Results 41 to 50 of about 2,928 (195)
The Role of ACKR3 in Breast, Lung, and Brain Cancer [PDF]
Molecular Pharmacology, 2019 Recent reports regarding the significance of chemokine receptors in disease have put a spotlight on atypical chemokine receptor 3 (ACKR3). This atypical chemokine receptor is overexpressed in numerous cancer types and has been involved in the modulation of tumor cell proliferation and migration, tumor angiogenesis, or resistance to drugs, thus ...
Neves, Maria +5 more
openaire +6 more sources
Identification and functional characterization of arginine vasopressin receptor 1A : atypical chemokine receptor 3 heteromers in vascular smooth muscle [PDF]
Open Biology, 2018 Recent observations suggest that atypical chemokine receptor (ACKR)3 and chemokine (C-X-C motif) receptor (CXCR)4 regulate human vascular smooth muscle function through hetero-oligomerization with α1-adrenoceptors. Here, we show that ACKR3 also regulates
Lauren J. Albee +8 more
doaj +1 more source
PLoS ONE, 2021 Atypical chemokine receptor ACKR3 (formerly CXCR7) is a scavenging receptor that has recently been implicated in murine lymphatic development. Specifically, ACKR3-deficiency was shown to result in lymphatic hyperplasia and lymphedema, in addition to ...
Elena C Sigmund +8 more
doaj +1 more source
Antibodies Targeting Chemokine Receptors CXCR4 and ACKR3 [PDF]
Molecular Pharmacology, 2019 Dysregulation of the chemokine system is implicated in a number of autoimmune and inflammatory diseases, as well as cancer. Modulation of chemokine receptor function is a very promising approach for therapeutic intervention. Despite interest from academic groups and pharmaceutical companies, there are currently few approved medicines targeting ...
Bobkov, Vladimir +6 more
openaire +4 more sources
Synthesis and radiolabelling of ackr3 binding peptides as positron emission tomography imaging probes [PDF]
, 2021 Atypical chemokine receptor 3 (ACKR3) is an atypical chemokine receptor involved in a variety of physiological processes, including cardiac development and vascular function.
Cetin, Aynil
core +6 more sources
Role and implications of the CXCL12/CXCR4/CXCR7 axis in atherosclerosis: still a debate
Annals of Medicine, 2021 Atherosclerosis is one of the leading causes of mortality and morbidity worldwide. Chemokines and their receptors are implicated in the pathogenesis of atherosclerosis.
Hussam A. S. Murad +2 more
doaj +1 more source
EBioMedicine, 2021 Background: Emphysematous COPD is characterized by aberrant alveolar repair. Macrophage migration inhibitory factor (MIF) contributes to alveolar repair, but for its structural and functional homolog D-dopachrome tautomerase (DDT) this is unknown.
Shanshan Song +11 more
doaj +1 more source
CENPF Promotes EMT in Non-small Cell Lung Cancer by Up-regulating ACKR3/CXCR7
Zhongliu Fangzhi Yanjiu, 2022 Objective To investigate the relationship between the expression of CENPF in NSCLC adenocarcinoma (LUAD) and the clinical prognosis of patients and its effect on the metastasis of lung adenocarcinoma cells. Methods The expression of CENPF in LUAD and its
GU Tong +6 more
doaj +1 more source
From Insight to Modulation of CXCR4 and ACKR3 (CXCR7) Function [PDF]
Molecular Pharmacology, 2019 Chemokine receptors CXCR4 and atypical chemokine receptor 3 (ACKR3/CXCR7) are highly expressed in a range of tumors. Yet, their role in cancer progression is not well understood. This minireview series encompasses seven comprehensive reviews focusing on modulators (small molecules, pepducins, antibodies), structural aspects, spatio-temporal signaling ...
Smit, Martine J. +1 more
openaire +3 more sources
Ligand-regulated ACKR3 nanoclustering shapes CXCR4 signaling at the plasma membrane
Recent advances in imaging have revealed that chemokine receptors integrate extracellular cues via dynamic nanoscale organization at the plasma membrane.
Santander-Acerete N +14 more
europepmc +2 more sources