Results 31 to 40 of about 29,410 (210)

Augmented Pulmonary Responses to Acute Ozone Exposure in Obese Mice: Roles of TNFR2 and IL-13 [PDF]

, 2014
Background: Acute ozone (O3) exposure results in greater inflammation and airway hyperresponsiveness (AHR) in obese versus lean mice. Objectives: We examined the hypothesis that these augmented responses to O3 are the result of greater signaling through ...
Chen, Lucas, Kasahara, David Itiro, Mathews, Joel Andrew, Shore, Stephanie Ann, Si, Huiqing, Williams, Alison Suzanne, Wurmbrand, Allison Patricia   +6 more
core   +1 more source

Epithelial cell shedding and barrier function: a matter of life and death at the small intestinal villus tip [PDF]

, 2015
The intestinal epithelium is a critical component of the gut barrier. Composed of a single layer of intestinal epithelial cells (IECs) held together by tight junctions, this delicate structure prevents the transfer of harmful microorganisms, antigens ...
A. J. M. Watson, B. J. Campbell, Beaulieu JF, Brown CC, C. A. Duckworth, Casellas F, D. M. Pritchard, Gelberg HB, J. M. Williams, Kaur P, Lee JS, Lobo SM, M. D. Burkitt, Mayhew TM, Moore R, Peschon JJ   +15 more
core   +4 more sources

TNFR2 gene polymorphism in coronary artery disease

Indian Journal of Medical Sciences, 2005
Recently atherosclerosis and coronary artery disease (CAD) are considered to be inflammatory diseases. The genetic polymorphism in inflammatory markers has been well studied and found to be associated with development of CAD.To study the association of biallelic polymorphism at position 196 in exon 6 of tumor necrosis factor 2 (TNFR2) gene and coronary
V H, Sankar, K M, Girisha, A, Gilmour, V P, Singh, N, Sinha, S, Tewari, V, Ramesh, S, Mastana, Suraksha, Agrawal   +8 more
openaire   +2 more sources

Infliximab therapy balances regulatory T cells, tumour necrosis factor receptor 2 (TNFR2) expression and soluble TNFR2 in sarcoidosis [PDF]

Clinical and Experimental Immunology, 2016
Summary Sarcoidosis is a systemic granulomatous disease of unknown aetiology that most commonly affects the lungs. Although elevated levels of regulatory T cells (Tregs) have been reported, the extent to which they play a role in sarcoidosis pathogenesis remains unclear.
Verwoerd, A, Hijdra, D, Vorselaars, A D M, Crommelin, H A, van Moorsel, C H M, Grutters, J C, Claessen, A M E   +6 more
openaire   +3 more sources

Fn14 and TNFR2 as regulators of cytotoxic TNFR1 signaling

Frontiers in Cell and Developmental Biology, 2023
Tumor necrosis factor (TNF) receptor 1 (TNFR1), TNFR2 and fibroblast growth factor-inducible 14 (Fn14) belong to the TNF receptor superfamily (TNFRSF). From a structural point of view, TNFR1 is a prototypic death domain (DD)-containing receptor. In contrast to other prominent death receptors, such as CD95/Fas and the two TRAIL death receptors DR4 and ...
Siegmund, Daniela, Zaitseva, Olena, Wajant, Harald   +2 more
openaire   +4 more sources

Continuous infusion of an agonist of the tumor necrosis factor receptor 2 in the spinal cord improves recovery after traumatic contusive injury. [PDF]

, 2019
AimThe activation of the TNFR2 receptor is beneficial in several pathologies of the central nervous system, and this study examines whether it can ameliorate the recovery process following spinal cord injury.MethodsEHD2-sc-mTNFR2 , an agonist specific ...
Bethea, John R, Blumenthal, Gary H, Bracchi-Ricard, Valerie, Fischer, Roman, Gerald, Marcus J, Kontermann, Roland E, Moxon, Karen A, Nandakumar, Bharadwaj, Pfizenmaier, Klaus, Ricard, Jerome, Williams, Raushaun   +10 more
core   +2 more sources

A TNF receptor 2 selective agonist rescues human neurons from oxidative stress-induced cell death. [PDF]

PLoS ONE, 2011
Tumor necrosis factor (TNF) plays a dual role in neurodegenerative diseases. Whereas TNF receptor (TNFR) 1 is predominantly associated with neurodegeneration, TNFR2 is involved in tissue regeneration and neuroprotection.
Roman Fischer, Olaf Maier, Martin Siegemund, Harald Wajant, Peter Scheurich, Klaus Pfizenmaier   +5 more
doaj   +1 more source

Role of tumor necrosis factor-α and its receptors in diesel exhaust particle-induced pulmonary inflammation [PDF]

, 2017
Inhalation of diesel exhaust particles (DEP) induces an inflammatory reaction in the lung. However, the underlying mechanisms remain to be elucidated. Tumor necrosis factor alpha (TNF-alpha) is a proinflammatory cytokine that operates by binding to tumor
Boon, Louis, Joos, Guy, Kumar, Smitha, Maes, Tania, Provoost, Sharen, Tournoy, Kurt   +5 more
core   +3 more sources

TNF Receptor 2 Makes Tumor Necrosis Factor a Friend of Tumors

Frontiers in Immunology, 2018
Tumor necrosis factor (TNF) is widely accepted as a tumor-suppressive cytokine via its ubiquitous receptor TNF receptor 1 (TNFR1). The other receptor, TNFR2, is not only expressed on some tumor cells but also on suppressive immune cells, including ...
Yuqiao Sheng, Feng Li, Zhihai Qin
doaj   +1 more source

Co-expression of TNF receptors 1 and 2 on melanomas facilitates soluble TNF-induced resistance to MAPK pathway inhibitors

Journal of Translational Medicine, 2022
Background The effectiveness of MAPK pathway inhibitors (MAPKi) used to treat patients with BRAF-mutant melanoma is limited by a range of resistance mechanisms, including soluble TNF (solTNF)-mediated NF-kB signaling.
Cindy A. Sander, Elizabeth A. Rush, Jian Shi, Lidia M. R. B. Arantes, Raymond J. Tesi, Mark A. Ross, Michael J. Calderon, Simon C. Watkins, John M. Kirkwood, Robert L. Ferris, Lisa H. Butterfield, Lazar Vujanovic   +11 more
doaj   +1 more source