Results 61 to 70 of about 2,928 (195)

Novel insights into neuroinflammation: bacterial lipopolysaccharide, tumor necrosis factor α, and Ureaplasma species differentially modulate atypical chemokine receptor 3 responses in human brain microvascular endothelial cells

Journal of Neuroinflammation, 2018
Background Atypical chemokine receptor 3 (ACKR3, synonym CXCR7) is increasingly considered relevant in neuroinflammatory conditions, in which its upregulation contributes to compromised endothelial barrier function and may ultimately allow inflammatory ...
Christine Silwedel, Christian P. Speer, Axel Haarmann, Markus Fehrholz, Heike Claus, Mathias Buttmann, Kirsten Glaser   +6 more
doaj   +1 more source

Role of Cx43 and ACKR3 in Modulating Astrocytic Response and Neuronal Survival Post‐Subarachnoid Hemorrhage

Glia
Subarachnoid hemorrhage (SAH) is a devastating neurological disorder that results from the accumulation of blood in the brain's subarachnoid space, leading to significant challenges in neurological recovery. This study explores the molecular interactions
Jian Yan, Shenhao Xie, Dianda Chen, Jinlin Xiao, Erming Zeng, Tao Hong, Jian Duan   +6 more
semanticscholar   +1 more source

Targeted Lysosomal Degradation of Extracellular and Membrane Proteins: From Receptor Hijacking to Programmable Endolysosomal Routing

Advanced Science, EarlyView.
Targeted chimeric degraders engage extracellular or membrane proteins and endocytosable cell‐surface receptors, forming ternary complexes that induce receptor‐mediated internalization. Following endocytosis, post‐endocytic sorting—not internalization alone—determines target fate.
Ke Liu, Xiyan Wang, Xiaozhen Liu, Chaoqi He, Da Qian, Xuli Meng, Liquan Zhu   +6 more
wiley   +1 more source

Plasticity of seven-transmembrane-helix receptor heteromers in human vascular smooth muscle cells.

PLoS ONE, 2021
Recently, we reported that the chemokine (C-X-C motif) receptor 4 (CXCR4) and atypical chemokine receptor 3 (ACKR3) heteromerize with α1A/B/D-adrenoceptors (ARs) and arginine vasopressin receptor 1A (AVPR1A) in recombinant systems and in rodent and human
Lauren J Albee, Xianlong Gao, Matthias Majetschak   +2 more
doaj   +1 more source

Down regulation of estrogen receptors (ER a ; ER β ) and atypical chemokine receptors (ACKR 2; ACKR3; ACKR4) to increase 17β-estradiol (E2) levels in MCF-7 in-vitro study

Basic & Clinical Cancer Research
Background: Oestrogen plays a vital role in breast development and is strongly re- lated to breast cancer. This research article delves into this paradox.
Shruti Talashi
semanticscholar   +1 more source

The Endothelial CXCR Family in Vascular Health and Disease

iNew Medicine, EarlyView.
ABSTRACT Endothelial cells (ECs) form the dynamic interface between blood and tissue, serving as key regulators of vascular homeostasis, inflammation, and repair. Among the molecular systems governing endothelial behavior, the C‐X‐C motif chemokine receptor (CXCR) family—originally characterized in immunology for its roles in leukocyte trafficking and ...
Zhiming Wu, Yandi Wu, Suowen Xu, Yu Huang, Li Wang   +4 more
wiley   +1 more source

Novel Small-Molecule Atypical Chemokine Receptor 3 (ACKR3) Agonists: Design, Synthesis, and Pharmacological Evaluation for Antiplatelet Therapy [PDF]

Cardiovascular diseases are one of the leading causes of mortality worldwide. Therefore, novel therapeutic measures are urgently needed, and promising new drug targets must be explored.
Manuel , Counson, Martyna, Szpakowska, Stefan, A. Laufer, Meinrad , Gawaz, Valerie , Dicenta-Baunach, Anne-Katrin , Rohlfing, Andy , Chevigné, Thanigaimalai, Pillaiyar, Alp, Bayrak, Alexander, Rasch   +9 more
core   +2 more sources

Multisystem multitasking by CXCL12 and its receptors CXCR4 and ACKR3

Cytokine, 2018
Chemokines are named and best known for their chemotactic cytokine activity in the hematopoietic system; however, their importance extends far beyond leukocytes, cell movement and immunoregulation. CXCL12, the most protean of chemokines, regulates development in multiple systems, including the hematopoietic, cardiovascular and nervous systems, and ...
Philip M, Murphy, Lauren, Heusinkveld
openaire   +3 more sources

The role of macrophage migration inhibitory factor (MIF) in the pathogenesis and progression of cardiovascular disease

British Journal of Pharmacology, Volume 183, Issue 19, Page 5732-5751, October 2026.
Abstract Cardiovascular disease (CVD) remains the leading global cause of death, driven by complex mechanisms, in which chronic inflammation plays a central role. Inflammatory pathways contribute to all stages of CVD, from endothelial dysfunction and plaque formation to erosion, rupture and myocardial injury.
Shreya Mahabhashyam, James Harris, Jürgen Bernhagen, Antony Vinh, Katrina M. Mirabito Colafella   +4 more
wiley   +1 more source

GPR182 and ACKR3 expression in the spleen.

, 2023
(A) Confocal images showing GPR182 (mCherry, red) colocalization with CD31+ vessels (green) in a cleared spleen (ACT-ECT) (scale bar = 20 μm). (B) Flow cytometry analysis on sorted GPR182-positive spleen endothelial cells stained for ICAM2, Meca32, and ...
Antal Rot (253362), Pawel Pelczar (137448), Marcus Thelen (164322), Serena Melgrati (14393832), Egle Radice (3340011), Sylvia Thelen (164318), Elin Hub (10110082), Rafet Ameti (15440688), David Jarrossay (254447)   +8 more
core   +1 more source