Results 41 to 50 of about 15,824,548 (164)

Plasma membrane preassociation drives β-arrestin coupling to receptors and activation [PDF]

, 2023
β-arrestin plays a key role in G protein-coupled receptor (GPCR) signaling and desensitization. Despite recent structural advances, the mechanisms that govern receptor-β-arrestin interactions at the plasma membrane of living cells remain elusive.
O’Brien, Shannon L., Stepniewski, Tomasz M, Hill, Stephen J., Maria Makarova, Hoffmann, Carsten, Mistry, Ravi, Shannon L. O’Brien, Davide Calebiro, Stephen J. Hill, Carsten Hoffmann, Julia Drube, Jana Selent, Baidya, Mithu, Calebiro, Davide, Mithu Baidya, Lanoiselée, Yann, Medel-Lacruz, Brian, Owen, Dylan M., Owen, Dylan M, Stepniewski, Tomasz M., Tamara Miljus, Dylan M. Owen, Miljus, Tamara, Goulding, Joëlle, Stepniewski, Tomasz Maciej, 1988-, Grimes, Jak, Hill, Stephen J, Drube, Julia, Jak Grimes, Ravi Mistry, Medel Lacruz, Brian, Koszegi, Zsombor; id_orcid, Zsombor Koszegi, Arun K. Shukla, Koszegi, Zsombor, Makarova, Maria, Yann Lanoiselée, Selent, Jana, Brian Medel-Lacruz, O'Brien, Shannon L., Tomasz M. Stepniewski, O'Brien, Shannon L; id_orcid, Shukla, Arun K., Shukla, Arun K, Joëlle Goulding   +44 more
core   +1 more source

Frizzled Proteins are bona fide G Protein-Coupled Receptors [PDF]

, 2009
Receptors of the Frizzled family initiate Wnt ligand-dependent signaling controlling multiple steps in organism development and highly conserved in evolution. Misactivation of the Wnt/Frizzled signaling is cancerogenic.
Silke Buestorf, Vladimir L. Katanaev
core  

An artificial immune system for clustering amino acids in the context of protein function classification [PDF]

, 2009
This paper addresses the classification task of data mining (a form of supervised learning) in the context of an important bioinformatics problem, namely the prediction of protein functions.
Timmis, Jon, Clark, Edward, Flower, Darren R., Secker, Andrew D., Davies, Matthew N., Freitas, Alex A.   +5 more
core   +1 more source

G‐protein‐coupled receptors and melanoma [PDF]

Pigment Cell & Melanoma Research, 2008
SummaryG‐protein‐coupled receptors (GPCR) are the largest family of receptors with over 500 members. Evaluation of GPCR gene expression in primary human tumors identified over‐expression of GPCR in several tumor types. Analysis of cancer samples in different disease stages also suggests that some GPCR may be involved in early tumor progression and ...
Hwa Jin, Lee, Brian, Wall, Suzie, Chen
openaire   +2 more sources

Inferring the lifetime of endosomal protein complexes by fluorescence recovery after photobleaching [PDF]

, 2008
Cellular signal transduction is dynamic, with signaling proteins continually associating and dissociating into and from protein complexes. Here we present a fluorescence recovery after photobleaching technique to determine the lifetime of protein ...
Gousseva, Veronika, Laporte, Stéphane A., Swain, Peter S, Swain, Peter S., Simaan, May, Laporte, Stéphane A   +5 more
core   +1 more source

G-Protein Coupled Receptors Targeted by Analgesic Venom Peptides

Toxins, 2017
Chronic pain is a complex and debilitating condition associated with a large personal and socioeconomic burden. Current pharmacological approaches to treating chronic pain such as opioids, antidepressants and anticonvulsants exhibit limited efficacy in ...
James T. Daniel, Richard J. Clark
doaj   +1 more source

Fusion protein strategies for cryo-EM study of G protein-coupled receptors

Nature Communications, 2022
Here, Zhang et al. explore fusion protein strategies to facilitate cryo-EM structural studies of GPCRs alone- without signal transducers- in ligand bound or unliganded form.
Kaihua Zhang, Hao Wu, Nicholas Hoppe, Aashish Manglik, Yifan Cheng   +4 more
doaj   +1 more source

G-protein coupled receptor structure

Biochimica et Biophysica Acta (BBA) - Biomembranes, 2007
Because of their central role in regulation of cellular function, structure/function relationships for G-protein coupled receptors (GPCR) are of vital importance, yet only recently have sufficient data been obtained to begin mapping those relationships. GPCRs regulate a wide range of cellular processes, including the senses of taste, smell, and vision,
Yeagle, Philip L., Albert, Arlene D.
openaire   +2 more sources

GPCRTree: online hierarchical classification of GPCR function [PDF]

, 2008
Background: G protein-coupled receptors (GPCRs) play important physiological roles transducing extracellular signals into intracellular responses. Approximately 50% of all marketed drugs target a GPCR.
Davies Matthew N, Clark, Edward, Halling-Brown Mark, Flower Darren R, Moss, David S., Alex A Freitas, Halling-Brown, Mark D., Clark, E., Timmis Jon, Flower, Darren R, Andrew Secker, Freitas, Alex A., Timmis, J., Davies, M.N., David S Moss, Secker, Andrew D., Secker, A., Halling-Brown, Mark, Moss David S, Timmis, Jon, Freitas, A.A., Mark Halling-Brown, Clark Edward, Secker Andrew, Secker, Andrew, Flower, Darren R., Jon Timmis, Edward Clark, Matthew N Davies, Freitas Alex A, Davies, Matthew N., Darren R Flower, Flower, D.R.   +32 more
core   +1 more source

G Protein-Coupled Receptors in Cancer [PDF]

International Journal of Molecular Sciences, 2016
Despite the fact that G protein-coupled receptors (GPCRs) are the largest signal-conveying receptor family and mediate many physiological processes, their role in tumor biology is underappreciated. Numerous lines of evidence now associate GPCRs and their downstream signaling targets in cancer growth and development.
Bar-Shavit, Rachel, Maoz, Myriam, Kancharla, Arun, Nag, Jeetendra Kumar, Agranovich, Daniel, Grisaru-Granovsky, Sorina, Uziely, Beatrice   +6 more
openaire   +2 more sources