Interaction of Prokineticin Receptors with Accessory Proteins
Encyclopedia, 2023 G protein-coupled receptors (GPCRs) are transmembrane proteins that mediate the intracellular pathway of signals not only through heterotrimeric GTP-binding proteins (G proteins) but also through their associations with a variety of additional partner ...
Roberta Lattanzi, Rossella Miele
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G Protein-Coupled Receptors in Taste Physiology and Pharmacology
Frontiers in Pharmacology, 2020 Heterotrimeric G protein-coupled receptors (GPCRs) comprise the largest receptor family in mammals and are responsible for the regulation of most physiological functions.
Raise Ahmad, Julie E. Dalziel
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Regulators of G protein signalling proteins in the human myometrium [PDF]
, 2009 The contractile state of the human myometrium is controlled by extracellular signals that promote relaxation or contraction. Many of these signals function through G proteincoupled receptors at the cell surface, stimulating heterotrimeric G proteins and ...
Abramow-Newerly +52 more
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GPCRs in Intracellular Compartments: New Targets for Drug Discovery
Biomolecules, 2022 The architecture of eukaryotic cells is defined by extensive membrane-delimited compartments, which entails separate metabolic processes that would otherwise interfere with each other, leading to functional differences between cells.
Irene Fasciani +7 more
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Molecular mechanisms mediating the G protein-coupled receptor regulation of cell cycle progression [PDF]
, 2007 G protein-coupled receptors are key regulators of cellular communication, mediating the efficient coordination of a cell's responses to extracellular stimuli.
New, David C., Wong, Yung Hou
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G-protein-coupled receptor kinases
Trends in Biochemical Sciences, 1991 Rhodopsin kinase and the beta-adrenergic receptor kinase (beta ARK) catalyse the phosphorylation of the activated forms of the G-protein-coupled receptors, rhodopsin and the beta 2-adrenergic receptor (beta 2AR), respectively. The interaction between receptor and kinase is independent of second messengers and appears to involve a multipoint attachment ...
Palczewskl, Krzvsztof +1 more
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Lysophosphatidic Acid Signaling in Cancer Cells: What Makes LPA So Special?
Cells, 2021 Lysophosphatidic acid (LPA) refers to a family of simple phospholipids that act as ligands for G protein-coupled receptors. While LPA exerts effects throughout the body in normal physiological circumstances, its pathological role in cancer is of great ...
Pravita Balijepalli +2 more
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Positive allosteric modulators of the a-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptor [PDF]
, 2010 L-glutamate is the major excitatory neurotransmitter in the mammalian central nervous system (CNS) and plays a fundamental role in the control of motor function, cognition and mood.
Grove, Simon J .A. +4 more
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G3: Genes, Genomes, Genetics, 2018 G protein-coupled receptors are 7-pass transmembrane receptors that couple to heterotrimeric G proteins to mediate cellular responses to a diverse array of stimuli.
Alexander Bowitch +3 more
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Cloning, characterization and expression of a G-protein-coupled receptor from Lymnaea stagnalis and identification of a leucokinin-like peptide, PSFHSWS amide as its endogenous ligand. [PDF]
, 1997 Neuropeptides are known to be important signaling molecules in several neural systems of the pond snailLymnaea stagnalis. Although the functions of these peptides have been studied in many neurons, the nature of the postsynaptic signal transduction is ...
Burke, J.F. +7 more
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