Results 101 to 110 of about 3,160 (160)

Peroxynitrite Exposure of CXCL12 Impairs Monocyte, Lymphocyte and Endothelial Cell Chemotaxis, Lymphocyte Extravasation in vivo and Anti-HIV-1 Activity

Frontiers in Immunology, 2018
CXCL12 is a chemotactic cytokine that attracts many different cell types for homeostasis and during inflammation. Under stress conditions, macrophages and granulocytes produce factors such as peroxynitrite as a consequence of their oxidative response ...
Rik Janssens, Rik Janssens, Daiane Boff, Daiane Boff, Pieter Ruytinx, Anneleen Mortier, Vincent Vanheule, Olav Larsen, Olav Larsen, Viktorija Daugvilaite, Mette M. Rosenkilde, Sam Noppen, Sandra Liekens, Dominique Schols, Ingrid De Meester, Ghislain Opdenakker, Sofie Struyf, Mauro M. Teixeira, Flávio A. Amaral, Paul Proost   +19 more
doaj   +1 more source

Quantification of increased biologically active CXCL12α plasma concentrations after ACKR3 antagonist treatment in humans

Clinical and Translational Science
CXCL12 acts as a chemoattractant by binding to the receptor CXCR4. The (atypical) chemokine receptor ACKR3 (CXCR7) scavenges CXCL12. Antagonism of ACKR3 thus leads to an increase in CXCL12 concentrations that has been used as a pharmacodynamic biomarker ...
Peter Blattmann, Hervé Farine, Brian Dan, Nicole Stiffler, Thomas Lefebvre, Christine Huynh, Patricia N. Sidharta, Jasper Dingemanse, Richard W. D. Welford, Marcel Keller, Daniel S. Strasser   +10 more
doaj   +1 more source

Changes in epithelial proportions and transcriptional state underlie major premenopausal breast cancer risks [PDF]

, 2018
The human breast undergoes lifelong remodeling in response to estrogen and progesterone, but hormone exposure also increases breast cancer risk. Here, we use single-cell analysis to identify distinct mechanisms through which breast composition and cell ...
Borowsky, Alexander D., Caruso, Joseph A., Desai, Tejal A., Gartner, Zev J., Gascard, Philippe, McGinnis, Christopher S., Murrow, Lyndsay M., Phong, Kiet, Thomson, Matthew, Tlsty, Thea, Weber, Robert J.   +10 more
core   +1 more source

Roxadustat Attenuates Adverse Remodeling Following Myocardial Infarction in Mice

Cells
Activation of the CXCL12/CXCR4/ACKR3 axis is known to aid myocardial repair through ischemia-triggered hypoxia-inducible factor-1α (HIF-1α). To enhance the upregulation of HIF-1α, we administered roxadustat, a novel prolyl hydroxylase inhibitor (PHI ...
Marc-Michael Zaruba, Simon Staggl, Santhosh Kumar Ghadge, Thomas Maurer, Jasmina Gavranovic-Novakovic, Vivek Jeyakumar, Patric Schönherr, Andreas Wimmer, Gerhard Pölzl, Axel Bauer, Moritz Messner   +10 more
doaj   +1 more source

Identification of whole blood mRNA and microRNA biomarkers of tissue damage and immune function resulting from amphetamine exposure or heat stroke in adult male rats.

PLoS ONE, 2019
This work extends the understanding of how toxic exposures to amphetamine (AMPH) adversely affect the immune system and lead to tissue damage. Importantly, it determines which effects of AMPH are and are not due to pronounced hyperthermia.
Luísa Camacho, Camila S Silva, Joseph P Hanig, Robert P Schleimer, Nysia I George, John F Bowyer   +5 more
doaj   +1 more source

Targeting the Atypical Chemokine Receptor ACKR3/CXCR7 for the treatment of cancer and other diseases [PDF]

, 2015
One of the greatest challenges in fighting cancer is cell targeting and biomarker selection. The Atypical Chemokine Receptor ACKR3/CXCR7 is expressed on many cancer cell types, including breast cancer and glioblastoma, and binds the endogenous ligands ...
NC DOCKS at The University of North Carolina at Greensboro, Vestal, Richard D.   +1 more
core  

The Role of C-X-C motif chemokine 12 in the crosstalk of brown adipocytes and microvascular endothelial cells [PDF]

The pandemic of obesity keeps on rising. Especially from a pharmacological point of view, treatment options are quite limited. Late research has shown that brown adipose tissue might be a promising target for the development of innovative therapeutic ...
Retiet, Max
core  

Bioinformatic Analysis and in Vitro Experimental Verification of the Intervention Effect of Shipi-Xiaoji Recipe on the Progression of non-Alcoholic Fatty Liver Disease to Liver Cancer

Natural Product Communications
Objective This study aimed to screen and identify central genes associated with the progression of non-alcoholic fatty liver disease (NAFLD) to hepatocellular carcinoma (HCC), to establish prognostic and clinical prediction models based on the expression
Jingting Zhang, Hongyao Chen, Kexiong Li, Wei Peng, Renyi Yang, Puhua Zeng   +5 more
doaj   +1 more source

Subarachnoid hemorrhage alters CX43 and ACKR3 levels in cerebrospinal fluid: A preclinical study

Asian Journal of Surgery, 2023
Jian Yan, Dianda Chen, Jian Duan, Tao Hong   +3 more
doaj   +1 more source

Specific GPCRs elicit unique extracellular vesicle miRNA array signatures. [PDF]

Elife
Shi X, Palumbo MC, Benware S, Wiedrick J, Markwardt S, Janowsky AJ.   +5 more
europepmc   +1 more source