Results 81 to 90 of about 3,160 (160)
RAMP3 determines rapid recycling of atypical chemokine receptor-3 for guided angiogenesis. [PDF]
, 2019 Receptor-activity-modifying proteins (RAMPs) are single transmembrane-spanning proteins which serve as molecular chaperones and allosteric modulators of G-protein-coupled receptors (GPCRs) and their signaling pathways. Although RAMPs have been previously
Caron, Kathleen M +7 more
core +2 more sources
Receptor‐Dependent and ‐Independent Effects of Hemin on Platelet Plasma Membrane Disintegration
The FASEB Journal, Volume 40, Issue 2, 31 January 2026.Microhemorrhages lead to the release of erythrocytes, which are then degraded and lysed. These hemolyses result in the liberation of free iron‐containing hemin. Hemin induces platelet activation and ferroptosis. Inhibition of GPVI/CLEC‐2 receptor‐mediated ITAM‐signaling inhibits hemin‐induced platelet activation (low hemin concentrations). Deferoxamine,
Zoi Laspa +5 more
wiley +1 more source
Journal of Cellular and Molecular Medicine, Volume 30, Issue 2, January 2026.ABSTRACT Cervical cancer has become a glaring concern for women's health globally. The use of single‐cell RNA sequencing (scRNA‐seq) contributes to a comprehensive understanding of cellular heterogeneity and the immune cell landscape in the TME of cervical cancer.
Changchang Huang +4 more
wiley +1 more source
Advanced Science, Volume 12, Issue 48, December 29, 2025.Neoadjuvant gemcitabine plus nab‐paclitaxel (AG) reprograms pancreatic ductal adenocarcinoma by shifting malignant cells toward a classical phenotype and remodeling the tumor microenvironment. Despite enhancing cytotoxic NKT cells, AG activates tumor‐associated mast cells (TAMCs) and inflammatory CAFs through MIF signaling.
Libo Wang +16 more
wiley +1 more source
Translational Oncology, 2015 Inflammatory breast cancer (IBC) is an aggressive and invasive tumor, accounting for 2.5% of all breast cancer cases, and characterized by rapid progression, regional and distant metastases, younger age of onset, and lower overall survival.
Roberto Wurth +6 more
doaj +1 more source
Modulation of non-canonical CXCR4 and ACKR3 functions [PDF]
The large family of G protein-coupled receptor (GPCR) family transduce extracellular signals via diverse signaling pathways to control physiological functions.
Perez Almeria, Claudia Victoria
core +1 more source
In vitro pharmacological characterisation of the role of ACKR3 on CXCR4-dependent and -independent function [PDF]
, 2020 CXC-motif chemokine Receptor 4 (CXCR4) and Atypical ChemoKine Receptor 3 (ACKR3) are two 7-transmembrane domain receptors often studied together due to their common ligand CXC-motif chemokine Ligand 12 (CXCL12) and the implication of said ligand in ...
Capoferri, Davide
core
2,3,7,8-Tetrachlorodibenzo-p-dioxin-induced RNA abundance changes identify Ackr3, Col18a1, Cyb5a and Glud1 as candidate mediators of toxicity [PDF]
, 2016 PMID: 27136898Peer ...
Boutros, Paul C +5 more
core +1 more source
Development of a circulating tumour cell culture model from head and neck squamous cell carcinoma
VIEW, Volume 6, Issue 6, December 2025.Nectin‐4 is frequently overexpressed in various solid tumors; however, conventional photosensitizers for photodynamic therapy (PDT) often exhibit poor aqueous solubility and nonspecific accumulation in healthy tissues, leading to off‐target phototoxicity. To overcome these limitations, we developed a Nectin‐4‐targeted nanobody‐chlorin e6 conjugate (NPC)
Xiaomin Huang +14 more
wiley +1 more source
The Role of the CXCL12/CXCR4/ACKR3 Axis in Autoimmune Diseases
Frontiers in Endocrinology, 2019 Chemokine receptors are members of the G protein-coupled receptor superfamily. These receptors are intimately involved in cell movement, and thus play a critical role in several physiological and pathological situations that require the precise ...
Eva M. García-Cuesta +5 more
doaj +1 more source