lymphocyte–associated antigen 4 (CTLA-4) and programmed death 1 (PD-1) immune checkpoints are negative regulators of T-cell immune function.
E. Buchbinder, Anupam M. Desai
semanticscholar   +1 more source

The price of tumor control: an analysis of rare side effects of anti-CTLA-4 therapy in metastatic melanoma from the ipilimumab network [PDF]

, 2013
Background: Ipilimumab, a cytotoxic T-lymphocyte antigen-4 (CTLA-4) blocking antibody, has been approved for the treatment of metastatic melanoma and induces adverse events (AE) in up to 64% of patients.
Berking, Carola, Armin Justich (103646), Simone M. Goldinger, Daniela Göppner, Lucie M Heinzerling, Stephan Grabbe (103633), Clemens L. Bockmeyer, Robert Caroline, Thomas Eigentler, Christine Mateus (103663), Moos, Roger von, Loquai Carmen, Gerold Schuler, Dirk Schadendorf (103684), Christina Klein, Pätzold, Sylvie, Hundorfean, Gheorghe, Beatrice Schuler-Thurner, Göppner Daniela, Ralf Gutzmer (103628), Patrik Weder, Robert, Caroline, Bockmeyer, Clemens L., Dirk Schadendorf, Kaehler, Katharina C., Thomas Eigentler (103619), Katharina C. Kaehler, Gheorghe Hundorfean, Christine Mateus, Simone M. Goldinger (103594), Claus Garbe, Satzger, Imke, Ralf Gutzmer, Sylvie Paetzold (103676), Peter Mohr, Uwe Trefzer, Voskens, Caroline J, Carmen Loquai (103597), Bockmeyer Clemens L., Vaubel, Julia, Jens Ulrich, Wilhelm, Tabea, Bockmeyer, Clemens Luitpold, Julia Vaubel, Hauschild Axel, Mohr, Peter, Gheorghe Hundorfean (103642), Caroline J. Voskens, Justich, Armin, Hauschild, Axel, Fluck Michael, Loquai, Carmen, Schadendorf, Dirk, Beatrice Schuler-Thurner (103693), Satzger Imke, Göppner, Daniela, Carola Berking, Weder Patrik, Hundorfean Gheorghe, Eigentler, Thomas Kurt, Grabbe, Stephan, Ulrich Jens, Armin Justich, Rüdiger Hein (71354), Garbe Claus, Ulrich, Jens, Eigentler Thomas, Schadendorf Dirk, Gutzmer Ralf, Mateus Christine, Imke Satzger, Weder, Patrik, Ullrich Keller (103650), Lucie M. Heinzerling (103723), Gerold Schuler (103690), Axel Hauschild (103637), Christina Klein (103657), Michael Fluck, Tanja Bergmann (103612), Axel Hauschild, Paetzold Sylvie, Katharina C Kaehler, Wilhelm Tabea, Keller, Ullrich, Schlaeppi Marc, Goldinger, Simone M., Claus Garbe (48881), Berking Carola, Heinzerling, Lucie, von Moos Roger, Simone M Goldinger, Trefzer Uwe, Uwe Trefzer (72075), Rüdiger Hein, Mateus, Christine, Caroline Robert, Tabea Wilhelm (103712), Schuler Gerold, Dummer, Reinhard, Schuler-Thurner Beatrice, Roger von Moos, Hein Rüdiger, Eigentler, Thomas, Paetzold, Sylvie, Caroline J Voskens, Caroline J. Voskens (103590), Schuler-Thurner, Beatrice, Roger von Moos (103705), Patrik Weder (103709), Lucie M. Heinzerling, Kaehler, Katharina C, Voskens, Caroline J., Fluck, Michael, Imke Satzger (103681), Schuler, Gerold, Tanja Bergmann, Marc Schlaeppi (103687), Bergmann, Tanja Regina, Julia Vaubel (103700), Bergmann Tanja, Heinzerling, Lucie M., Stephan Grabbe, Klein Christina, Caroline Robert (103600), Carola Berking (103608), Kähler, Katharina C., Peter Mohr (103669), Klein, Christina, Tabea Wilhelm, Reinhard Dummer (103718), Goldinger Simone M., Reinhard Dummer, Marc Schlaeppi, Gutzmer, Ralf, Hein, Rüdiger, Clemens L Bockmeyer, Sylvie Paetzold, Michael Fluck (103622), Kaehler Katharina C., Justich Armin, Voskens Caroline J., Carmen Loquai, Vaubel Julia, Grabbe Stephan, Keller Ullrich, Mohr Peter, Jens Ulrich (103696), Trefzer, Uwe, Katharina C. Kaehler (103604), Bergmann, Tanja, Heinzerling Lucie M., Dummer Reinhard, et al, Goldinger, Simone M, Daniela Göppner (103715), Garbe, Claus, Clemens L. Bockmeyer (103616), Schlaeppi, Marc, Ullrich Keller   +158 more
core   +1 more source

Anti-CTLA-4 antibodies in cancer immunotherapy: selective depletion of intratumoral regulatory T cells or checkpoint blockade?

Cell & Bioscience, 2018
Antibodies to human CTLA-4 have been shown to induce long-lasting protection against melanoma. It is assumed that these antibodies cause tumor rejection by blocking negative signaling from the B7-CTLA-4 interactions to enhance priming of naïve T cells in
Fei Tang, Xuexiang Du, Mingyue Liu, Pan Zheng, Yang Liu   +4 more
doaj   +1 more source

Role of cytotoxic T-lymphocyte antigen 4 (CTLA-4) expression in the pathogenesis of Warthin’s tumor growth

Dental Journal, 2022
Background: One of the benign salivary gland tumors is Warthin’s tumor, which is a benign tumor consisting of a papillary cystic structure covered by a double epithelial layer cells and lymphoid stroma with germinal center.
Alvionika Nadyah Qotrunnada, Tecky Indriana, Jane Kosasih, Meiske Margaretha, Mei Syafriadi   +4 more
doaj   +1 more source