Results 81 to 90 of about 2,928 (195)

ACKR3 Antagonism Enhances the Repair of Demyelinated Lesions Through Both Immunomodulatory and Remyelinating Effects

Neurochemical Research
Addressing inflammation, demyelination, and associated neurodegeneration in inflammatory demyelinating diseases like multiple sclerosis (MS) remains challenging.
Laetitia Pouzol, A. Sassi, Mélanie Tunis, Anaïs Zurbach, Nadège Baumlin, Carmela Gnerre, Daniel S. Strasser, Julia Marrie, Enrico Vezzali, Marianne M. Martinic   +9 more
semanticscholar   +1 more source

Senolytic Treatment With Fisetin Reverses Age‐Related Endothelial Dysfunction Partially Mediated by SASP Factor CXCL12

Aging Cell, Volume 25, Issue 5, May 2026.
Single‐cell transcriptomics identifies that oral, intermittent fisetin supplementation improves endothelial function by targeting senescent endothelial cell‐derived senescence‐associated secretory phenotype (SASP) factors and CXCL12 in old animals. The SASP and specifically CXCL12 were found to drive age‐related endothelial dysfunction by promoting ...
Sophia A. Mahoney, Krystyna Mazan‐Mamczarz, Dimitrios Tsitsipatis, Nicholas S. VanDongen, Charnae’ Henry‐Smith, Ada N. Okereke, Rachel Munk, Sanna Darvish, Kevin O. Murray, Supriyo De, Myriam Gorospe, Douglas R. Seals, Matthew J. Rossman, Allison B. Herman, Zachary S. Clayton   +14 more
wiley   +1 more source

Peptide‐Incorporated Biomaterials Promote Regeneration of Peripheral Nerve Injuries

Advanced Science, Volume 13, Issue 23, 23 April 2026.
Peptide‐incorporated biomaterials provide precise, tunable biological cues that mimic functional protein domains to regulate behaviors of neurons, Schwann cells, immune cells, and endothelial cells, thereby enhancing axon elongation, Schwann cell support, inflammatory microenvironment modulation, and vascularization, offering a promising alternative to
Zhiwei Zhao, Jianfeng Liu, Jincheng Li, Di Li, Jianxun Ding, Bin Liu   +5 more
wiley   +1 more source

L'étude du récepteur ACKR3/CXCR7 dans le glioblastome

, 2022
peer reviewedAfter validation of ACKR3 staining by using U87-ACKR3 cell line, we showed that ACKR3 expression was very low in patients GBM stem-like cells. However we detect the receptor on GBM patient tissue, where it appears distributed in various cell
Isci, Damla, Neirinckx, Virginie, Veiga, Da, Chevigné, Andy, Cokaiko, Julie, LOMBARD, Arnaud, ROGISTER, Bernard   +6 more
core  

The role of ACKR3 in Cell Physiology and Pathology

, 2023
© 2024 Fatemeh KhatamiChemokine receptors have a central role in orchestrating cell and cell-niche interaction. This interaction is crucial in maintaining immune homeostasis and organogenesis.
Khatami, Fatemeh
core   +1 more source

From Heterogeneity to Plasticity: Endothelial Dynamics in Lung Disease

Pulmonary Circulation, Volume 16, Issue 2, April 2026.
ABSTRACT Endothelial heterogeneity and plasticity play an important role in lung development, homeostasis, and pathology. In recent years, increasing evidence has demonstrated that endothelial dysfunction contributes to the progression of various lung diseases, such as ADRS, PF, PH, and lung developmental disorders.
Van Dung Nguyen, Bisheng Zhou
wiley   +1 more source

Dual Targeting of the Chemokine Receptors CXCR4 and ACKR3 with Novel Engineered Chemokines [PDF]

Journal of Biological Chemistry, 2015
The chemokine CXCL12 and its G protein-coupled receptors CXCR4 and ACKR3 are implicated in cancer and inflammatory and autoimmune disorders and are targets of numerous antagonist discovery efforts. Here, we describe a series of novel, high affinity CXCL12-based modulators of CXCR4 and ACKR3 generated by selection of N-terminal CXCL12 phage libraries on
Hanes, M., Salanga, C., Chowdry, A., Comerford, I., McColl, S., Kufareva, I., Handel, T.   +6 more
openaire   +4 more sources

Atlas of the anatomical localization of atypical chemokine receptors in healthy mice.

PLoS Biology, 2023
Atypical chemokine receptors (ACKRs) scavenge chemokines and can contribute to gradient formation by binding, internalizing, and delivering chemokines for lysosomal degradation.
Serena Melgrati, Egle Radice, Rafet Ameti, Elin Hub, Sylvia Thelen, Pawel Pelczar, David Jarrossay, Antal Rot, Marcus Thelen   +8 more
doaj   +1 more source

ACKR3 agonism induces heterodimerization with chemokine receptor CXCR4 and attenuates platelet function

bioRxiv
Background Platelet receptors ACKR3 and CXCR4 play a crucial role in a variety of cardio-vascular diseases. Like most chemokine receptors, CXCR4 is a G protein coupled receptor that induces platelet activation.
Valerie Dicenta-Baunach, Zoi Laspa, David Schaale, Manuel Sigle, Alpaykut Bayrak, T. Castor, Thanigaimalai Pillaiyar, Stefan Laufer, M. Gawaz, A. Rohlfing   +9 more
semanticscholar   +1 more source

Traditional Chinese Medicine as an Integrative Adjunct in Oncology Perioperative Practice: Analgesia, Immune Modulation, and Translational Challenges

Medicine Bulletin, Volume 2, Issue 2, Page 184-204, March 2026.
ABSTRACT Traditional Chinese medicine (TCM), including herbal analgesic adjuvants and acupuncture‐based interventions, has gained increasing attention as an integrative strategy for perioperative pain management in oncology. Bioactive phytochemicals—such as terpenoids, flavonoids, alkaloids, and polyphenols—exert multimodal pharmacological effects ...
Yuqin Tang, Zheng Luo, Xu Zhao, Yongqiang Zhang, Mingyang Sun, Jiaqiang Zhang   +5 more
wiley   +1 more source