Results 21 to 30 of about 61,856 (262)
Vascular Biology, 2019 The discovery and extension of G-protein-coupled receptor (GPCR) transactivation-dependent signalling has enormously broadened the GPCR signalling paradigm.
Raafat Mohamed +9 more
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PRED-GPCR: GPCR recognition and family classification server [PDF]
Nucleic Acids Research, 2004 The vast cell-surface receptor family of G-protein coupled receptors (GPCRs) is the focus of both academic and pharmaceutical research due to their key role in cell physiology along with their amenability to drug intervention. As the data flow rate from the various genome and proteome projects continues to grow, so does the need for fast, automated and
Panagiotis K. Papasaikas +4 more
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CHIMIA, 2021 Nervous system disorders affect millions of people around the world, through a very broad range of diseases. Here we describe our contribution to find a treatment for patients suffering from three of those diseases.
Hasane Ratni
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Development of PCR based approach to detect potential mosaicism in porcine embryos
Journal of Animal Reproduction and Biotechnology, 2020 Direct injection of genome editing tools such as CRISPR/Cas9 system into developing embryos has been widely used to generate genetically engineered pigs.
Jongki Cho +5 more
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Ligands can differentially and temporally modulate GPCR interaction with 14-3-3 isoforms
Current Research in Pharmacology and Drug Discovery, 2022 GPCR signaling and function depend on their associated proteins and subcellular locations. Besides G-proteins and β-arrestins, 14-3-3 proteins participate in GPCR trafficking and signaling, and they connect a large number of diverse proteins to form ...
Haifeng Eishingdrelo +4 more
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Agonist and antagonist TRUPATH assays for G protein-coupled receptors
STAR Protocols, 2022 Summary: TRUPATH is a bioluminescence resonance energy transfer-based platform for quantifying G protein-coupled receptor activity via dissociation of heterotrimeric G protein biosensors.
Jeffrey F. DiBerto +3 more
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The Secretin GPCRs Descended from the Family of Adhesion GPCRs [PDF]
Molecular Biology and Evolution, 2008 The Adhesion G-protein-coupled receptors (GPCRs) are the most complex gene family among GPCRs with large genomic size, multiple introns, and a fascinating flora of functional domains, though the evolutionary origin of this family has been obscure. Here we studied the evolution of all class B (7tm2)-related genes, including the Adhesion, Secretin, and ...
Karl J V, Nordström +4 more
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Odorant receptors can mediate axonal identity and gene choice via cAMP-independent mechanisms [PDF]
Open Biology, 2016 Odorant receptors (ORs) control several aspects of cell fate in olfactory sensory neurons (OSNs), including singular gene choice and axonal identity.
Kiavash Movahedi +2 more
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Annals of HematologyInhibitors of C-X-C chemokine receptor type 4 (CXCR4) are standard of care for mobilization of hematopoietic stem and progenitor cells (HPC) in transplant eligible patients with hematological malignancies or undergoing HPC-based gene therapies. Burixafor
Devki D. Sukhtankar +8 more
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Genetically encoded fluorescent biosensors for GPCR research
Frontiers in Cell and Developmental Biology, 2022 G protein-coupled receptors (GPCRs) regulate a wide range of physiological and pathophysiological cellular processes, thus it is important to understand how GPCRs are activated and function in various cellular contexts.
Hyunbin Kim +6 more
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