Single-cell RNA sequencing reveals the potential role of Postn(+) fibroblasts in promoting the progression of myocardial fibrosis after myocardial infarction [PDF]
Scientific ReportsMyocardial infarction (MI) is a life-threatening coronary artery-related pathology characterized by sudden cardiac death, often leading to cardiac fibrosis and heart failure (HF).
Wenyang Nie +6 more
doaj +2 more sources
Reassessing the adrenomedullin scavenging function of ACKR3 in lymphatic endothelial cells.
PLoS ONE, 2023 Atypical chemokine receptor 3 (ACKR3) is a scavenger of the chemokines CXCL11 and CXCL12 and of several opioid peptides. Additional evidence indicates that ACKR3 binds two other non-chemokine ligands, namely the peptide hormone adrenomedullin (AM) and ...
Elena C Sigmund +7 more
doaj +1 more source
Identification and functional characterization of arginine vasopressin receptor 1A : atypical chemokine receptor 3 heteromers in vascular smooth muscle [PDF]
Open Biology, 2018 Recent observations suggest that atypical chemokine receptor (ACKR)3 and chemokine (C-X-C motif) receptor (CXCR)4 regulate human vascular smooth muscle function through hetero-oligomerization with α1-adrenoceptors. Here, we show that ACKR3 also regulates
Lauren J. Albee +8 more
doaj +1 more source
Single-Cell Transcriptomics Reveals Dynamic Cellular Interactions and Molecular Mechanisms in Myocardial Infarction Recovery. [PDF]
Int J GenomicsBackground Repair and remodeling following myocardial infarction (MI) are complex processes with a wide array of cellular and molecular mechanisms; however, the cell source mediating repair is still poorly understood in terms of heterogeneity and temporal dynamics.
Zhao J, Gong J, Zhu C.
europepmc +2 more sources
PLoS ONE, 2021 Atypical chemokine receptor ACKR3 (formerly CXCR7) is a scavenging receptor that has recently been implicated in murine lymphatic development. Specifically, ACKR3-deficiency was shown to result in lymphatic hyperplasia and lymphedema, in addition to ...
Elena C Sigmund +8 more
doaj +1 more source
Adipocyte-Specific ACKR3 Regulates Lipid Levels in Adipose Tissue
Biomedicines, 2021 Dysfunctional adipose tissue (AT) may contribute to the pathology of several metabolic diseases through altered lipid metabolism, insulin resistance, and inflammation.
Selin Gencer +8 more
doaj +1 more source
Ackr3-Venus knock-in mouse lights up brain vasculature
Molecular Brain, 2021 The atypical chemokine receptor 3, ACKR3, is a G protein-coupled receptor, which does not couple to G proteins but recruits βarrestins. At present, ACKR3 is considered a target for cancer and cardiovascular disorders, but less is known about the ...
Aliza T. Ehrlich +11 more
doaj +1 more source
Atypical Roles of the Chemokine Receptor ACKR3/CXCR7 in Platelet Pathophysiology
Cells, 2022 The manifold actions of the pro-inflammatory and regenerative chemokine CXCL12/SDF-1α are executed through the canonical GProteinCoupledReceptor CXCR4, and the non-canonical ACKR3/CXCR7.
Madhumita Chatterjee
doaj +1 more source
Role and implications of the CXCL12/CXCR4/CXCR7 axis in atherosclerosis: still a debate
Annals of Medicine, 2021 Atherosclerosis is one of the leading causes of mortality and morbidity worldwide. Chemokines and their receptors are implicated in the pathogenesis of atherosclerosis.
Hussam A. S. Murad +2 more
doaj +1 more source
What doesn't kill you makes you stranger: Dipeptidyl peptidase-4 (CD26) proteolysis differentially modulates the activity of many peptide hormones and cytokines generating novel cryptic bioactive ligands [PDF]
, 2019 Dipeptidyl peptidase 4 (DPP4) is an exopeptidase found either on cell surfaces where it is highly regulated in terms of its expression and surface availability (CD26) or in a free/circulating soluble constitutively available and intrinsically active form.
Aguilar-Pérez, Alexandra +13 more
core +1 more source