Results 31 to 40 of about 15,824,548 (164)

G Protein-Coupled Receptor Kinases Take Central Stage

Cells, 2022
The relevance of the family of G protein-coupled receptor kinases (GRKs) is based on its key participation in the regulation and intracellular dynamics of the largest family of membrane receptors, namely G protein-coupled receptors (GPCRs) [...]
Federico Mayor, Cristina Murga
doaj   +1 more source

Designer lipid-like peptides [PDF]

, 2011
A crucial bottleneck in membrane protein studies, particularly G-protein coupled receptors, is the notorious difficulty of finding an optimal detergent that can solubilize them and maintain their stability and function. Here we report rapid production of
Braun, Dieter, Song, Junyao, Wang, Xiaoqiang, Jerabek-Willemsen, Moran, Luo, Yuan, Baaske, Philipp, Wienken, Christoph J., Zhang, Shuguang, Corin, Karolina, Duhr, Stefan, Ravel, Deepali B., Brown, Emily   +11 more
core   +1 more source

Functional expression of opioid receptors and other human GPCRs in yeast engineered to produce human sterols

Nature Communications, 2022
The yeast Saccharomyces cerevisiae is powerful for studying human G protein-coupled receptors as they can be coupled to its mating pathway. Here the authors engineer baker’s yeast to produce human sterols and show that vertebrate G protein coupled ...
Björn D. M. Bean, Colleen J. Mulvihill, Riddhiman K. Garge, Daniel R. Boutz, Olivier Rousseau, Brendan M. Floyd, William Cheney, Elizabeth C. Gardner, Andrew D. Ellington, Edward M. Marcotte, Jimmy D. Gollihar, Malcolm Whiteway, Vincent J. J. Martin   +12 more
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Interaction of Prokineticin Receptors with Accessory Proteins

Encyclopedia, 2023
G protein-coupled receptors (GPCRs) are transmembrane proteins that mediate the intracellular pathway of signals not only through heterotrimeric GTP-binding proteins (G proteins) but also through their associations with a variety of additional partner ...
Roberta Lattanzi, Rossella Miele
doaj   +1 more source

GPCRs in Intracellular Compartments: New Targets for Drug Discovery

Biomolecules, 2022
The architecture of eukaryotic cells is defined by extensive membrane-delimited compartments, which entails separate metabolic processes that would otherwise interfere with each other, leading to functional differences between cells.
Irene Fasciani, Marco Carli, Francesco Petragnano, Francesco Colaianni, Gabriella Aloisi, Roberto Maggio, Marco Scarselli, Mario Rossi   +7 more
doaj   +1 more source

Lysophosphatidic Acid Signaling in Cancer Cells: What Makes LPA So Special?

Cells, 2021
Lysophosphatidic acid (LPA) refers to a family of simple phospholipids that act as ligands for G protein-coupled receptors. While LPA exerts effects throughout the body in normal physiological circumstances, its pathological role in cancer is of great ...
Pravita Balijepalli, Ciera C. Sitton, Kathryn E. Meier   +2 more
doaj   +1 more source

G Protein–Coupled Receptor Heteromers [PDF]

Annual Review of Pharmacology and Toxicology, 2016
G protein-coupled receptors (GPCRs) compose one of the largest families of membrane proteins involved in intracellular signaling. They are involved in numerous physiological and pathological processes and are prime candidates for drug development. Over the past decade, an increasing number of studies have reported heteromerization between GPCRs.
Gomes, Ivone, Ayoub, Mohammed Akli, Fujita, Wakako, Jaeger, Werner C., Pfleger, Kevin D.G., Devi, Lakshmi A.   +5 more
openaire   +3 more sources

Similarity between class A and class B G-protein-coupled receptors exemplified through calcitonin gene-related peptide receptor modelling and mutagenesis studies [PDF]

, 2012
Modelling class B G-protein-coupled receptors (GPCRs) using class A GPCR structural templates is difficult due to lack of homology. The plant GPCR, GCR1, has homology to both class A and class B GPCRs. We have used this to generate a
Poyner, David, Reynolds, Christopher A., Hay, Debbie L., Poyner, David R, Barwell, James, Upton, Graham J.G., Poyner, David R., Reeves, Philip J., Upton, Graham J. G., Taddese, Bruck, Reeves, Philip J, Reynolds, Christopher A, Conner, Alex C., Hay, Debbie L, Conner, Alex C, Vohra, Shabana, Upton, Graham JG   +16 more
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The Protein Arginine Methyltransferase PRMT-5 Regulates SER-2 Tyramine Receptor-Mediated Behaviors in Caenorhabditis elegans

G3: Genes, Genomes, Genetics, 2018
G protein-coupled receptors are 7-pass transmembrane receptors that couple to heterotrimeric G proteins to mediate cellular responses to a diverse array of stimuli.
Alexander Bowitch, Kerry L. Michaels, Michael C. Yu, Denise M. Ferkey   +3 more
doaj   +1 more source

Fever-like temperature modification differentially affects in vitro signaling of bradykinin B-1 and B-2 receptors [PDF]

, 2011
The bradykinin (BK) B-2 and B-1 receptors (B2R, B1R) belong to the rhodopsin-like G protein-coupled receptors (GPCRs) and are involved in (patho)physiological processes such as blood pressure regulation or inflammation.
Dinkel, Klaus, Faussner, Alexander, Marianne Jochum, Jasmin Leschner, Alexander Faussner, Jochum, Marianne, Leschner, Jasmin, Larisa Ring, Ring, Larisa, Jens Feierler, Feierler, Jens, Klaus Dinkel   +11 more
core   +1 more source