Results 11 to 20 of about 29,410 (210)

Therapeutic potential of TNFR2 agonists: a mechanistic perspective

Frontiers in Immunology, 2023
TNFR2 agonists have been investigated as potential therapies for inflammatory diseases due to their ability to activate and expand immunosuppressive CD4+Foxp3+ Treg cells and myeloid-derived suppressor cells (MDSCs).
Yibo Chen, Mengmeng Jiang, Xin Chen, Xin Chen, Xin Chen, Xin Chen   +5 more
doaj   +3 more sources

TNF RECEPTOR 2 AND DISEASE: Autoimmunity and Regenerative Medicine [PDF]

Frontiers in Immunology, 2013
The regulatory cytokine tumor necrosis factor (TNF) exerts its effects through two receptors: TNFR1 and TNFR2. Defects in TNFR2 signaling are evident in a variety of autoimmune diseases.
Denise Louise Faustman, Denise Louise Faustman, Miriam eDavis   +2 more
doaj   +3 more sources

TNFR2: The new Treg switch? [PDF]

OncoImmunology, 2018
Three recent publications identified the TNF/TNR2 pathway as a new target to reduce graft-versus-host-disease through regulatory T cells activation or to potentially switch on a strong anti-leukemic effect through regulatory T cells blockade in ...
José L. Cohen, Kathryn J. Wood
doaj   +4 more sources

Targeting TNFR2 as a Novel Therapeutic Strategy for Alzheimer’s Disease [PDF]

Frontiers in Neuroscience, 2019
Alzheimer’s disease (AD) is a progressive neurodegenerative disorder and the most common cause of dementia. Accumulating experimental evidence shows the important linkage between tumor necrosis factor-α (TNF) and AD, but the exact role of TNF in AD is ...
Natalia Ortí-Casañ, Yingying Wu, Petrus J. W. Naudé, Petrus J. W. Naudé, Peter P. De Deyn, Inge S. Zuhorn, Ulrich L. M. Eisel   +6 more
doaj   +4 more sources

Novel role for the innate immune receptor toll-like receptor 4 (TLR4) in the regulation of the wnt signaling pathway and photoreceptor apoptosis [PDF]

, 2012
Recent evidence has implicated innate immunity in regulating neuronal survival in the brain during stroke and other neurodegenerations. Photoreceptors are specialized light-detecting neurons in the retina that are essential for vision.
A Poltorak, A Wenzel, Abigail S. Hackam, AK Silva, AL Kindzelskii, Amit K. Patel, AO Edwards, AS Hackam, B Marsh, BJ Marsh, BJ Marsh, C Bowes, C Liu, C Niehrs, C Zhang, Chhinder P. Sodhi, CP Sodhi, CY Logan, D Jiang, David J. Hackam, DJ Kaczorowski, E Cario, E Chaum, E Okun, F Hua, F Limana, G Faraco, G Tezel, GA Limb, GM Seigel, GR Barile, GS Hageman, GT Higgins, H Yi, H Yi, HL Rosenzweig, HL Rosenzweig, HP Scholl, Hyun Yi, IA El-Ghrably, J Merenmies, J Qiu, J Watson, JK Shen, JR Caso, K Hoshino, K Kaarniranta, K Miyake, K Takeda, KP Mollen, L Barandon, L Minghetti, M Mizukami, MA Fragoso, Mauricio Martins Rodrigues, MD Gordon, MK Ko, MT Lotze, N Arimura, P Matzinger, PJ Franco, PY Leung, Q Xing, R Gauthier, R Gorina, R Kacimi, R Seitz, R Shechter, RM Vabulas, RR Caspi, RT Moon, S Lehnardt, S Lin, S Tell, S Walter, S Zareparsi, SC Gribar, SC Tang, SC Tang, SR Coats, T Ha, T Harada, T Harada, T Nakazawa, U Kilic, V Bocchini, V Fontaine, Y de Kozak, Y Xin, Z Tu   +89 more
core   +20 more sources

Chemotherapy Shifts the Balance in Favor of CD8+ TNFR2+ TILs in Triple-Negative Breast Tumors

Cells, 2021
Triple-negative breast cancer (TNBC) is primarily treated via chemotherapy; in parallel, efforts are made to introduce immunotherapies into TNBC treatment. CD4+ TNFR2+ lymphocytes were reported as Tregs that contribute to tumor progression.
Tamir Baram, Nofar Erlichman, Maya Dadiani, Nora Balint-Lahat, Anya Pavlovski, Tsipi Meshel, Dana Morzaev-Sulzbach, Einav Nili Gal-Yam, Iris Barshack, Adit Ben-Baruch   +9 more
doaj   +1 more source

Targeting TNFR2: A Novel Breakthrough in the Treatment of Cancer

Frontiers in Oncology, 2022
Tumor necrosis factor (TNF) receptor type II (TNFR2) is expressed in various tumor cells and some immune cells, such as regulatory T cells and myeloid-derived suppressing cells. TNFR2 contributes a lot to the tumor microenvironment.
Muchun Li, Muchun Li, Muchun Li, Muchun Li, Xiaozhen Zhang, Xiaozhen Zhang, Xiaozhen Zhang, Xiaozhen Zhang, Xueli Bai, Xueli Bai, Xueli Bai, Xueli Bai, Tingbo Liang, Tingbo Liang, Tingbo Liang, Tingbo Liang, Tingbo Liang   +16 more
doaj   +1 more source

Novel anti-tumour necrosis factor receptor-1 (TNFR1) domain antibody prevents pulmonary inflammation in experimental acute lung injury. [PDF]

, 2018
BACKGROUND: Tumour necrosis factor alpha (TNF-α) is a pleiotropic cytokine with both injurious and protective functions, which are thought to diverge at the level of its two cell surface receptors, TNFR1 and TNFR2.
Bareille, Philippe Jean, Bayliffe, Andrew, Brown, Vanessa, Chen, Younan, Chilvers, Edwin R, Cordy, Joanna, de Wildt, Ruud, Elborn, Stuart, Griffiths, Mark, Hamid, Umar I, Hind, Matthew, McAuley, Daniel Francis, Morley, Peter, O'Kane, Cecilia M, Proudfoot, Alastair, Serone, Adrian, Summers, Charlotte, Wilson, Robert, Wright, Tracey   +18 more
core   +4 more sources

Cyclophosphamide abrogates the expansion of CD4+Foxp3+ regulatory T cells and enhances the efficacy of bleomycin in the treatment of mouse B16-F10 melanomas

Cancer Biology & Medicine, 2021
Objective: Promotion of the proliferative expansion of CD4+Foxp3+ regulatory T cells (Tregs) is one of the side effects that limits the use of bleomycin (BLM) in the treatment of tumors. In this study, we examined the hypothesis that cyclophosphamide (CY)
Ping Li, Fengyang Chen, Jingbin Zheng, Yang Yang, Yuan Li, Yifei Wang, Xin Chen   +6 more
doaj   +1 more source

Obesity and airway responsiveness: Role of TNFR2 [PDF]

Pulmonary Pharmacology & Therapeutics, 2013
Obese mice exhibit innate airway hyperresponsiveness (AHR), a feature of asthma. Tumor necrosis factor alpha (TNFα) is implicated in the disease progression and chronic inflammatory status of both obesity and asthma. TNF acts via two TNF receptors, TNFR1 and TNFR2.
Alison S, Williams, Lucas, Chen, David I, Kasahara, Huiqing, Si, Allison P, Wurmbrand, Stephanie A, Shore   +5 more
openaire   +2 more sources