Results 21 to 30 of about 83,092 (356)
Platelets, 2021 Most agonists stimulate platelet Ca2+ rises via G-protein coupled receptors (GPCRs) or ITAM-linked receptors (ILRs). Well studied are the GPCRs stimulated by the soluble agonists thrombin (PAR1, PAR4), ADP (P2Y1, P2Y12), and thromboxane A2 (TP ...
Delia I. Fernández +2 more
doaj +1 more source
On the hierarchical classification of G Protein-Coupled Receptors [PDF]
, 2007 Motivation: G protein-coupled receptors (GPCRs) play an important role in many physiological systems by transducing an extracellular signal into an intracellular response. Over 50% of all marketed drugs are targeted towards a GPCR.
Matthew N. Davies +11 more
core +1 more source
pdCSM-GPCR: predicting potent GPCR ligands with graph-based signatures [PDF]
, 2021 MOTIVATION: G protein-coupled receptors (GPCRs) can selectively bind to many types of ligands, ranging from light-sensitive compounds, ions, hormones, pheromones and neurotransmitters, modulating cell physiology.
Velloso, JPL, Ascher, DB, Pires, DEV
core +1 more source
A computational model for GPCR-ligand interaction prediction
Journal of Integrative Bioinformatics, 2020 G protein-coupled receptors (GPCRs) play an essential role in critical human activities, and they are considered targets for a wide range of drugs. Accordingly, based on these crucial roles, GPCRs are mainly considered and focused on pharmaceutical ...
Karimi Shiva +3 more
doaj +1 more source
A Web Server for GPCR-GPCR Interaction Pair Prediction
Frontiers in Endocrinology, 2022 The GGIP web server (https://protein.b.dendai.ac.jp/GGIP/) provides a web application for GPCR-GPCR interaction pair prediction by a support vector machine. The server accepts two sequences in the FASTA format. It responds with a prediction that the input GPCR sequence pair either interacts or not.
Wataru Nemoto +7 more
openaire +3 more sources
BiasNet: A model to predict ligand bias towards GPCR signaling
, 2021 Signaling bias is a feature of many G–protein coupled receptor (GPCR) modulating drugs with clinical implications. Whether it is therapeutically advantageous for a drug to be G Protein biased or β-Arrestin (β-Arr) biased, depends on the context of the ...
Govinda, KC +4 more
core +1 more source
A Benchmark for Accurate GPCR Ligand Binding Affinity Prediction with Free Energy Perturbation
, 2023 G protein-coupled receptors (GPCRs) are among the most important drug targets in the pharmaceutical industry. Free energy perturbation (FEP), which can accurately predict the relative binding free energies of drug molecules, is now widely used in drug ...
Yu, Zhou +9 more
core +1 more source
CHIMIA, 2021 Numerous members of the human G protein-coupled receptor (GPCR) superfamily are receptors of therapeutic interest. GPCRs are considered to be highly tractable for drug discovery, representing the targets of approximately one-third of currently licensed ...
Kalyan Bharati Akondi +2 more
doaj +1 more source
GPCR-induced YAP activation sensitizes fibroblasts to profibrotic activity of TGFβ1 - Table
, 2020 GPCR-induced YAP activation sensitizes fibroblasts to profibrotic activity of TGFβ1 ...
Magdalena Birker-Robaczewska (8447319) +11 more
core +1 more source
GPCRomics: An Approach to Discover GPCR Drug Targets [PDF]
, 2019 G protein-coupled receptors (GPCRs) are targets for ∼35% of approved drugs but only ∼15% of the ∼800 human GPCRs are currently such targets. GPCRomics, the use of unbiased, hypothesis-generating methods [e.g., RNA-sequencing (RNA-seq)], with tissues and ...
Insel, Paul A +20 more
core +1 more source