Results 51 to 60 of about 1,332,792 (304)
Immune checkpoint pathways in immunotherapy for head and neck squamous cell carcinoma
, 2020 With the understanding of the complex interaction between the tumour microenvironment and immunotherapy, there is increasing interest in the role of immune regulators in the treatment of head and neck squamous cell carcinoma (HNSCC).
Junwen Huang +7 more
core +1 more source
Immune Checkpoint Molecules in Reproductive Immunology
Frontiers in Immunology, 2019 Immune checkpoint molecules, like CTLA-4, TIM-3, PD-1, are negative regulators of immune responses to avoid immune injury. Checkpoint regulators are thought to actively participate in the immune defense of infections, prevention of autoimmunity ...
Eva Miko +8 more
doaj +1 more source
A context‐dependent modulatory role for eIF6 in acquired resistance to vemurafenib in melanoma
FEBS Letters, EarlyView.Acquired resistance to vemurafenib upregulates the translation factor eIF6 in melanoma cells. Silencing eIF6 in resistant cells reduces proliferation and partially restores drug sensitivity, whereas its overexpression increases sensitivity across melanoma lines regardless of BRAF status, via modulation of mTOR, S6K, and MAPK signaling.
George Kyriakopoulos +9 more
wiley +1 more source
Analysis of Rad3 and Chk1 protein kinases defines different checkpoint responses. [PDF]
, 1998 Eukaryotic cells respond to DNA damage and S phase replication blocks by arresting cell-cycle progression through the DNA structure checkpoint pathways.
Lindsay, Howard D. +6 more
core +4 more sources
CBX4 facilitates EV71 replication by SUMOylation and stabilizing 3D polymerase
Frontiers in MicrobiologyEnterovirus 71 (EV71) is a primary etiological agent of hand-foot-mouth disease (HFMD) in children under 5 years of age and can cause severe neurological disorders even death.
Rui Su +6 more
doaj +1 more source
Key questions about the checkpoint blockade-are microRNAs an answer?
Cancer Biology & Medicine, 2018 The introduction of immune-checkpoint blockade in the cancer therapy led to a paradigm change of the management of late stage cancers. There are already multiple FDA approved checkpoint inhibitors and many other agents are undergoing phase 2 and early ...
Mihnea Dragomir +3 more
doaj +1 more source
Gut microbiota shed new light on the management of immune‐related adverse events
Thoracic Cancer, 2022 Immunotherapy has dramatically revolutionized the therapeutic landscape for patients with cancer. Although immune checkpoint inhibitors are now accepted as effective anticancer therapies, they introduce a novel class of toxicity, termed immune‐related ...
Bei Tan +8 more
doaj +1 more source
The ubiquitin system in normal and infected germinal center B cells
FEBS Letters, EarlyView.The ubiquitin system plays a central role in germinal center (GC) B cells, influencing differentiation to long‐lived memory B cells. Oncogenic gammaherpesviruses gain access to memory B cells by establishing latency in GC B cells. Mapping ubiquitin mechanisms in normal and infected GC B cells will define specific molecular circuits in B cells germane ...
Destiny Davis +2 more
wiley +1 more source
The CD47-SIRPα Immune Checkpoint
Immunity, 2020 The cytotoxic activity of myeloid cells is regulated by a balance of signals that are transmitted through inhibitory and activating receptors. The Cluster of Differentiation 47 (CD47) protein, expressed on both healthy and cancer cells, plays a pivotal role in this balance by delivering a "don't eat me signal" upon binding to the Signal-regulatory ...
Meike E.W. Logtenberg +2 more
openaire +3 more sources
Frontiers in ImmunologyWith global viral emergence and increasing antiviral resistance, there is an urgent need for innovative immunomodulatory strategies. Gut microbiota modulation has gained attention as a promising therapeutic approach. Clostridium butyricum (C.
Shaoju Qian +14 more
doaj +1 more source