ACKR3 Regulation of Neuronal Migration Requires ACKR3 Phosphorylation, but Not β-Arrestin [PDF]
Cell Reports, 2019 Summary: Phosphorylation of heptahelical receptors is thought to regulate G protein signaling, receptor endocytosis, and non-canonical signaling via recruitment of β-arrestins.
Stefan Schulz +2 more
exaly +6 more sources
ACKR3 regulates platelet activation and ischemia-reperfusion tissue injury [PDF]
Nature Communications, 2022 ACKR3 is a critical regulator of platelet-mediated thrombosis and organ injury following ischemia/reperfusion. Platelet ACKR3 surface expression is independently associated with all-cause mortality in patients with cardiovascular diseases.
Anne-Katrin Rohlfing +42 more
doaj +6 more sources
Atypical Roles of the Chemokine Receptor ACKR3/CXCR7 in Platelet Pathophysiology [PDF]
Cells, 2022 The manifold actions of the pro-inflammatory and regenerative chemokine CXCL12/SDF-1α are executed through the canonical GProteinCoupledReceptor CXCR4, and the non-canonical ACKR3/CXCR7.
Madhumita Chatterjee
exaly +7 more sources
ACKR3 promotes CXCL12/CXCR4-mediated cell-to-cell-induced lymphoma migration through LTB4 production [PDF]
Frontiers in Immunology, 2023 Chemotaxis is an essential physiological process, often harnessed by tumors for metastasis. CXCR4, its ligand CXCL12 and the atypical receptor ACKR3 are overexpressed in many human cancers.
Paola Antonello +10 more
doaj +4 more sources
Ackr3-Venus knock-in mouse lights up brain vasculature [PDF]
Molecular Brain, 2021 The atypical chemokine receptor 3, ACKR3, is a G protein-coupled receptor, which does not couple to G proteins but recruits βarrestins. At present, ACKR3 is considered a target for cancer and cardiovascular disorders, but less is known about the ...
Aliza T. Ehrlich +11 more
doaj +7 more sources
Emerging Roles of the Atypical Chemokine Receptor 3 (ACKR3) in Cardiovascular Diseases
Frontiers in Endocrinology, 2022 Chemokines, and their receptors play a crucial role in the pathophysiology of cardiovascular diseases (CVD). Chemokines classically mediate their effects by binding to G-protein-coupled receptors.
Angelique Levoye +1 more
exaly +5 more sources
ELUCIDATE ACKR3 EXPRESSION AND FUNCTION IN GLIOBLASTOMA-ASSOCIATED MICROENVIRONMENT [PDF]
Neuro OncolGlioblastoma is the most prevalent primary brain tumor in adults, leading to a grim prognosis. The development of efficient therapies is limited by several factors, including the immunosuppressive tumor microenvironment.
Amandine Kuppens +5 more
europepmc +3 more sources
Small Molecule Fluorescent Ligands for the Atypical Chemokine Receptor 3 (ACKR3) [PDF]
ACS Medicinal Chemistry Letters, 2023 The atypical chemokine receptor 3 (ACKR3) is a receptor that induces cancer progression and metastasis in multiple cell types. Therefore, new chemical tools are required to study the role of ACKR3 in cancer and other diseases.
S. Dekkers +12 more
semanticscholar +5 more sources
The Role of the CXCL12/CXCR4/ACKR3 Axis in Autoimmune Diseases [PDF]
Frontiers in Endocrinology, 2019 Chemokine receptors are members of the G protein-coupled receptor superfamily. These receptors are intimately involved in cell movement, and thus play a critical role in several physiological and pathological situations that require the precise ...
Yasmina Juarranz +2 more
exaly +7 more sources
ACKR3 upregulation under hyperglycemia associates with endothelial dysfunction
Advanced Pharmaceutical BulletinPurpose: Diabetes is a metabolic disorder characterized by chronic hyperglycemia and is associated with cardiovascular complications. Endothelial cell dysfunction is a common feature of both diabetes and its vascular complications. In this study, RNA-seq
Seyedeh Zohreh Azarshin +5 more
semanticscholar +3 more sources