Results 21 to 30 of about 2,928 (195)

Effects of Small Molecule Ligands on ACKR3 Receptors

Molecular Pharmacology, 2022
Chemokines such as stromal derived factor 1 and their G protein coupled receptors are well-known regulators of the development and functions of numerous tissues. C-X-C motif chemokine ligand 12 (CXCL12) has two receptors: C-X-C chemokine motif receptor 4
Miller, R.J., Malik, N., Miller, Richard J., Schiltz, Gary E., Ren, D., Iyamu, I.D., Hopkins, Brittany E., Lv, Wei, Masuho, Ikuo, Lv, W., Martemyanov, K.A., Malik, Neha, Martemyanov, Kirill A., Hopkins, B.E., Ren, Dongjun, Iyamu, Iredia D., Masuho, I., Schiltz, G.E.   +17 more
core   +3 more sources

Lymphatic Activation of ACKR3 Signaling Regulates Lymphatic Response After Ischemic Heart Injury. [PDF]

Arterioscler Thromb Vasc Biol
BACKGROUND: Ischemic heart disease is a prevalent cause of death and disability worldwide. Recent studies reported a rapid expansion of the cardiac lymphatic network upon ischemic heart injury and proposed that cardiac lymphatics may attenuate tissue ...
Balint L, Patel S, Serafin DS, Zhang H, Quinn KE, Aghajanian A, Kistner BM, Caron KM.   +7 more
europepmc   +3 more sources

Modulators of CXCR4 and CXCR7/ACKR3 Function [PDF]

Molecular Pharmacology, 2019
Copyright © 2019 by The Author(s). The two G protein-coupled receptors (GPCRs) C-X-C chemokine receptor type 4 (CXCR4) and atypical chemokine receptor 3 (ACKR3) are part of the class A chemokine GPCR family and represent important drug targets for human ...
Visser, Kirsten, Hill, Stephen, Kellam, Barrie, Leurs, Rob, Wijtmans, Maikel, Dekkers, Sebastian, Stocks, Michael, Briddon, Stephen, Stuijt, Jeffrey, Arimont, Marta, Adlere, Ilze, Caspar, Birgit, de Esch, Iwan; id_orcid, de Graaf, Chris, de Esch, Iwan   +14 more
core   +5 more sources

ACKR3 in Health and Disease:From Fundamental Insights To Drug Discovery [PDF]

Introduced in Chapter 1, Cxcl12 and Cxcr4 play crucial roles during development, adult life and pathophysiology, in particular in hematopoiesis, inflammatory disease and cancer progression.
Koenen, Joyce
core   +3 more sources

Differential Involvement of ACKR3 C-Tail in β-Arrestin Recruitment, Trafficking and Internalization

Cells, 2021
Background: The atypical chemokine receptor 3 (ACKR3) belongs to the superfamily of G protein-coupled receptors (GPCRs). Unlike classical GPCRs, this receptor does not activate G proteins in most cell types but recruits β-arrestins upon activation. ACKR3
Aurélien Zarca, Claudia Perez, Jelle van den Bor, Jan Paul Bebelman, Joyce Heuninck, Rianna J. F. de Jonker, Thierry Durroux, Henry F. Vischer, Marco Siderius, Martine J. Smit   +9 more
doaj   +2 more sources

Heterogeneous expression of the atypical chemokine receptor ACKR3 in glioblastoma patient-derived tissue samples and cell cultures

Scientific Reports
Glioblastoma (GBM) is the most aggressive glial tumor of the adult brain, associated with invariably fatal outcome, and a deeper understanding of the underlying malignant mechanisms is necessary to address the current therapeutic failure.
Damla Isci, Amandine Kuppens, Joshua Scalisi, Julie Cokaiko, Giulia D’Uonnolo, May Wantz, Martyna Szpakowska, Andy Chevigné, Bernard Rogister, Virginie Neirinckx   +9 more
doaj   +2 more sources

Circulating hsa_circ_0072309, acting via the miR‐100/ACKR3 pathway, maybe a potential biomarker for the diagnosis, prognosis, and treatment of brain metastasis from non‐small‐cell lung cancer

Cancer Medicine, 2023
Background One of the main causes of lung cancer‐related death is brain metastasis (BM). Finding early indicators of BM derived from lung cancer is crucial.
Xiao‐Qiang Zhang, Qian Song, Lin‐Xiang Zeng   +2 more
doaj   +2 more sources

The CXCL12/CXCR4/ACKR3 Signaling Axis Regulates PKM2 and Glycolysis

Cells, 2022
In response to CXCL12, CXCR4 and ACKR3 both recruit β-arrestin 2, regulating the assembly of interacting proteins that drive signaling and contribute to the functions of both receptors in cancer and multiple other diseases.
Kathryn E. Luker, Gary D. Luker
doaj   +3 more sources

MIF-ACKR3 causes irreversible fat loss by impairing adipogenesis in cancer cachexia

Cell Metabolism
Both exercise and cancer can cause adipose tissue shrinkage. However, only cancer-associated weight loss, namely cachexia, is characterized by profound adipose inflammation and fibrosis.
Qionghua Cui, Shijin Li, Xidan Liu, Jie Liu, Wenxin Chen, Ye Sheng, Peng Xie, Li Jin, Fanxin Zeng, Fengxiang Lv, Xinli Hu, Rui-Ping Xiao   +11 more
exaly   +2 more sources

Distinct activation mechanisms of CXCR4 and ACKR3 revealed by single-molecule analysis of their conformational landscapes [PDF]

eLife
The canonical chemokine receptor CXCR4 and atypical receptor ACKR3 both respond to CXCL12 but induce different effector responses to regulate cell migration.
Christopher T Schafer, Raymond F Pauszek III, Martin Gustavsson, Tracy M Handel, David P Millar   +4 more
doaj   +2 more sources