Results 21 to 30 of about 29,410 (210)
Life, 2021 Despite the fact that accumulation of microglia, the resident macrophages of the central nervous system (CNS) are the main feature of glioblastoma, the role of microglia in the progression of glioma is still arguable.
Chih-Kai Liao +5 more
doaj +1 more source
Targeted killing of TNFR2-expressing tumor cells and Tregs by TNFR2 antagonistic antibodies in advanced Sézary syndrome [PDF]
Leukemia, 2018 Sézary syndrome (SS) is a rare form of cutaneous T-cell lymphoma often refractory to treatment. SS is defined as adenopathy, erythroderma with high numbers of atypical T cells. This offers an opportunity for new interventions and perhaps antibody-based therapeutic by virtue of its high expression of the TNFR2 oncogene on the tumor cells and on T ...
Torrey, H +6 more
openaire +2 more sources
Inflammation induces pro-NETotic neutrophils via TNFR2 signaling
Cell Reports, 2022 Cytokines released during chronic inflammatory diseases induce pro-inflammatory properties in polymorphonuclear neutrophils (PMNs). Here, we describe the development of a subgroup of human PMNs expressing CCR5, termed CCR5+ PMNs. Auto- and paracrine tumor necrosis factor (TNF) signaling increases intracellular neutrophil elastase (ELANE) abundance and ...
Friederike Neuenfeldt +14 more
openaire +2 more sources
Key inflammatory pathway activations in the MCI stage of Alzheimer's disease [PDF]
, 2019 OBJECTIVE: To determine the key inflammatory pathways that are activated in the peripheral and CNS compartments at the mild cognitive impairment (MCI) stage of Alzheimer's disease (AD).
Bekris, Lynn M. +7 more
core +2 more sources
Cells, 2021 Tumor necrosis factor receptor 1 and 2 (TNFR1 and TNFR2) have been found in brain parenchyma of stroke patients, and plasma levels are increased in the acute phase of stroke.
Rikke B. Hansen +8 more
doaj +1 more source
Mechanisms of Sex Differences in TNFR2-Mediated Cardioprotection [PDF]
Circulation, 2008 Background— TNFR1/TNFR2 signaling may mediate different cellular and molecular responses (injury versus protection) and the balance may be affected by sex hormones. Previous studies have shown that females have improved myocardial functional recovery, TNFR1 signaling resistance, and increased SOCS3 ...
Meijing, Wang +4 more
openaire +2 more sources
TNFR1 and TNFR2 Signaling Interplay in Cardiac Myocytes [PDF]
Journal of Biological Chemistry, 2007 Tumor necrosis factor alpha (TNFalpha) plays a major role in chronic heart failure, signaling through two different receptor subtypes, TNFR1 and TNFR2. Our aim was to further delineate the functional role and signaling pathways related to TNFR1 and TNFR2 in cardiac myocytes.
Nicole, Defer +3 more
openaire +2 more sources
Atsttrin Promotes Cartilage Repair Primarily Through TNFR2-Akt Pathway [PDF]
Frontiers in Cell and Developmental Biology, 2020 Cartilage defects account for substantial economic and humanistic burdens and pose a significant clinical problem. The efficacy of clinical approaches to cartilage repair is often inadequate, in part, owing to the restricted proliferative capacity of chondrocytes.
Jianlu Wei +5 more
openaire +3 more sources
Ectodomain shedding of the amyloid precursor protein: Cellular control mechanisms and novel modifiers [PDF]
, 2006 Proteolytic cleavage in the ectodomain of the amyloid precursor protein (APP) is a key regulatory step in the generation of the Alzheimer's disease amyloid-beta (A beta) pepticle and occurs through two different protease activities termed alpha- and beta-
Lichtenthaler, Stefan F.
core +1 more source
Journal of Orthopaedic Translation, 2021 Background: Elevated tumor necrosis factor alpha (TNF-α) expression is correlated with the progression of intervertebral disc degeneration (IVDD). Progranulin binding to tumor necrosis factor receptor (TNFR) and its derivative Atsttrin are effective for ...
Shanzheng Wang +5 more
doaj +1 more source