Results 21 to 30 of about 15,824,548 (164)

Neuropeptide G Protein-Coupled Receptors as Oncotargets

Frontiers in Endocrinology, 2018
Neuropeptide G protein-coupled receptors (GPCRs) are overexpressed on numerous cancer cells. In a number of tumors, such as small cell lung cancer (SCLC), bombesin (BB) like peptides and neurotensin (NTS) function as autocrine growth factors whereby they
Terry W. Moody, Irene Ramos-Alvarez, Robert T. Jensen   +2 more
doaj   +1 more source

Role of G-protein coupled receptors in cardiovascular diseases

Frontiers in Cardiovascular Medicine, 2023
Cardiovascular diseases (CVDs) are the leading cause of death globally, with CVDs accounting for nearly 30% of deaths worldwide each year. G-protein-coupled receptors (GPCRs) are the most prominent family of receptors on the cell surface, and play an ...
Yuanqiang Li, Boyu Li, Wei-Dong Chen, Wei-Dong Chen, Yan-Dong Wang   +4 more
doaj   +1 more source

Regulating G protein-coupled receptors by topological inversion

eLife, 2019
G protein-coupled receptors (GPCRs) are a family of proteins containing seven transmembrane helices, with the N- and C-terminus of the protein located at the extracellular space and cytosol, respectively.
Bray Denard, Sungwon Han, JungYeon Kim, Elliott M Ross, Jin Ye   +4 more
doaj   +1 more source

GPCR-OKB: the G protein coupled receptor oligomer knowledge base [PDF]

, 2010
Rapid expansion of available data about G Protein Coupled Receptor (GPCR) dimers/oligomers over the past few years requires an effective system to organize this information electronically.
Bas Vroling, Pin, J.-P., Palczewski, K., Camacho-Artacho, Marta, Pin, J.P., Lucy Skrabanek, Jean-Philippe Pin, Marta Camacho-Artacho, Devi, Lakshmi A, Graeme Milligan, Marta Filizola, Campagne, Fabien, Fabien Campagne, Martin J. Lohse, Jufang Shan, Lohse, Martin J, Vriend, Gerrit, Khelashvili, George, Milligan, Graeme, Camacho-Artacho, M., Skrabanek, L., George Khelashvili, Campagne, F., Susan R. George, Lakshmi A. Devi, Filizola, M., Pin, Jean-Philippe, Vroling, B., Bouvier, M., Devi, L.A., Richard R. Neubig, Marc Parmentier, George, Susan R, Palczewski, Krzysztof, Dorff, K., Shan, J., Vriend, G., Michel Bouvier, Lohse, M.J., Bouvier, Michel, Skrabanek, Lucy, Vroling, Bas, Filizola, Marta, Neubig, Richard R, Gerrit Vriend, Dorff, Kevin, Parmentier, Marc, Khelashvili, G., Javitch, J.A., Shan, Jufang, Parmentier, M., Javitch, Jonathan A, Krzysztof Palczewski, Kevin Dorff, Jonathan A. Javitch, George, S.R., Neubig, R.R., Milligan, G.   +57 more
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Peptide ligand recognition by G protein-coupled receptors

Frontiers in Pharmacology, 2015
The past few years have seen spectacular progress in the structure determination of G protein-coupled receptors (GPCRs). We now have structural representatives from classes A, B, C, and F.
Brian E Krumm, Reinhard eGrisshammer
doaj   +1 more source

Regulators of G protein signalling proteins in the human myometrium [PDF]

, 2009
The contractile state of the human myometrium is controlled by extracellular signals that promote relaxation or contraction. Many of these signals function through G proteincoupled receptors at the cell surface, stimulating heterotrimeric G proteins and ...
Ladds, Graham, Thornton, Steven, Zervou, Sevasti I., Vatish, Manu, Davey, John   +4 more
core   +1 more source

G-Protein coupled receptors: answers from simulations

Beilstein Journal of Organic Chemistry, 2017
Molecular-dynamics (MD) simulations are playing an increasingly important role in research into the modes of action of G-protein coupled receptors (GPCRs).
Timothy Clark
doaj   +1 more source

Presynaptic G Protein-Coupled Receptors: Gatekeepers of Addiction?

Frontiers in Cellular Neuroscience, 2016
Drug abuse and addiction cause widespread social and public health problems, and the neurobiology underlying drug actions and drug use and abuse is an area of intensive research.
Kari A Johnson, David M Lovinger
doaj   +1 more source

G Protein-Coupled Receptors in Taste Physiology and Pharmacology

Frontiers in Pharmacology, 2020
Heterotrimeric G protein-coupled receptors (GPCRs) comprise the largest receptor family in mammals and are responsible for the regulation of most physiological functions.
Raise Ahmad, Julie E. Dalziel
doaj   +1 more source

Signal Transduction of Sphingosine-1-Phosphate G Protein—Coupled Receptors

The Scientific World Journal, 2006
Sphingosine-1-phosphate (S1P) is a bioactive lipid capable of eliciting dramatic effects in a variety of cell types. Signaling by this molecule is by a family of five G protein—coupled receptors named S1P1–5 that signal through a variety of pathways to ...
Nicholas Young, James R. Van Brocklyn
doaj   +1 more source