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Mas-Related G-Protein-Coupled Receptors: Emerging Roles in Neuropathic Pain [PDF]

Biomolecules
Mas-related G-protein-coupled receptors constitute a distinct family of GPCRs expressed in some subsets of sensory neurons and immune cells. Increasing evidence highlights their contribution to the modulation of nociceptive signaling and neuroimmune ...
Mario García-Domínguez
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G protein-coupled receptors and obesity

Frontiers in Endocrinology, 2023
G protein-coupled receptors (GPCRs) have emerged as important drug targets for various chronic diseases, including obesity and diabetes. Obesity is a complex chronic disease that requires long term management predisposing to type 2 diabetes, heart ...
Alessandro Pocai
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G Protein-Coupled Receptors in Osteoarthritis

Frontiers in Endocrinology, 2022
Osteoarthritis (OA) is the most common chronic joint disease characterized, for which there are no available therapies being able to modify the progression of OA and prevent long-term disability. Critical roles of G-protein coupled receptors (GPCRs) have
Fanhua Wang, Mingyao Liu, Ning Wang, Jian Luo, Jian Luo   +4 more
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Hemorphins Targeting G Protein-Coupled Receptors

Pharmaceuticals, 2021
Hemorphins are short peptides produced by the proteolysis of the beta subunit of hemoglobin. These peptides have diverse physiological effects especially in the nervous and the renin-angiotensin systems.
Mohammed Akli Ayoub, Ranjit Vijayan
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Advances on Mrgprs itch receptors and their ligands

Pifu-xingbing zhenliaoxue zazhi, 2023
Although histamine is an important physiologically active substance in pruritus,antihistamine drugs can only relieve a small proportion of symptoms in chronic pruritus.
Jing HU, Zhijian CAO
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Functional optimization of light-activatable Opto-GPCRs: Illuminating the importance of the proximal C-terminus in G-protein specificity

Frontiers in Cell and Developmental Biology, 2023
Introduction: G-protein coupled receptors (GPCRs) are the largest family of human receptors that transmit signals from natural ligands and pharmaceutical drugs into essentially every physiological process.
Siri Leemann, Sonja Kleinlogel
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Atropine-functionalized gold nanoparticles binding to muscarinic receptors after passage across the intestinal epithelium

Royal Society Open Science, 2022
Gold nanoparticles have a high potential to be a treatment of diseases by their specific drug delivery properties and multivalent receptor stimulation.
Rebecca Claßen, Ervice Pouokam, Matthias Wickleder, Martin Diener, Annabelle Mattern   +4 more
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Constitutive Activity among Orphan Class-A G Protein Coupled Receptors. [PDF]

PLoS ONE, 2015
The purpose of this study was to evaluate the extent of constitutive activity among orphan class-A G protein coupled receptors within the cAMP signaling pathway.
Adam L Martin, Michael A Steurer, Robert S Aronstam   +2 more
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Rules and mechanisms governing G protein coupling selectivity of GPCRs

Cell Reports, 2023
Summary: G protein-coupled receptors (GPCRs) convert extracellular stimuli into intracellular signaling by coupling to heterotrimeric G proteins of four classes: Gi/o, Gq, Gs, and G12/13.
Ikuo Masuho, Ryoji Kise, Pablo Gainza, Ee Von Moo, Xiaona Li, Ryosuke Tany, Hideko Wakasugi-Masuho, Bruno E. Correia, Kirill A. Martemyanov   +8 more
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G Protein-Coupled Receptors: Undervalued Targets for Cancer Therapy

Iraqi Journal of Pharmaceutical Sciences, 2022
Despite the G protein-coupled receptors (GPCRs) being the largest family of signalling proteins at the surface of cells, their potential to be targeted in cancer therapy is still under-utilised.
Ismail Ibrahim Al-Janabi
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