Results 21 to 30 of about 64,182 (259)

Nutrient sensing and cAMP signaling in yeast: G-protein coupled receptor versus transceptor activation of PKA

Microbial Cell, 2020
A major signal transduction pathway regulating cell growth and many associated physiological properties as a function of nutrient availability in the yeast Saccharomyces cerevisiae is the protein kinase A (PKA) pathway.
Griet Van Zeebroeck, Liesbeth Demuyser, Zhiqiang Zhang, Ines Cottignie, Johan M. Thevelein   +4 more
doaj   +1 more source

Molecular Cloning and Expression of Human Regulators of G-Protein Signaling 4, 5, and 16

McGill Journal of Medicine, 2020
N ...
Aravind Athiviraham
doaj   +1 more source

GPCR photopharmacology

Molecular and Cellular Endocrinology, 2019
New technologies for spatial and temporal remote control of G protein-coupled receptors (GPCRs) are necessary to unravel the complexity of GPCR signalling in cells, tissues and living organisms. An effective approach, recently developed, consists on the design of light-operated ligands whereby light-dependent GPCR activity regulation can be achieved ...
Maria Ricart-Ortega, Joan Font, Amadeu Llebaria   +2 more
openaire   +3 more sources

Platelet calcium signaling by G-protein coupled and ITAM-linked receptors regulating anoctamin-6 and procoagulant activity

Platelets, 2021
Most agonists stimulate platelet Ca2+ rises via G-protein coupled receptors (GPCRs) or ITAM-linked receptors (ILRs). Well studied are the GPCRs stimulated by the soluble agonists thrombin (PAR1, PAR4), ADP (P2Y1, P2Y12), and thromboxane A2 (TP ...
Delia I. Fernández, Marijke J. E. Kuijpers, Johan W. M. Heemskerk   +2 more
doaj   +1 more source

A Web Server for GPCR-GPCR Interaction Pair Prediction

Frontiers in Endocrinology, 2022
The GGIP web server (https://protein.b.dendai.ac.jp/GGIP/) provides a web application for GPCR-GPCR interaction pair prediction by a support vector machine. The server accepts two sequences in the FASTA format. It responds with a prediction that the input GPCR sequence pair either interacts or not.
Wataru Nemoto, Wataru Nemoto, Yoshihiro Yamanishi, Vachiranee Limviphuvadh, Shunsuke Fujishiro, Sakie Shimamura, Aoi Fukushima, Hiroyuki Toh   +7 more
openaire   +3 more sources

Precision-engineered Peptide and Protein Analogs: Establishing a New Discovery Platform for Potent GPCR Modulators

CHIMIA, 2021
Numerous members of the human G protein-coupled receptor (GPCR) superfamily are receptors of therapeutic interest. GPCRs are considered to be highly tractable for drug discovery, representing the targets of approximately one-third of currently licensed ...
Kalyan Bharati Akondi, Marianne Paolini-Bertrand, Oliver Hartley   +2 more
doaj   +1 more source

GPCRs

, 2021
This presentation is about ...
Donya Salehi, Seyed amin motohamelian, Mostafa Shir Mohammadi   +2 more
openaire   +2 more sources

Arrestin-3 differentially regulates platelet GPCR subsets

Platelets, 2020
The principal demonstrated role of the nonvisual arrestins in vivo is to limit G protein-coupled receptor (GPCR) signaling. Nonetheless, a direct demonstration of this fundamental ability in platelets remains lacking, despite the prominent role played by
James L. Hutchinson, Xiaojuan Zhao, Rob Hill, Stuart J. Mundell   +3 more
doaj   +1 more source

Below the Surface: IGF-1R Therapeutic Targeting and Its Endocytic Journey

Cells, 2019
Ligand-activated plasma membrane receptors follow pathways of endocytosis through the endosomal sorting apparatus. Receptors cluster in clathrin-coated pits that bud inwards and enter the cell as clathrin-coated vesicles.
Caitrin Crudden, Dawei Song, Sonia Cismas, Eric Trocmé, Sylvya Pasca, George A. Calin, Ada Girnita, Leonard Girnita   +7 more
doaj   +1 more source

Innovative Approach Reveals How Receptors Control G Protein State Equilibria [PDF]

Advanced science
Using conformational specific trFRET biosensors of the Gi protein (depicted at the bottom), the authors show that receptor activation can not only release GDP from the inactive G protein, but can also release GTP from the activated G protein, leading to the reformation of the RG ternary complex.
Bouyssou A, Da Silva M, Soulé J, Fabre L, Lamarque L, Sounier R, Durroux T, Granier S, Roux T, Dupuis E, Trinquet E, Rondard P, Pin J.   +12 more
europepmc   +2 more sources