Results 21 to 30 of about 81,481 (258)

GPCR-FEX: A Fluoride-Based Selection System for Rapid GPCR Screening and Engineering

, 2022
The directed evolution of proteins comprises a search of sequence space for variants that improve a target phenotype, yet identification of desirable variants is inherently limited by library size and screening ability.
Tejas A. Navaratna (11896707), Michelle A. O’Malley, Justin I. Yoo, Justin I. Yoo (5482058), Tejas A. Navaratna, Michelle A. O’Malley (1444552), Patrick Kolence (11896710), Patrick Kolence   +7 more
core   +1 more source

GPCR-OKB: the G protein coupled receptor oligomer knowledge base [PDF]

, 2010
Rapid expansion of available data about G Protein Coupled Receptor (GPCR) dimers/oligomers over the past few years requires an effective system to organize this information electronically.
Bas Vroling, Pin, J.-P., Palczewski, K., Camacho-Artacho, Marta, Pin, J.P., Lucy Skrabanek, Jean-Philippe Pin, Marta Camacho-Artacho, Devi, Lakshmi A, Graeme Milligan, Marta Filizola, Campagne, Fabien, Fabien Campagne, Martin J. Lohse, Jufang Shan, Lohse, Martin J, Vriend, Gerrit, Khelashvili, George, Milligan, Graeme, Camacho-Artacho, M., Skrabanek, L., George Khelashvili, Campagne, F., Susan R. George, Lakshmi A. Devi, Filizola, M., Pin, Jean-Philippe, Vroling, B., Bouvier, M., Devi, L.A., Richard R. Neubig, Marc Parmentier, George, Susan R, Palczewski, Krzysztof, Dorff, K., Shan, J., Vriend, G., Michel Bouvier, Lohse, M.J., Bouvier, Michel, Skrabanek, Lucy, Vroling, Bas, Filizola, Marta, Neubig, Richard R, Gerrit Vriend, Dorff, Kevin, Parmentier, Marc, Khelashvili, G., Javitch, J.A., Shan, Jufang, Parmentier, M., Javitch, Jonathan A, Krzysztof Palczewski, Kevin Dorff, Jonathan A. Javitch, George, S.R., Neubig, R.R., Milligan, G.   +57 more
core   +3 more sources

Nuclear localization of histamine receptor 2 in primary human lymphatic endothelial cells

Biology Open, 2022
Histamine exerts its physiological functions through its four receptor subtypes. In this work, we report the subcellular localization of histamine receptor 2 (H2R), a G protein-coupled receptor (GPCR), which is expressed in a wide variety of cell and ...
Sarit Pal, Anatoliy Gashev, Debarshi Roy
doaj   +1 more source

GPCRTree: online hierarchical classification of GPCR function [PDF]

, 2008
Background: G protein-coupled receptors (GPCRs) play important physiological roles transducing extracellular signals into intracellular responses. Approximately 50% of all marketed drugs target a GPCR.
Davies Matthew N, Clark, Edward, Halling-Brown Mark, Flower Darren R, Moss, David S., Alex A Freitas, Halling-Brown, Mark D., Clark, E., Timmis Jon, Flower, Darren R, Andrew Secker, Freitas, Alex A., Timmis, J., Davies, M.N., David S Moss, Secker, Andrew D., Secker, A., Halling-Brown, Mark, Moss David S, Timmis, Jon, Freitas, A.A., Mark Halling-Brown, Clark Edward, Secker Andrew, Secker, Andrew, Flower, Darren R., Jon Timmis, Edward Clark, Matthew N Davies, Freitas Alex A, Davies, Matthew N., Darren R Flower, Flower, D.R.   +32 more
core   +1 more source

A computational model for GPCR-ligand interaction prediction

Journal of Integrative Bioinformatics, 2020
G protein-coupled receptors (GPCRs) play an essential role in critical human activities, and they are considered targets for a wide range of drugs. Accordingly, based on these crucial roles, GPCRs are mainly considered and focused on pharmaceutical ...
Karimi Shiva, Ahmadi Maryam, Goudarzi Farjam, Ferdousi Reza   +3 more
doaj   +1 more source

Nutrient sensing and cAMP signaling in yeast: G-protein coupled receptor versus transceptor activation of PKA

Microbial Cell, 2020
A major signal transduction pathway regulating cell growth and many associated physiological properties as a function of nutrient availability in the yeast Saccharomyces cerevisiae is the protein kinase A (PKA) pathway.
Griet Van Zeebroeck, Liesbeth Demuyser, Zhiqiang Zhang, Ines Cottignie, Johan M. Thevelein   +4 more
doaj   +1 more source

On the hierarchical classification of G Protein-Coupled Receptors [PDF]

, 2007
Motivation: G protein-coupled receptors (GPCRs) play an important role in many physiological systems by transducing an extracellular signal into an intracellular response. Over 50% of all marketed drugs are targeted towards a GPCR.
Matthew N. Davies, Timmis, Jon, Miguel Mendao, Flower, Darren R., Secker, Andrew D., Jon Timmis, Mendao, Miguel, Alex A. Freitas, Davies, Matthew N., Andrew Secker, Freitas, Alex A., Darren R. Flower   +11 more
core   +1 more source

Molecular Cloning and Expression of Human Regulators of G-Protein Signaling 4, 5, and 16

McGill Journal of Medicine, 2020
N ...
Aravind Athiviraham
doaj   +1 more source

Platelet calcium signaling by G-protein coupled and ITAM-linked receptors regulating anoctamin-6 and procoagulant activity

Platelets, 2021
Most agonists stimulate platelet Ca2+ rises via G-protein coupled receptors (GPCRs) or ITAM-linked receptors (ILRs). Well studied are the GPCRs stimulated by the soluble agonists thrombin (PAR1, PAR4), ADP (P2Y1, P2Y12), and thromboxane A2 (TP ...
Delia I. Fernández, Marijke J. E. Kuijpers, Johan W. M. Heemskerk   +2 more
doaj   +1 more source

pdCSM-GPCR: predicting potent GPCR ligands with graph-based signatures. [PDF]

, 2022
MOTIVATION: G protein-coupled receptors (GPCRs) can selectively bind to many types of ligands, ranging from light-sensitive compounds, ions, hormones, pheromones and neurotransmitters, modulating cell physiology.

core   +2 more sources